PITX1_CHICK
ID PITX1_CHICK Reviewed; 311 AA.
AC P56673; O93358;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Pituitary homeobox 1;
DE AltName: Full=Homeobox protein PITX1;
DE AltName: Full=Paired-like homeodomain transcription factor 1;
DE AltName: Full=cPTX1;
GN Name=PITX1; Synonyms=PTX1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Pituitary;
RX PubMed=9226452; DOI=10.1242/dev.124.14.2807;
RA Lanctot C., Lamolet B., Drouin J.;
RT "The bicoid-related homeoprotein Ptx1 defines the most anterior domain of
RT the embryo and differentiates posterior from anterior lateral mesoderm.";
RL Development 124:2807-2817(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9655805; DOI=10.1242/dev.125.15.2825;
RA Logan M., Simon H.-G., Tabin C.;
RT "Differential regulation of T-box and homeobox transcription factors
RT suggests roles in controlling chick limb-type identity.";
RL Development 125:2825-2835(1998).
RN [3]
RP FUNCTION.
RX PubMed=23995701; DOI=10.1101/gr.157610.113;
RA Ibrahim D.M., Hansen P., Roedelsperger C., Stiege A.C., Doelken S.C.,
RA Horn D., Jaeger M., Janetzki C., Krawitz P., Leschik G., Wagner F.,
RA Scheuer T., Schmidt-von Kegler M., Seemann P., Timmermann B.,
RA Robinson P.N., Mundlos S., Hecht J.;
RT "Distinct global shifts in genomic binding profiles of limb malformation-
RT associated HOXD13 mutations.";
RL Genome Res. 23:2091-2102(2013).
CC -!- FUNCTION: Sequence-specific transcription factor that binds gene
CC promoters and activates their transcription. May play a role in the
CC development of anterior structures, and in particular, the brain and
CC facies and in specifying the identity or structure of hindlimb. Acts as
CC a transcriptional activator by binding to promoter sequences with a
CC TAAT/GCC core motif. {ECO:0000269|PubMed:23995701,
CC ECO:0000269|PubMed:9226452, ECO:0000269|PubMed:9655805}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in primordial Rathke pouch, oral
CC epithelium, first branchial arch, duodenum, and hindlimb.
CC -!- DEVELOPMENTAL STAGE: In the head region, first detected in 10-somite
CC embryos in the stomodeum and rostral foregut. At day 3, expressed in
CC Rathke pouch, in the mandibular and oral epithelia, in the foregut
CC endoderm and in the posterior lateral plate mesoderm. Expression is
CC maintained in these structures in later stages and at day 5, can be
CC seen in the distal portion of the hindlimb.
CC {ECO:0000269|PubMed:9226452}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AF069397; AAC23684.1; -; mRNA.
DR AlphaFoldDB; P56673; -.
DR SMR; P56673; -.
DR STRING; 9031.ENSGALP00000009413; -.
DR VEuPathDB; HostDB:geneid_374201; -.
DR eggNOG; KOG0486; Eukaryota.
DR HOGENOM; CLU_030301_0_0_1; -.
DR InParanoid; P56673; -.
DR OrthoDB; 1432356at2759; -.
DR PhylomeDB; P56673; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR016233; Homeobox_Pitx/unc30.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR PIRSF; PIRSF000563; Homeobox_protein_Pitx/Unc30; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..311
FT /note="Pituitary homeobox 1"
FT /id="PRO_0000049221"
FT DNA_BIND 88..147
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..277
FT /note="Interaction with PIT-1"
FT /evidence="ECO:0000250"
FT MOTIF 278..291
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT MOTIF 284..288
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 21..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 52
FT /note="D -> E (in Ref. 2; AAC23684)"
FT /evidence="ECO:0000305"
FT CONFLICT 60..65
FT /note="ESRKTR -> GEQKN (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 69..77
FT /note="Missing (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="A -> R (in Ref. 2; AAC23684)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="N -> NS (in Ref. 2; AAC23684)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 34473 MW; 28758C05985F2719 CRC64;
MDSFKGGMNL ERLPESLRPQ PSHDMASSFH LQRSSEPRDP IENSASESSD TDVPEKERSE
SRKTREDGGA GSAGCTGAAD DPAKKKKQRR QRTHFTSQQL QELEATFQRN RYPDMSMREE
IAVWTNLTEP RVRVWFKNRR AKWRKRERNQ QMDLCKNGYV PQFSGLMQPY DDMYAGYPYN
NWATKSLTPA PLSTKSFTFF NSMSPLSSQS MFSAPSSISS MNMPSGMGHS AVPGMANSGL
NNINNISGSS LNSAMSSPAC PYGPPGSPYS VYRDTCNSSL ASLALKSKQH SSFGYSSLQS
PGSSLNACQY N
