PK2L2_MOUSE
ID PK2L2_MOUSE Reviewed; 621 AA.
AC Q9JLG4; B2RS50;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Polycystic kidney disease 2-like 2 protein;
DE AltName: Full=Polycystin-2L2;
DE AltName: Full=Polycystin-L2;
GN Name=Pkd2l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=10756092; DOI=10.1006/geno.2000.6131;
RA Guo L., Schreiber T.H., Weremowicz S., Morton C.C., Lee C., Zhou J.;
RT "Identification and characterization of a novel polycystin family member,
RT polycystin-L2, in mouse and human: sequence, expression, alternative
RT splicing, and chromosomal localization.";
RL Genomics 64:241-251(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a subunit of a cation channel and play a role
CC in fertilization.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed only in testis and heart.
CC -!- SIMILARITY: Belongs to the polycystin family. {ECO:0000305}.
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DR EMBL; AF182033; AAF65621.1; -; mRNA.
DR EMBL; BC138717; AAI38718.1; -; mRNA.
DR CCDS; CCDS29127.1; -.
DR RefSeq; NP_001156476.1; NM_001163004.1.
DR RefSeq; NP_058623.2; NM_016927.3.
DR RefSeq; XP_017173434.1; XM_017317945.1.
DR AlphaFoldDB; Q9JLG4; -.
DR SMR; Q9JLG4; -.
DR STRING; 10090.ENSMUSP00000014647; -.
DR GlyGen; Q9JLG4; 2 sites.
DR PhosphoSitePlus; Q9JLG4; -.
DR PaxDb; Q9JLG4; -.
DR PRIDE; Q9JLG4; -.
DR ProteomicsDB; 288176; -.
DR Antibodypedia; 26539; 102 antibodies from 18 providers.
DR DNASU; 53871; -.
DR Ensembl; ENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
DR Ensembl; ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
DR GeneID; 53871; -.
DR KEGG; mmu:53871; -.
DR UCSC; uc008ekm.2; mouse.
DR CTD; 27039; -.
DR MGI; MGI:1858231; Pkd2l2.
DR VEuPathDB; HostDB:ENSMUSG00000014503; -.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000161122; -.
DR HOGENOM; CLU_012097_1_2_1; -.
DR InParanoid; Q9JLG4; -.
DR OMA; FQNSIFT; -.
DR OrthoDB; 426073at2759; -.
DR PhylomeDB; Q9JLG4; -.
DR TreeFam; TF316484; -.
DR BioGRID-ORCS; 53871; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Pkd2l2; mouse.
DR PRO; PR:Q9JLG4; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9JLG4; protein.
DR Bgee; ENSMUSG00000014503; Expressed in animal zygote and 97 other tissues.
DR Genevisible; Q9JLG4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR Pfam; PF08016; PKD_channel; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..621
FT /note="Polycystic kidney disease 2-like 2 protein"
FT /id="PRO_0000164362"
FT TOPO_DOM 1..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..360
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..468
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 490..621
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT COILED 521..551
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 107
FT /note="N -> T (in Ref. 1; AAF65621)"
FT /evidence="ECO:0000305"
FT CONFLICT 551
FT /note="D -> E (in Ref. 1; AAF65621)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 621 AA; 73683 MW; C542425A2C8A7480 CRC64;
MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV NPHMYYLNKV
MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY WDSWYGNKQL YSVKNSSRIY
YENVLLGIPR VRQLRVRNNT CKVYPAFQSL VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP
SSRTAPWHWG FVGVYRDGGY IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA
NVNLFCIIRL LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE
LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK NTDSYPDFYF
LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL SRCMKDIVGF AIMFFIIFSA
YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANWILGPIY FITFIFFVFF
VLLNMFLAII NDTYSEVKAD YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ
TTDLAQRARR DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV
ELEKELHYVS LKLNQLMRKL H
