ID   PIWI1_SCHMD             Reviewed;         808 AA.
AC   Q2Q5Y9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Piwi-like protein 1;
DE   AltName: Full=SMEDWI-1;
GN   Name=wi-1;
OS   Schmidtea mediterranea (Freshwater planarian flatworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Schmidtea.
OX   NCBI_TaxID=79327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=CIW4;
RX   PubMed=16311336; DOI=10.1126/science.1116110;
RA   Reddien P.W., Oviedo N.J., Jennings J.R., Jenkin J.C., Sanchez Alvarado A.;
RT   "SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.";
RL   Science 310:1327-1330(2005).
CC   -!- TISSUE SPECIFICITY: Expressed in dividing adult somatic stem cells
CC       (neoblasts). {ECO:0000269|PubMed:16311336}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Piwi subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ186985; ABB77337.1; -; mRNA.
DR   AlphaFoldDB; Q2Q5Y9; -.
DR   SMR; Q2Q5Y9; -.
DR   PRIDE; Q2Q5Y9; -.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   RNA-mediated gene silencing.
FT   CHAIN           1..808
FT                   /note="Piwi-like protein 1"
FT                   /id="PRO_0000227973"
FT   DOMAIN          207..333
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          492..790
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          300..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  92939 MW;  A910F622398E956B CRC64;
     MDSTNVTTDP NLRPRRGGLQ RRFAIIEPAL QPDTVTDKIG KDGRVVSLKS NYANFNIKVE
     GPFYMYDVVM ENKSIRTKLE LLLAYANSKN NGQPFCFDGR RLFTTSKWHS DEDTENLVIK
     DVEISIRLLT TFLKNSEEYY QMINIVFNNI QIFMGQEKIG RQFFLGSNCE SGGIREGPSF
     FKMDNFKILG GYSTTITRGT NENGTASTLL YLERINRVLN ENNVVSVYRR DQIDQLIGRD
     IITKYNNKTY RISDIKEMDV NDEVQLGDKK ISYLNYFKQR YNINLKNDKQ PFVISRVKRS
     MVRPKEKTEN EPEGPTETDQ SLSIPGELCY LCGFSDSERS NINLQKNLGT VLKREPRERL
     NDIRDFCKWT GAGKSKDYMK SWGMCIEEQP ITIRGRELAP VDIFSNEVKI NTKIPDDWKF
     GEIKFDVPKG TAHRFGVLVV DRNPSHFNNF IEDVKREIGR LRINYTMDSI SSCRSNEVED
     ALTDFIRVSK VHMALVFIPD DKVYAKVKNF TMSTGLLTQC VTQRNGSNRD DRRRKTVADK
     SVMQMFSKLG YDPWGINLKM APTMIVGLDT FHSKTGKRSV QASVFSISAK FSQYISFVNS
     SKGKNEFHEN LGKNFLTALT TFQNKFNTMP LRLIIYRDGV GDSQLAFTKK FETDAVMKMI
     EKIYENQTLP QIIYVVVKKR ISVKFFKDGA NPNPGTVVDE KIVKPNFYEF YLVSQKTTKG
     TASPTNYNVL MDTKFTNKKT NEVSVMSPSV LQQITYSLTH LYFNWMGTIR VPVPTHYAHR
     LAELVGKIHR GVTPPAINDR IRERLFYL