ID   PITP4_DICDI             Reviewed;         331 AA.
AC   Q54D93;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Phosphatidylinositol transfer protein 4;
DE            Short=PtdIns transfer protein 4;
DE   AltName: Full=DdPITP4;
GN   Name=pitD; ORFNames=DDB_G0292426;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the transfer of PtdIns and phosphatidylcholine
CC       between membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PtdIns transfer protein family. PI transfer
CC       class IIA subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000190; EAL61192.2; -; Genomic_DNA.
DR   RefSeq; XP_629603.2; XM_629601.2.
DR   AlphaFoldDB; Q54D93; -.
DR   SMR; Q54D93; -.
DR   STRING; 44689.DDB0237592; -.
DR   PaxDb; Q54D93; -.
DR   EnsemblProtists; EAL61192; EAL61192; DDB_G0292426.
DR   GeneID; 8628663; -.
DR   KEGG; ddi:DDB_G0292426; -.
DR   dictyBase; DDB_G0292426; pitD.
DR   eggNOG; KOG3668; Eukaryota.
DR   HOGENOM; CLU_046509_2_0_1; -.
DR   InParanoid; Q54D93; -.
DR   OMA; DIADNSC; -.
DR   PhylomeDB; Q54D93; -.
DR   Reactome; R-DDI-1483226; Synthesis of PI.
DR   PRO; PR:Q54D93; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR   GO; GO:0008525; F:phosphatidylcholine transporter activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0008526; F:phosphatidylinositol transfer activity; IBA:GO_Central.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR001666; PI_transfer.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   PANTHER; PTHR10658; PTHR10658; 1.
DR   Pfam; PF02121; IP_trans; 1.
DR   PRINTS; PR00391; PITRANSFER.
PE   3: Inferred from homology;
KW   Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..331
FT                   /note="Phosphatidylinositol transfer protein 4"
FT                   /id="PRO_0000328409"
SQ   SEQUENCE   331 AA;  38514 MW;  4D791EDD9A6A6321 CRC64;
     MLIKEYRITL PFTKEEYRLG QKYMTARKTH ESSNAGDNVQ LLEKSSFTDK NGVKGTFTHK
     VFLLKKSLPR YASAILPKSA LKIEEKSWNS YPNTKTIYSC PFFGEKFYLC IESIHKDGRD
     EEENVFGLSK DILKKRIVDH VDIARDEVEG KDVKTDEDPR MFKSKLTGRG PLTSPNWRKE
     VNPAMVVYKL VTVNFNYWGF QNRVENLVQT NGLREVFLKA HRSLFCWMDE WIDLSEEQIE
     QFEQSTYQLM MNNTIENKLN EDIKNMNISE KKGNQQNTYS KGDFKCPNVN CQHVCSECKH
     MLMTTTTTTT KTVTETTTTV QSPICYRNMV C