ID   PK21_AGRFC              Reviewed;         293 AA.
AC   A9CKA8;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=ADP-polyphosphate phosphotransferase {ECO:0000305};
DE            EC=2.7.4.- {ECO:0000269|PubMed:19001261};
DE   AltName: Full=Polyphosphate kinase PPK2 {ECO:0000305};
GN   OrderedLocusNames=Atu0418 {ECO:0000312|EMBL:AAK86232.1};
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
RN   [3]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=19001261; DOI=10.1073/pnas.0807563105;
RA   Nocek B., Kochinyan S., Proudfoot M., Brown G., Evdokimova E., Osipiuk J.,
RA   Edwards A.M., Savchenko A., Joachimiak A., Yakunin A.F.;
RT   "Polyphosphate-dependent synthesis of ATP and ADP by the family-2
RT   polyphosphate kinases in bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:17730-17735(2008).
CC   -!- FUNCTION: Uses inorganic polyphosphate (polyP) as a donor to convert
CC       ADP to ATP. {ECO:0000269|PubMed:19001261}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[phosphate](n) + ATP = [phosphate](n+1) + ADP;
CC         Xref=Rhea:RHEA:19573, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280,
CC         ChEBI:CHEBI:16838, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000269|PubMed:19001261};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19575;
CC         Evidence={ECO:0000269|PubMed:19001261};
CC   -!- SIMILARITY: Belongs to the polyphosphate kinase 2 (PPK2) family. Class
CC       I subfamily. {ECO:0000305}.
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DR   EMBL; AE007869; AAK86232.1; -; Genomic_DNA.
DR   PIR; AH2627; AH2627.
DR   PIR; G97409; G97409.
DR   RefSeq; NP_353447.1; NC_003062.2.
DR   RefSeq; WP_006310670.1; NC_003062.2.
DR   AlphaFoldDB; A9CKA8; -.
DR   SMR; A9CKA8; -.
DR   STRING; 176299.Atu0418; -.
DR   EnsemblBacteria; AAK86232; AAK86232; Atu0418.
DR   KEGG; atu:Atu0418; -.
DR   PATRIC; fig|176299.10.peg.408; -.
DR   eggNOG; COG2326; Bacteria.
DR   HOGENOM; CLU_048699_3_1_5; -.
DR   OMA; TKLWFSV; -.
DR   PhylomeDB; A9CKA8; -.
DR   BioCyc; AGRO:ATU0418-MON; -.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0008976; F:polyphosphate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016898; Polyphosphate_phosphotransfera.
DR   InterPro; IPR022488; PPK2-related.
DR   InterPro; IPR022486; PPK2_PA0141.
DR   Pfam; PF03976; PPK2; 1.
DR   PIRSF; PIRSF028756; PPK2_prd; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03707; PPK2_P_aer; 1.
PE   1: Evidence at protein level;
KW   ATP synthesis; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..293
FT                   /note="ADP-polyphosphate phosphotransferase"
FT                   /id="PRO_0000442582"
SQ   SEQUENCE   293 AA;  34226 MW;  AA95DCD701D34E13 CRC64;
     MGEEKKKRTV EITIGGKLRS FDIDDPVLPD WVEEKKLSAG NFPYDKKMKR EDYDATLEAL
     QVELVKVQFW LQATGKRVMA VFEGRDAAGK GGAIFATHAY LNPRYARVVA LTKPTETERG
     QWYFQRYISH FPTAGEFVLF DRSWYNRAGV EPVMGFCTPD EHKRFLKETP RLEKMLVHDD
     IHLFKFWLDI GRETQIERFH DRRQSPLKCW KLSDMDIAAL TKWDDYTQKR DEMLEKTHTD
     AAPWTVVRAN DKRRARVNLI RHILLALDYE GKDRQAIGEI DDKILGSGPD FLK