ID   PITH1_XENLA             Reviewed;         209 AA.
AC   Q6DJI5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=PITH domain-containing protein 1;
GN   Name=pithd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in promoting megakaryocyte differentiation by
CC       up-regulating RUNX1 expression. {ECO:0000250|UniProtKB:Q9GZP4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9GZP4}.
CC   -!- SIMILARITY: Belongs to the PITHD1 family. {ECO:0000305}.
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DR   EMBL; BC075194; AAH75194.1; -; mRNA.
DR   RefSeq; NP_001086378.1; NM_001092909.1.
DR   AlphaFoldDB; Q6DJI5; -.
DR   SMR; Q6DJI5; -.
DR   BioGRID; 102970; 1.
DR   PRIDE; Q6DJI5; -.
DR   GeneID; 444807; -.
DR   KEGG; xla:444807; -.
DR   CTD; 444807; -.
DR   Xenbase; XB-GENE-1000971; pithd1.L.
DR   OMA; YHGVTIC; -.
DR   OrthoDB; 1561790at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 444807; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 2.60.120.470; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR045099; PITH1-like.
DR   InterPro; IPR010400; PITH_dom.
DR   InterPro; IPR037047; PITH_dom_sf.
DR   PANTHER; PTHR12175; PTHR12175; 1.
DR   Pfam; PF06201; PITH; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   PROSITE; PS51532; PITH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..209
FT                   /note="PITH domain-containing protein 1"
FT                   /id="PRO_0000285035"
FT   DOMAIN          18..190
FT                   /note="PITH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00864"
SQ   SEQUENCE   209 AA;  23557 MW;  B52BF04AB345B3B9 CRC64;
     MSHGHSHGGG CSCESEPSDG PERGLEYGLF RKIDLDKLQC LNESREGSGR SVFRAWEERN
     DRTRFVESDD DEELLFNIPF TGNVKLKGIV LIGEDSDTHP AELRLFKNVP HMSFDDTGRE
     ADQTFSLNID VNGNLEYPTK IARFSNVSHL SIHISKNFGA ENTKIYYIGL RGEWTEAHRH
     EVTICNYEAA ANPADHKVSQ ITPQTNFIS