ID   PK1IP_XENLA             Reviewed;         363 AA.
AC   Q68FJ6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=p21-activated protein kinase-interacting protein 1-like;
DE   AltName: Full=PAK1-interacting protein 1-like;
GN   Name=pak1ip1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the
CC       PAK kinase family, which has been shown to play a positive role in the
CC       regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists
CC       as an inactive homodimer, which is activated by binding of small
CC       GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also
CC       binds to the N-terminus of PAK1, and inhibits the specific activation
CC       of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NWT1}.
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DR   EMBL; BC079760; AAH79760.1; -; mRNA.
DR   RefSeq; NP_001087421.1; NM_001093952.1.
DR   AlphaFoldDB; Q68FJ6; -.
DR   SMR; Q68FJ6; -.
DR   DNASU; 447245; -.
DR   GeneID; 447245; -.
DR   KEGG; xla:447245; -.
DR   CTD; 447245; -.
DR   Xenbase; XB-GENE-866133; pak1ip1.S.
DR   OrthoDB; 824688at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 447245; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW   Signal transduction inhibitor; WD repeat.
FT   CHAIN           1..363
FT                   /note="p21-activated protein kinase-interacting protein 1-
FT                   like"
FT                   /id="PRO_0000051129"
FT   REPEAT          38..75
FT                   /note="WD 1"
FT   REPEAT          78..116
FT                   /note="WD 2"
FT   REPEAT          119..158
FT                   /note="WD 3"
FT   REPEAT          200..238
FT                   /note="WD 4"
FT   REPEAT          241..282
FT                   /note="WD 5"
FT   REGION          309..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  40531 MW;  354DC7B373D0965A CRC64;
     MEESIKLLVG CYEQVLFGYR VHREGEQWLS SADFTHHAHT ASVSVLAVNN RFVATGSRDE
     TIQIYDMKKK VEHGALLHHN GTITCLEFYG NTHLLSGAED GLICVWNTKK WECQQTFKAH
     KGQVLSLSIH PSGKLALSVG TDKTLRTWNL VEGRSAFIKN IKKNAHIVHW SPSGEKYVVV
     IHDTVDVYQL ETAAVVGTIN NPKRISSAQF ITDALIAVAG DEEVIRLYDT ASQKCVCEFK
     AHENRVKNLH VIELQGTHVV VSSSSDGYIK MWRIDMEKVQ TSPSLLCEVS TSARLTCLSA
     WLPSGVDHKE KSNTAVTASA VKDCDRPKKK KAQNETTDKE ASETQVVHKK RKPETKQKKK
     KPS