ID   PIWIL_DUGJA             Reviewed;         818 AA.
AC   Q2PC95;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Piwi-like protein;
GN   Name=iwi;
OS   Dugesia japonica (Planarian).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Dugesia.
OX   NCBI_TaxID=6161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rossi L., Salvetti A., Batistoni R., Deri P., Gremigni V.;
RT   "Characterization of a Iwi gene in planarians.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the argonaute family. Piwi subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ865376; CAI26303.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2PC95; -.
DR   SMR; Q2PC95; -.
DR   PRIDE; Q2PC95; -.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   RNA-mediated gene silencing.
FT   CHAIN           1..818
FT                   /note="Piwi-like protein"
FT                   /id="PRO_0000227972"
FT   DOMAIN          213..323
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          501..800
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
SQ   SEQUENCE   818 AA;  94216 MW;  CE26BE0B11B8A013 CRC64;
     MEIELIRKNL DGIRIERRGG LQKRFRIVEP DLQPNETKDK IGNVGKVVRL QSNFTKFSVN
     KSEKYIMYDT TFSKMGLSPK LKLQILVRIC KEYNLPGSFC YDGRRLFTSD NWTEGSDIKE
     FTIDEKKVSL RLVSTFLSDT EEYYQMINVL LNNLQIIMGQ EKIGKGYFLG SNSNKDNVVK
     NIGPTFFETN NFKVLGGFGT TLQRGTRPNG QLTTLLYIER INRVLNDNSV LVTYNRKNID
     QLIGRDILTK YNNKTYRISE IKEMNINETF EMVGRTLSYA QYFKERYNIN LTTEQQPFVL
     TRVKKIARRD KRKEHNENEA PEDMDLTLNI TGELCFLCGF SDQEKSNIDL QKNLGCVLKR
     GPRERLDDIP SFCDWIKTNN NSQGMSNKWG LKIDNTPLEI EGRELPHCDV ISGGQRINEK
     IKDDWKFGKV QFNVQKGVKH EIDVVIVDRN DSQYGNFLND VEYEIKQLRF DAKIGRVLVC
     SANDVERSLN DVMRSGSGCA KIALVFVPDD RVYAKVKSFT ISTGLLTQCV TTRNGTNRND
     KRRQVVSSKT VMQIFSKFGY DPWTIDIKMR PTMIVGMDTF HNKGSKKSIH ASVFSINSTF
     SQYMSFANSP KGKQEFHDTL SGNFKAALTE FKRIYKILPV RIMVYRDGVG DSQLQFTKQF
     EVDAMKPLVE NIYKENGCQV PQIIYVIVKK RIGTKLFNRG DNANPGTIVD KEIVKPNFFE
     FFLVSQRVTR GTASPTNYNV LEDTRYQNKA GIIEAITPNE LQRITYTLTH LYFNWMGTIR
     VPVPVHYAHK LAELIGKVHK GSTPALINER IRNRLFYL