ID   PITX3_XENLA             Reviewed;         292 AA.
AC   Q9I8K3; Q9DF51;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Pituitary homeobox 3;
DE   AltName: Full=Homeobox protein PITX3;
DE            Short=XPitx-3;
DE            Short=xPitx3;
DE   AltName: Full=Paired-like homeodomain transcription factor 3;
GN   Name=pitx3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Khosrowshahian F., Chang W.Y., Lum N., Fujiki K., Crawford M.J.;
RT   "xPitx3 exhibits dynamic expression during sensory placode development in
RT   Xenopus.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Thomas H., Tomas P.;
RT   "Xpitx-3: a homeobox gene expressed in the pituitary anlage and lens
RT   epithelium.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator which may play a role in the
CC       differentiation and maintenance of meso-diencephalic dopaminergic
CC       (mdDA) neurons. May play a role in the normal lens development and
CC       differentiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF265671; AAF97592.1; -; mRNA.
DR   EMBL; AF297713; AAG15383.1; -; mRNA.
DR   RefSeq; NP_001079212.1; NM_001085743.1.
DR   RefSeq; NP_001082023.1; NM_001088554.1.
DR   AlphaFoldDB; Q9I8K3; -.
DR   SMR; Q9I8K3; -.
DR   GeneID; 373824; -.
DR   GeneID; 398183; -.
DR   KEGG; xla:373824; -.
DR   KEGG; xla:398183; -.
DR   CTD; 373824; -.
DR   CTD; 398183; -.
DR   Xenbase; XB-GENE-486166; pitx3.L.
DR   Xenbase; XB-GENE-17345022; pitx3.S.
DR   OrthoDB; 1432356at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 373824; Expressed in muscle tissue and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR016233; Homeobox_Pitx/unc30.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PIRSF; PIRSF000563; Homeobox_protein_Pitx/Unc30; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..292
FT                   /note="Pituitary homeobox 3"
FT                   /id="PRO_0000049232"
FT   DNA_BIND        60..119
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           254..267
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           260..264
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        10..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        55
FT                   /note="I -> T (in Ref. 2; AAG15383)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        170
FT                   /note="Q -> P (in Ref. 2; AAG15383)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="T -> P (in Ref. 2; AAG15383)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        229
FT                   /note="T -> N (in Ref. 2; AAG15383)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   292 AA;  32585 MW;  D9F9ABBA90088FD3 CRC64;
     MDFNLLTDSE ARSPALSLSD SGTPQHDHSC KGQEHSDTEK SQQNQTDDSN PEDGILKKKQ
     RRQRTHFTSQ QLQELEATFQ RNRYPDMSTR EEIAVWTNLT EARVRVWFKN RRAKWRKRER
     NQQAELCKNS FGAQFNGLMQ PYDDMYSGYS YNNWATKGLA TSPLSAKSFQ FFNSMNVSPL
     SSQPMFSPPN SIASMTMTSS MVPSAVTGVP GSSLNNLGNI NNLNSPSLTS AVSASACPYA
     STASPYMYRD TCNSSLASLR LKAKQHANFT YPAVQTPASN LSPCQYAVDR PV