ID   PK1IP_DANRE             Reviewed;         368 AA.
AC   Q6TNS2; Q6NYY5; Q7ZW90;
DT   02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=p21-activated protein kinase-interacting protein 1-like;
DE   AltName: Full=PAK1-interacting protein 1-like;
GN   Name=pak1ip1; ORFNames=zgc:56683;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the
CC       PAK kinase family, which has been shown to play a positive role in the
CC       regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists
CC       as an inactive homodimer, which is activated by binding of small
CC       GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also
CC       binds to the N-terminus of PAK1, and inhibits the specific activation
CC       of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
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DR   EMBL; AY391445; AAQ91257.1; -; mRNA.
DR   EMBL; BC049528; AAH49528.2; -; mRNA.
DR   EMBL; BC066416; AAH66416.2; -; mRNA.
DR   RefSeq; NP_957239.2; NM_200945.2.
DR   AlphaFoldDB; Q6TNS2; -.
DR   SMR; Q6TNS2; -.
DR   STRING; 7955.ENSDARP00000065337; -.
DR   PaxDb; Q6TNS2; -.
DR   Ensembl; ENSDART00000065338; ENSDARP00000065337; ENSDARG00000044488.
DR   GeneID; 336470; -.
DR   KEGG; dre:336470; -.
DR   CTD; 55003; -.
DR   ZFIN; ZDB-GENE-030131-8414; pak1ip1.
DR   eggNOG; KOG0294; Eukaryota.
DR   GeneTree; ENSGT00390000001263; -.
DR   HOGENOM; CLU_031466_2_0_1; -.
DR   InParanoid; Q6TNS2; -.
DR   OMA; WDIKSAH; -.
DR   OrthoDB; 824688at2759; -.
DR   PhylomeDB; Q6TNS2; -.
DR   TreeFam; TF326684; -.
DR   PRO; PR:Q6TNS2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 24.
DR   Bgee; ENSDARG00000044488; Expressed in somite and 29 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW   Signal transduction inhibitor; WD repeat.
FT   CHAIN           1..368
FT                   /note="p21-activated protein kinase-interacting protein 1-
FT                   like"
FT                   /id="PRO_0000051128"
FT   REPEAT          45..82
FT                   /note="WD 1"
FT   REPEAT          85..123
FT                   /note="WD 2"
FT   REPEAT          126..165
FT                   /note="WD 3"
FT   REPEAT          207..245
FT                   /note="WD 4"
FT   REPEAT          248..289
FT                   /note="WD 5"
FT   CONFLICT        9
FT                   /note="G -> E (in Ref. 2; AAH49528)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        56
FT                   /note="S -> N (in Ref. 2; AAH66416)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="Y -> C (in Ref. 2; AAH49528)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   368 AA;  40901 MW;  5DA4D6F902F7E99D CRC64;
     MSECFTVMGD HIELVAGCYE QIVFGYRVCP ADEEWTIEPT FTHHAHTASL NAVSSSNQFI
     ATGSKDETIQ LYDMCKKTEH GALLHHDGTI SCLEFYGTSH LLSGGQDGLI CVWSTKKWEC
     LKTIRAHKGQ VTSLSVHPSG KLALSVGTDK TLRTWNLIEG RSAFIKNIKQ NAEIVLWSPD
     GDKYAVVVND KVDIYTLDSA TIIGTIAFTK RISCLKFLKN SLLAVGGDDE SVRIYDVTSQ
     KCVCEFKAHE NRVKAIESFM KDDFCVLVTA SNDGFIKLWK LNLESIESPT LLGQLNTTAR
     LTCLCVWMPG ETKETAEQPA QATTSEDVLD PLVPVRSKRV RILGEEVIME DEKGSKTQGK
     KKKRQKVQ