ID   PK1IP_CHICK             Reviewed;         369 AA.
AC   Q5ZKU8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=p21-activated protein kinase-interacting protein 1-like;
DE   AltName: Full=PAK1-interacting protein 1-like;
GN   Name=PAK1IP1; ORFNames=RCJMB04_9b18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the
CC       PAK kinase family, which has been shown to play a positive role in the
CC       regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists
CC       as an inactive homodimer, which is activated by binding of small
CC       GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also
CC       binds to the N-terminus of PAK1, and inhibits the specific activation
CC       of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
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DR   EMBL; AJ719986; CAG31645.1; -; mRNA.
DR   RefSeq; NP_001026170.1; NM_001030999.1.
DR   AlphaFoldDB; Q5ZKU8; -.
DR   SMR; Q5ZKU8; -.
DR   STRING; 9031.ENSGALP00000020742; -.
DR   PaxDb; Q5ZKU8; -.
DR   PRIDE; Q5ZKU8; -.
DR   GeneID; 420850; -.
DR   KEGG; gga:420850; -.
DR   CTD; 55003; -.
DR   VEuPathDB; HostDB:geneid_420850; -.
DR   eggNOG; KOG0294; Eukaryota.
DR   InParanoid; Q5ZKU8; -.
DR   OrthoDB; 824688at2759; -.
DR   PhylomeDB; Q5ZKU8; -.
DR   PRO; PR:Q5ZKU8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW   Signal transduction inhibitor; WD repeat.
FT   CHAIN           1..369
FT                   /note="p21-activated protein kinase-interacting protein 1-
FT                   like"
FT                   /id="PRO_0000051127"
FT   REPEAT          33..70
FT                   /note="WD 1"
FT   REPEAT          73..111
FT                   /note="WD 2"
FT   REPEAT          114..153
FT                   /note="WD 3"
FT   REPEAT          195..233
FT                   /note="WD 4"
FT   REPEAT          236..278
FT                   /note="WD 5"
FT   REGION          311..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..348
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  41232 MW;  8A4132C1C33F6CC9 CRC64;
     MELVAGCYEQ ILFGFAARPG EPWTVTPDFT HHAHTASLSA VAVNSKYVVT GSRDESIQIY
     DMRKKVEHGA LLQHNGTITC LEFYGTAHLL SGAEDGLICI WNTKRWECLK SIKAHKGHVT
     SLSIHPSGKL ALSVGTDKTL RTWNLVEGRS AFIKNLKQNA HIIKWSPDGE KYVTVITNKV
     DIYKLDTASI TGTITIEKRI SSIRFITDSV LAIAGDDEII RFYSCDSQKC LCEFKARENR
     IKDIYSFERE GQHVIVTASS DGYIKVWNLD LNKINNVPSL LCEVSTKARL TCLAVWLDQA
     SEMKENCGKA ATSTEANESE KPSAVKKKKV CGMNKSGKLT KQRRRIVPAK RKLEAPLQKK
     KKKKQNSSE