ID   PK21B_PSEAE             Reviewed;         304 AA.
AC   Q9I154;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=ADP-polyphosphate phosphotransferase {ECO:0000305};
DE            EC=2.7.4.- {ECO:0000269|PubMed:19001261};
DE   AltName: Full=Polyphosphate kinase PPK2 2 {ECO:0000305};
GN   OrderedLocusNames=PA2428 {ECO:0000312|EMBL:AAG05816.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=19001261; DOI=10.1073/pnas.0807563105;
RA   Nocek B., Kochinyan S., Proudfoot M., Brown G., Evdokimova E., Osipiuk J.,
RA   Edwards A.M., Savchenko A., Joachimiak A., Yakunin A.F.;
RT   "Polyphosphate-dependent synthesis of ATP and ADP by the family-2
RT   polyphosphate kinases in bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:17730-17735(2008).
CC   -!- FUNCTION: Uses inorganic polyphosphate (polyP) as a donor to convert
CC       ADP to ATP. {ECO:0000269|PubMed:19001261}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[phosphate](n) + ATP = [phosphate](n+1) + ADP;
CC         Xref=Rhea:RHEA:19573, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280,
CC         ChEBI:CHEBI:16838, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000269|PubMed:19001261};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19575;
CC         Evidence={ECO:0000269|PubMed:19001261};
CC   -!- SIMILARITY: Belongs to the polyphosphate kinase 2 (PPK2) family. Class
CC       I subfamily. {ECO:0000305}.
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DR   EMBL; AE004091; AAG05816.1; -; Genomic_DNA.
DR   PIR; G83341; G83341.
DR   RefSeq; NP_251118.1; NC_002516.2.
DR   RefSeq; WP_003089666.1; NZ_QZGE01000027.1.
DR   AlphaFoldDB; Q9I154; -.
DR   SMR; Q9I154; -.
DR   STRING; 287.DR97_6005; -.
DR   PaxDb; Q9I154; -.
DR   EnsemblBacteria; AAG05816; AAG05816; PA2428.
DR   GeneID; 882843; -.
DR   KEGG; pae:PA2428; -.
DR   PATRIC; fig|208964.12.peg.2538; -.
DR   PseudoCAP; PA2428; -.
DR   HOGENOM; CLU_048699_3_0_6; -.
DR   InParanoid; Q9I154; -.
DR   OMA; ESTQWYY; -.
DR   PhylomeDB; Q9I154; -.
DR   BioCyc; PAER208964:G1FZ6-2465-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0008976; F:polyphosphate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016898; Polyphosphate_phosphotransfera.
DR   InterPro; IPR022488; PPK2-related.
DR   InterPro; IPR022486; PPK2_PA0141.
DR   Pfam; PF03976; PPK2; 1.
DR   PIRSF; PIRSF028756; PPK2_prd; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03707; PPK2_P_aer; 1.
PE   1: Evidence at protein level;
KW   ATP synthesis; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..304
FT                   /note="ADP-polyphosphate phosphotransferase"
FT                   /id="PRO_0000442588"
SQ   SEQUENCE   304 AA;  36196 MW;  8D07A4441208CAF9 CRC64;
     MDSYGDTSGR IGRDWLDRHD EELEQELLDD ELNLDELFGP EQEDAPGELS RRRYFRELFR
     LQRELVKLQN WVVHTGHKVV ILFEGRDAAG KGGVIKRITQ RLNPRVCRVA ALPAPNDREQ
     TQWYFQRYVS HLPAGGEIVL FDRSWYNRAG VERVMGFCND EQYEEFFRSV PEFEKMLARS
     GIQLLKYWFS ISDAEQHLRF LSRIHDPLKQ WKLSPMDLES RRRWEAYTKA KETMLERTHI
     PEAPWWVVQA DDKKRARLNC IHHLLQQMPY REVPQPPVHL PERLRHADYV RHPTPGEIIV
     PEVY