PITP2_DICDI
ID PITP2_DICDI Reviewed; 259 AA.
AC Q9NCL7; Q555Z4; Q86A75; Q86A76;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Phosphatidylinositol transfer protein 2;
DE Short=PtdIns transfer protein 2;
DE AltName: Full=DdPITP2;
GN Name=pitB; ORFNames=DDB_G0274579;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], ACTIVITY AS PHOSPHATIDYLINOSITOL TRANSFER
RP PROTEIN, AND SUBCELLULAR LOCATION.
RC STRAIN=AX3;
RX PubMed=10769190; DOI=10.1042/bj3470837;
RA Swigart P., Insall R., Wilkins A., Cockcroft S.;
RT "Purification and cloning of phosphatidylinositol transfer proteins from
RT Dictyostelium discoideum: homologues of both mammalian PITPs and
RT Saccharomyces cerevisiae sec14p are found in the same cell.";
RL Biochem. J. 347:837-843(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP DEVELOPMENTAL STAGE.
RC STRAIN=AX4;
RX PubMed=12796308; DOI=10.1128/ec.2.3.627-637.2003;
RA Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S.,
RA Morio T., Urushihara H., Tanaka Y., Loomis W.F.;
RT "Changing patterns of gene expression in Dictyostelium prestalk cell
RT subtypes recognized by in situ hybridization with genes from microarray
RT analyses.";
RL Eukaryot. Cell 2:627-637(2003).
CC -!- FUNCTION: Catalyzes the transfer of PtdIns and phosphatidylcholine
CC between membranes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10769190}. Golgi
CC apparatus {ECO:0000269|PubMed:10769190}.
CC -!- DEVELOPMENTAL STAGE: Expressed during development stage, in prespore
CC cells. {ECO:0000269|PubMed:12796308}.
CC -!- SIMILARITY: Belongs to the PtdIns transfer protein family. PI transfer
CC class IIA subfamily. {ECO:0000305}.
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DR EMBL; AF205062; AAF74410.1; -; mRNA.
DR EMBL; AAFI02000012; EAL70182.1; -; Genomic_DNA.
DR RefSeq; XP_643916.1; XM_638824.1.
DR AlphaFoldDB; Q9NCL7; -.
DR SMR; Q9NCL7; -.
DR STRING; 44689.DDB0219979; -.
DR PaxDb; Q9NCL7; -.
DR PRIDE; Q9NCL7; -.
DR EnsemblProtists; EAL70182; EAL70182; DDB_G0274579.
DR GeneID; 8619343; -.
DR KEGG; ddi:DDB_G0274579; -.
DR dictyBase; DDB_G0274579; pitB.
DR eggNOG; KOG3668; Eukaryota.
DR HOGENOM; CLU_046509_3_0_1; -.
DR InParanoid; Q9NCL7; -.
DR OMA; VQPVMTC; -.
DR PhylomeDB; Q9NCL7; -.
DR Reactome; R-DDI-1483226; Synthesis of PI.
DR PRO; PR:Q9NCL7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0071944; C:cell periphery; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:dictyBase.
DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR GO; GO:0008525; F:phosphatidylcholine transporter activity; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0008526; F:phosphatidylinositol transfer activity; IDA:dictyBase.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR001666; PI_transfer.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR10658; PTHR10658; 1.
DR Pfam; PF02121; IP_trans; 1.
DR PRINTS; PR00391; PITRANSFER.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Golgi apparatus; Lipid-binding; Reference proteome;
KW Transport.
FT CHAIN 1..259
FT /note="Phosphatidylinositol transfer protein 2"
FT /id="PRO_0000328407"
FT COILED 231..259
FT /evidence="ECO:0000255"
SQ SEQUENCE 259 AA; 30006 MW; 386F288D6A53C3E7 CRC64;
MLIKEYRMVL PLTVEEYQIA QLYMVAKKSK ESTKGGEGIE IIKNEPFDNE KGKGQYTEKI
IYLANSLPRF AAAILPSSAL KIEEKAWNAY PYCKTEYSCP FFGEKLVLSI ESMHLPGRGE
VENALKCDAE TLKQRHVDFI DIANDQPKEY IKEEDPKIFK SVKTERGPLD DPKWRDKVEP
VMTCYKLVHA EFKYWGFQTK VENVIQDTGV RDVLLKAHRA LFCWIDEWFG LTIEDIRKIE
EETKAELAKK LEENKAANK
