PIWI2_SCHMD
ID PIWI2_SCHMD Reviewed; 833 AA.
AC Q2Q5Y8;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Piwi-like protein 2;
DE AltName: Full=SMEDWI-2;
GN Name=wi-2;
OS Schmidtea mediterranea (Freshwater planarian flatworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC Dugesiidae; Schmidtea.
OX NCBI_TaxID=79327;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=CIW4;
RX PubMed=16311336; DOI=10.1126/science.1116110;
RA Reddien P.W., Oviedo N.J., Jennings J.R., Jenkin J.C., Sanchez Alvarado A.;
RT "SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.";
RL Science 310:1327-1330(2005).
CC -!- FUNCTION: Required for the production of functional progeny from adult
CC somatic stem cells (neoblasts). {ECO:0000269|PubMed:16311336}.
CC -!- TISSUE SPECIFICITY: Expressed in dividing adult stem cells.
CC {ECO:0000269|PubMed:16311336}.
CC -!- SIMILARITY: Belongs to the argonaute family. Piwi subfamily.
CC {ECO:0000305}.
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DR EMBL; DQ186986; ABB77338.1; -; mRNA.
DR AlphaFoldDB; Q2Q5Y8; -.
DR SMR; Q2Q5Y8; -.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; SSF101690; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; RNA-mediated gene silencing.
FT CHAIN 1..833
FT /note="Piwi-like protein 2"
FT /id="PRO_0000227974"
FT DOMAIN 220..330
FT /note="PAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT DOMAIN 515..815
FT /note="Piwi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT REGION 313..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 95827 MW; 354F1612FA590023 CRC64;
MEEIPVKVAK LEANGSETRG KMGNRGGLRG TFRIVEPNLQ PADITEKTGN IGRTVKLQSN
FTKFSVLRSE KFMMYDSVFS QVGLSPKVKL QFIVRVCQEN KLPGAFCFDG RRLFTSEKWH
GESDIQEFSH DEKKMTLRLV STILPETEEY YQMINVLLNN LQVMLGQERI GKGYFLSPNI
TKDEVPRNSG PTFFETNSFK VLGGFGTTLQ RGTKPTGELT TLLYIERINR VLNDNSVMKA
YNRRSIDQLI GRDIITKYNN KTYRISEIKE MNVDEKFEMG GRTLSYAEYF KERYNIRLTQ
GDQPFVLTRV KKPMRRERKK KDEEGVEKEK EKEAPEEKDM TLNIPGELCF LCGFSDQEKS
NMDLQKNLGC VLKREPRERL DDIPAYCNWI KNSDAATGMC NKWQLKIDNK PLEIEGRELP
PCDVISGGSK INEKMGDDWK FGRVQFDIKR DRKHEIDVVI VDRNDFQYKN FMNDVEQELR
NMRIDARVGK VNTCGPNDVE RCLNDAARSG SGCAKMALVF VPDDRVYAKV KSFTMSTGLL
TQCVTTRNGT NRNDKRRKVV SSKTVMQIFA KFGYDPWTVE IKLRPTMIVG MDTYHNKSSK
KSIQASVFSI NSTFTQYMSF VVNSPKGRQE FHETLGKNFN LALEDFKKRY DILPQRILVF
RDGVGDNQLQ FTKNFEVDAM KPLIENIYKG NGFPVPQIIY VIVKKRVGTK LFNRGNNPNP
GTVVDKEIVK PNFYEFFLVS QRTTKGTATP TNYNVLEDTR LLTKKGTMDP MAPNELQKIT
YALTHLYFNW MGTIRVPVPV HYAHRLAELV GKVHKGSNPV AINERIRNRL FYL