ID   PK1IP_BOVIN             Reviewed;         392 AA.
AC   Q5EA99;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=p21-activated protein kinase-interacting protein 1;
DE   AltName: Full=PAK1-interacting protein 1;
GN   Name=PAK1IP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the
CC       PAK kinase family, which has been shown to play a positive role in the
CC       regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists
CC       as an inactive homodimer, which is activated by binding of small
CC       GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also
CC       binds to the N-terminus of PAK1, and inhibits the specific activation
CC       of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
CC   -!- SUBUNIT: Interacts with PAK1. {ECO:0000250|UniProtKB:Q9NWT1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
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DR   EMBL; BT020668; AAX08685.1; -; mRNA.
DR   EMBL; BT020670; AAX08687.1; -; mRNA.
DR   RefSeq; NP_001014852.1; NM_001014852.1.
DR   AlphaFoldDB; Q5EA99; -.
DR   SMR; Q5EA99; -.
DR   STRING; 9913.ENSBTAP00000024854; -.
DR   PaxDb; Q5EA99; -.
DR   PeptideAtlas; Q5EA99; -.
DR   GeneID; 505125; -.
DR   KEGG; bta:505125; -.
DR   CTD; 55003; -.
DR   eggNOG; KOG0294; Eukaryota.
DR   InParanoid; Q5EA99; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW   Signal transduction inhibitor; WD repeat.
FT   CHAIN           1..392
FT                   /note="p21-activated protein kinase-interacting protein 1"
FT                   /id="PRO_0000051124"
FT   REPEAT          40..77
FT                   /note="WD 1"
FT   REPEAT          80..118
FT                   /note="WD 2"
FT   REPEAT          121..160
FT                   /note="WD 3"
FT   REPEAT          202..240
FT                   /note="WD 4"
FT   REPEAT          243..284
FT                   /note="WD 5"
FT   REGION          309..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..392
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  44049 MW;  CC2B64D833D3E3F6 CRC64;
     MEVVAGCYEQ VLFGFAVHPE PVGDGHRERW APVADFTHHA HTASLSAVAV NSRFVVTGSK
     DETIHIYDMK KKVDHGALMH HNGTITCLKF HGNRHLISGA EDGLICVWDA RRWECLKSIR
     AHKGHVTFLS IHPSGRLALS VGTDKTLRTW NLVEGRSAFI KNIKQSAHIV EWSPKGEKYV
     VVILNRIDVY QLDTASVSGT ITNERRVSSV TFLSESVLTV AGDEEVVRFF DCDSLTCLSE
     FKAHENRVKD MFSFETPEHH VLVTASSDGF IKMWKLKQDK KVSPSLLCEI NTNARLTCLG
     VWLDRRTDTK ESPPAAAEPA PVSKEQSRRN KEESGHAVQE EEKQPKPDTE KCSLTGDSNK
     PTRGNSLVSA KKRKTVEMLE KKRKKKKIRM MQ