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PIWI2_SCHMD
ID   PIWI2_SCHMD             Reviewed;         833 AA.
AC   Q2Q5Y8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Piwi-like protein 2;
DE   AltName: Full=SMEDWI-2;
GN   Name=wi-2;
OS   Schmidtea mediterranea (Freshwater planarian flatworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Schmidtea.
OX   NCBI_TaxID=79327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=CIW4;
RX   PubMed=16311336; DOI=10.1126/science.1116110;
RA   Reddien P.W., Oviedo N.J., Jennings J.R., Jenkin J.C., Sanchez Alvarado A.;
RT   "SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.";
RL   Science 310:1327-1330(2005).
CC   -!- FUNCTION: Required for the production of functional progeny from adult
CC       somatic stem cells (neoblasts). {ECO:0000269|PubMed:16311336}.
CC   -!- TISSUE SPECIFICITY: Expressed in dividing adult stem cells.
CC       {ECO:0000269|PubMed:16311336}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Piwi subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ186986; ABB77338.1; -; mRNA.
DR   AlphaFoldDB; Q2Q5Y8; -.
DR   SMR; Q2Q5Y8; -.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; RNA-mediated gene silencing.
FT   CHAIN           1..833
FT                   /note="Piwi-like protein 2"
FT                   /id="PRO_0000227974"
FT   DOMAIN          220..330
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          515..815
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          313..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  95827 MW;  354F1612FA590023 CRC64;
     MEEIPVKVAK LEANGSETRG KMGNRGGLRG TFRIVEPNLQ PADITEKTGN IGRTVKLQSN
     FTKFSVLRSE KFMMYDSVFS QVGLSPKVKL QFIVRVCQEN KLPGAFCFDG RRLFTSEKWH
     GESDIQEFSH DEKKMTLRLV STILPETEEY YQMINVLLNN LQVMLGQERI GKGYFLSPNI
     TKDEVPRNSG PTFFETNSFK VLGGFGTTLQ RGTKPTGELT TLLYIERINR VLNDNSVMKA
     YNRRSIDQLI GRDIITKYNN KTYRISEIKE MNVDEKFEMG GRTLSYAEYF KERYNIRLTQ
     GDQPFVLTRV KKPMRRERKK KDEEGVEKEK EKEAPEEKDM TLNIPGELCF LCGFSDQEKS
     NMDLQKNLGC VLKREPRERL DDIPAYCNWI KNSDAATGMC NKWQLKIDNK PLEIEGRELP
     PCDVISGGSK INEKMGDDWK FGRVQFDIKR DRKHEIDVVI VDRNDFQYKN FMNDVEQELR
     NMRIDARVGK VNTCGPNDVE RCLNDAARSG SGCAKMALVF VPDDRVYAKV KSFTMSTGLL
     TQCVTTRNGT NRNDKRRKVV SSKTVMQIFA KFGYDPWTVE IKLRPTMIVG MDTYHNKSSK
     KSIQASVFSI NSTFTQYMSF VVNSPKGRQE FHETLGKNFN LALEDFKKRY DILPQRILVF
     RDGVGDNQLQ FTKNFEVDAM KPLIENIYKG NGFPVPQIIY VIVKKRVGTK LFNRGNNPNP
     GTVVDKEIVK PNFYEFFLVS QRTTKGTATP TNYNVLEDTR LLTKKGTMDP MAPNELQKIT
     YALTHLYFNW MGTIRVPVPV HYAHRLAELV GKVHKGSNPV AINERIRNRL FYL
 
 
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