ID   PIT_MYCLE               Reviewed;         414 AA.
AC   Q50173;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Probable low-affinity inorganic phosphate transporter;
GN   Name=pit; Synonyms=pitA; OrderedLocusNames=ML2260;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Low-affinity inorganic phosphate transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC       2.A.20) family. Pit subfamily. {ECO:0000305}.
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DR   EMBL; U15187; AAA63139.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31216.1; -; Genomic_DNA.
DR   PIR; H87191; H87191.
DR   RefSeq; NP_302471.1; NC_002677.1.
DR   RefSeq; WP_010908791.1; NC_002677.1.
DR   AlphaFoldDB; Q50173; -.
DR   SMR; Q50173; -.
DR   STRING; 272631.ML2260; -.
DR   EnsemblBacteria; CAC31216; CAC31216; CAC31216.
DR   KEGG; mle:ML2260; -.
DR   PATRIC; fig|272631.5.peg.4315; -.
DR   Leproma; ML2260; -.
DR   eggNOG; COG0306; Bacteria.
DR   HOGENOM; CLU_015355_1_0_11; -.
DR   OMA; GYDITRT; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001204; Phos_transporter.
DR   PANTHER; PTHR11101; PTHR11101; 1.
DR   Pfam; PF01384; PHO4; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..414
FT                   /note="Probable low-affinity inorganic phosphate
FT                   transporter"
FT                   /id="PRO_0000080791"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          377..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  42728 MW;  833323BC29BE2094 CRC64;
     MNINLFLLII VVITALAFDF TNGFHDTGNA MATSIASGAL APKVAVFFSA ILNLVGAFLS
     TAVAATIAKD LIEADLVTLE LVFAGLVGGI VWNLLTWLLG IPSSSSHALI GGIVGARIAA
     VGGHGVIWSG VISKVIIPAI IAALLAIVVG AVATWLVYAI TRSVPAMSTD TRFRRGQIGS
     ASLVSLAHGT NDAQKTMGVI FLALMSYGTV SKTASTPPLW VIVCCAIAIA AGTYLGGWRI
     IRTLGKGMVE IKPPQGMAAE SSSAAVILLS AHFGYALSTT QVCTGSVLGS GLGKPGGEVR
     WGVAGRMATA WLVTLPLAGS VGAVTYWIVH LIGGYPGAVI GFSLLVAASV AIYIRSRKVK
     VDHKNVNENW EGSLTAGLDG SDEHKPHSDV GPKLSATLPR YRSSHHTVGV RNAS