ID   PK2_DELRA               Reviewed;           8 AA.
AC   B3EWL5;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-JUN-2021, entry version 9.
DE   RecName: Full=HUG-Pyrokinin {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
DE            Short=HUG-PK {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
OS   Delia radicum (Cabbage root fly) (Anthomyia brassicae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Anthomyiidae; Anthomyiinae; Delia.
OX   NCBI_TaxID=30064;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT
RP   LEU-8.
RC   TISSUE=Abdominal ganglion {ECO:0000269|PubMed:20869420},
RC   Brain {ECO:0000269|PubMed:20869420},
RC   Corpora allata {ECO:0000269|PubMed:20869420}, and
RC   Corpora cardiaca {ECO:0000269|PubMed:20869420};
RX   PubMed=20869420; DOI=10.1016/j.peptides.2010.08.028;
RA   Audsley N., Matthews H.J., Down R.E., Weaver R.J.;
RT   "Neuropeptides associated with the central nervous system of the cabbage
RT   root fly, Delia radicum (L).";
RL   Peptides 32:434-440(2011).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-8.
RC   TISSUE=CNS {ECO:0000269|PubMed:22848525};
RX   PubMed=22848525; DOI=10.1371/journal.pone.0041543;
RA   Zoephel J., Reiher W., Rexer K.-H., Kahnt J., Wegener C.;
RT   "Peptidomics of the agriculturally damaging larval stage of the cabbage
RT   root fly Delia radicum (Diptera: Anthomyiidae).";
RL   PLoS ONE 7:E41543-E41543(2012).
CC   -!- FUNCTION: Mediates visceral muscle contractile activity (myotropic
CC       activity). {ECO:0000250|UniProtKB:P41489}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P41489}.
CC   -!- TISSUE SPECIFICITY: In larvae, expressed in the brain and ring gland
CC       but not in the midgut or the thoracic perisympathetic organs (tPSO) and
CC       abdominal perisympathetic organs (aPSO) (at protein level). In adults,
CC       expressed in the brain, corpora cardiaca, corpora allata and thoracic-
CC       abdominal ganglion (at protein level). {ECO:0000269|PubMed:20869420,
CC       ECO:0000269|PubMed:22848525}.
CC   -!- DEVELOPMENTAL STAGE: Detected in larvae and adults.
CC       {ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525}.
CC   -!- MASS SPECTROMETRY: Mass=973.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: Mass=973.59; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..8
FT                   /note="HUG-Pyrokinin"
FT                   /evidence="ECO:0000269|PubMed:20869420,
FT                   ECO:0000269|PubMed:22848525"
FT                   /id="PRO_0000419732"
FT   MOD_RES         8
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:20869420,
FT                   ECO:0000269|PubMed:22848525"
SQ   SEQUENCE   8 AA;  974 MW;  C834176339D6C2D5 CRC64;
     SVQFKPRL