ID   A6_VACCC                Reviewed;         372 AA.
AC   P20985;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein A6;
GN   ORFNames=A6L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Plays an essential role in immature virion (IV) to mature
CC       virion (MV) transition. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M35027; AAA48123.1; -; Genomic_DNA.
DR   PIR; H42517; H42517.
DR   PDB; 6CB6; X-ray; 1.80 A; A=1-121.
DR   PDB; 6CB7; X-ray; 1.60 A; A=1-121.
DR   PDBsum; 6CB6; -.
DR   PDBsum; 6CB7; -.
DR   SMR; P20985; -.
DR   PRIDE; P20985; -.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR007008; Poxvirus_A6.
DR   Pfam; PF04924; Pox_A6; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Virion.
FT   CHAIN           1..372
FT                   /note="Protein A6"
FT                   /id="PRO_0000099221"
FT   HELIX           2..23
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   HELIX           32..49
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   HELIX           59..67
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   HELIX           71..73
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   HELIX           75..77
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   TURN            78..80
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   HELIX           85..91
FT                   /evidence="ECO:0007829|PDB:6CB7"
FT   HELIX           94..112
FT                   /evidence="ECO:0007829|PDB:6CB7"
SQ   SEQUENCE   372 AA;  43128 MW;  8149CD07AD808D70 CRC64;
     MDKLRVLYDE FVTISKDNLE RETGLSASDV DMDFDLNIFM TLVPVLEKKV CAITPTIEDD
     KIVTMMKYCS YQSFSFWFLK SGAVVKSVYN KLDDVEKEKF VATFRDMLLN VQTLISLNSM
     YTRLRQDTED IVSDSKKIME IVSHLRASTT ENAAYQVLQQ NNSFIISTLN KILSDENYLL
     KIIAVFDSKL ISEKETLNEY KQLYTISSES LVYGIRCVSN LDISSVQLSN NKYVLFVKKM
     LPKIILFQNN DINAQQFANV ISKIYTLIYR QLTSNVDVGC LLTDTIESAK TKISVEKIKQ
     TGINNVQSLI KFISDNKKEY KTIISEEYLS KEDRIITILQ DIVNEHDIKY DNKLLNMRDL
     IVTFRERYSY KF