PITH1_XENLA
ID PITH1_XENLA Reviewed; 209 AA.
AC Q6DJI5;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=PITH domain-containing protein 1;
GN Name=pithd1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in promoting megakaryocyte differentiation by
CC up-regulating RUNX1 expression. {ECO:0000250|UniProtKB:Q9GZP4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9GZP4}.
CC -!- SIMILARITY: Belongs to the PITHD1 family. {ECO:0000305}.
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DR EMBL; BC075194; AAH75194.1; -; mRNA.
DR RefSeq; NP_001086378.1; NM_001092909.1.
DR AlphaFoldDB; Q6DJI5; -.
DR SMR; Q6DJI5; -.
DR BioGRID; 102970; 1.
DR PRIDE; Q6DJI5; -.
DR GeneID; 444807; -.
DR KEGG; xla:444807; -.
DR CTD; 444807; -.
DR Xenbase; XB-GENE-1000971; pithd1.L.
DR OMA; YHGVTIC; -.
DR OrthoDB; 1561790at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 444807; Expressed in internal ear and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 2.60.120.470; -; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR045099; PITH1-like.
DR InterPro; IPR010400; PITH_dom.
DR InterPro; IPR037047; PITH_dom_sf.
DR PANTHER; PTHR12175; PTHR12175; 1.
DR Pfam; PF06201; PITH; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51532; PITH; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..209
FT /note="PITH domain-containing protein 1"
FT /id="PRO_0000285035"
FT DOMAIN 18..190
FT /note="PITH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00864"
SQ SEQUENCE 209 AA; 23557 MW; B52BF04AB345B3B9 CRC64;
MSHGHSHGGG CSCESEPSDG PERGLEYGLF RKIDLDKLQC LNESREGSGR SVFRAWEERN
DRTRFVESDD DEELLFNIPF TGNVKLKGIV LIGEDSDTHP AELRLFKNVP HMSFDDTGRE
ADQTFSLNID VNGNLEYPTK IARFSNVSHL SIHISKNFGA ENTKIYYIGL RGEWTEAHRH
EVTICNYEAA ANPADHKVSQ ITPQTNFIS