ID   PITP1_DICDI             Reviewed;         264 AA.
AC   Q9NCL8; Q54GK7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Phosphatidylinositol transfer protein 1;
DE            Short=PtdIns transfer protein 1;
DE   AltName: Full=DdPITP1;
GN   Name=pitA; ORFNames=DDB_G0290069;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], ACTIVITY AS PHOSPHATIDYLINOSITOL TRANSFER
RP   PROTEIN, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=AX3;
RX   PubMed=10769190; DOI=10.1042/bj3470837;
RA   Swigart P., Insall R., Wilkins A., Cockcroft S.;
RT   "Purification and cloning of phosphatidylinositol transfer proteins from
RT   Dictyostelium discoideum: homologues of both mammalian PITPs and
RT   Saccharomyces cerevisiae sec14p are found in the same cell.";
RL   Biochem. J. 347:837-843(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   PHOSPHORYLATION.
RC   STRAIN=AX2;
RX   PubMed=15352238; DOI=10.1002/pmic.200300788;
RA   Secko D.M., Insall R.H., Spiegelman G.B., Weeks G.;
RT   "The identification of Dictyostelium phosphoproteins altered in response to
RT   the activation of RasG.";
RL   Proteomics 4:2629-2639(2004).
CC   -!- FUNCTION: Catalyzes the transfer of PtdIns and phosphatidylcholine
CC       between membranes.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10769190}. Golgi
CC       apparatus {ECO:0000269|PubMed:10769190}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout growth and development.
CC       {ECO:0000269|PubMed:10769190}.
CC   -!- PTM: Phosphorylated in response to activation of rasG.
CC       {ECO:0000269|PubMed:15352238}.
CC   -!- SIMILARITY: Belongs to the PtdIns transfer protein family. PI transfer
CC       class I subfamily. {ECO:0000305}.
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DR   EMBL; AF205061; AAF74409.1; -; mRNA.
DR   EMBL; AAFI02000152; EAL62395.1; -; Genomic_DNA.
DR   RefSeq; XP_635910.1; XM_630818.1.
DR   AlphaFoldDB; Q9NCL8; -.
DR   SMR; Q9NCL8; -.
DR   STRING; 44689.DDB0201633; -.
DR   PaxDb; Q9NCL8; -.
DR   EnsemblProtists; EAL62395; EAL62395; DDB_G0290069.
DR   GeneID; 8627476; -.
DR   KEGG; ddi:DDB_G0290069; -.
DR   dictyBase; DDB_G0290069; pitA.
DR   eggNOG; KOG3668; Eukaryota.
DR   HOGENOM; CLU_046509_0_0_1; -.
DR   InParanoid; Q9NCL8; -.
DR   OMA; YCRTSKY; -.
DR   PhylomeDB; Q9NCL8; -.
DR   Reactome; R-DDI-1483196; PI and PC transport between ER and Golgi membranes.
DR   PRO; PR:Q9NCL8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0071944; C:cell periphery; IDA:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:dictyBase.
DR   GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR   GO; GO:0008525; F:phosphatidylcholine transporter activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0008526; F:phosphatidylinositol transfer activity; IDA:dictyBase.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR001666; PI_transfer.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   PANTHER; PTHR10658; PTHR10658; 1.
DR   Pfam; PF02121; IP_trans; 1.
DR   PRINTS; PR00391; PITRANSFER.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Golgi apparatus; Lipid-binding; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..264
FT                   /note="Phosphatidylinositol transfer protein 1"
FT                   /id="PRO_0000328406"
FT   REGION          151..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          238..264
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  31157 MW;  62963142E8621831 CRC64;
     MLIREFRVVL PLTVEEYRVG QLYSVAKTSS QETSNGEGVE VLVNEPYKEP EHEGQYTHKI
     YHLGSRLPGW IRALIPSSAL KLEEKAWNAY PYCKTVLKSP FLGEKFTFII ESRHAQDNCK
     TENIHNLSEK ELKERTVEVI DITKPIKDPK NYKETEDPTK IRSEKANRGP LEEEKWREST
     EMPIMTCYKL VTVEFKYFGF QTKVENFMMG IEFDLFTKFH RQVYCWLDEW FGMSMDDVRA
     FELKTKEDLK KKLEEKDENK AAEK