PK21A_CORGL
ID PK21A_CORGL Reviewed; 320 AA.
AC Q8NRX4; Q6M6N1;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Putative GDP-polyphosphate phosphotransferase PKK2A {ECO:0000250|UniProtKB:O05877};
DE EC=2.7.4.- {ECO:0000250|UniProtKB:O05877};
GN Name=pkk2A {ECO:0000303|PubMed:17545325};
GN OrderedLocusNames=Cgl0917 {ECO:0000312|EMBL:BAB98310.1};
OS Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS JCM 1318 / LMG 3730 / NCIMB 10025).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196627;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA Ikeda M., Nakagawa S.;
RT "The Corynebacterium glutamicum genome: features and impacts on
RT biotechnological processes.";
RL Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=17545325; DOI=10.1128/aem.00600-07;
RA Lindner S.N., Vidaurre D., Willbold S., Schoberth S.M., Wendisch V.F.;
RT "NCgl2620 encodes a class II polyphosphate kinase in Corynebacterium
RT glutamicum.";
RL Appl. Environ. Microbiol. 73:5026-5033(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[phosphate](n) + GTP = [phosphate](n+1) + GDP;
CC Xref=Rhea:RHEA:55412, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280,
CC ChEBI:CHEBI:16838, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000250|UniProtKB:O05877};
CC -!- DISRUPTION PHENOTYPE: Deletion of the gene does not affect
CC significantly the cellular polyP content.
CC {ECO:0000269|PubMed:17545325}.
CC -!- SIMILARITY: Belongs to the polyphosphate kinase 2 (PPK2) family. Class
CC I subfamily. {ECO:0000305}.
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DR EMBL; BA000036; BAB98310.1; -; Genomic_DNA.
DR RefSeq; NP_600145.1; NC_003450.3.
DR RefSeq; WP_011013972.1; NC_006958.1.
DR AlphaFoldDB; Q8NRX4; -.
DR SMR; Q8NRX4; -.
DR STRING; 196627.cg1046; -.
DR PRIDE; Q8NRX4; -.
DR KEGG; cgl:Cgl0917; -.
DR PATRIC; fig|196627.13.peg.903; -.
DR eggNOG; COG2326; Bacteria.
DR HOGENOM; CLU_048699_3_0_11; -.
DR OMA; NPRICRV; -.
DR Proteomes; UP000000582; Chromosome.
DR GO; GO:0008976; F:polyphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016898; Polyphosphate_phosphotransfera.
DR InterPro; IPR022488; PPK2-related.
DR InterPro; IPR022486; PPK2_PA0141.
DR Pfam; PF03976; PPK2; 1.
DR PIRSF; PIRSF028756; PPK2_prd; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03707; PPK2_P_aer; 1.
PE 3: Inferred from homology;
KW Kinase; Reference proteome; Transferase.
FT CHAIN 1..320
FT /note="Putative GDP-polyphosphate phosphotransferase PKK2A"
FT /id="PRO_0000442583"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 37614 MW; BCAEBF642B19B658 CRC64;
MRKKKDGQNL PDFRKNPPKL DKKAYEKELK RLQAELVDLQ QWVVETGARV VIVMEGRDAA
GKGSAIKRIT QYLNPRSARI EALPTPNSRE KGQWYFQRYI EKLPTAGEIV IFDRSWYNRA
GVERVMGFCT SQEYRRFLHQ APIFERLLVE DGIHLRKYWF SVSDEEQIER FEDRLSDPLR
RWKLSPMDLQ SITRWEDYSR AKDEMFIHTD IPSAPWYTVE SEDKKRSRIN VISHLLSTIP
YEKIDRPLPE IPHRPDSESD YVRPPRDEFR YVPDVAAHLE EERIKKEEKA KKAKKPAKAA
GKNSDKQKSS GGKGKKKSKK
