ID   A6_VACCW                Reviewed;         371 AA.
AC   P29192; Q80HW0;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Protein A6;
GN   OrderedLocusNames=VACWR125; ORFNames=A6L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1731116; DOI=10.1128/jvi.66.2.971-982.1992;
RA   Ahn B.-Y., Rosel J., Cole N.B., Moss B.;
RT   "Identification and expression of rpo19, a vaccinia virus gene encoding a
RT   19-kilodalton DNA-dependent RNA polymerase subunit.";
RL   J. Virol. 66:971-982(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION IN VIRION MATURATION, AND SUBCELLULAR LOCATION.
RX   PubMed=17108027; DOI=10.1128/jvi.02206-06;
RA   Meng X., Embry A., Sochia D., Xiang Y.;
RT   "Vaccinia virus A6L encodes a virion core protein required for formation of
RT   mature virion.";
RL   J. Virol. 81:1433-1443(2007).
CC   -!- FUNCTION: Plays an essential role in immature virion (IV) to mature
CC       virion (MV) transition. {ECO:0000269|PubMed:17108027}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:17108027}.
CC       Note=Localizes to the virion core.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A6 family. {ECO:0000305}.
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DR   EMBL; M76473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY243312; AAO89404.1; -; Genomic_DNA.
DR   PIR; C41806; QQVZA7.
DR   SMR; P29192; -.
DR   DIP; DIP-2189N; -.
DR   IntAct; P29192; 1.
DR   MINT; P29192; -.
DR   Proteomes; UP000000344; Genome.
DR   InterPro; IPR007008; Poxvirus_A6.
DR   Pfam; PF04924; Pox_A6; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Virion.
FT   CHAIN           1..371
FT                   /note="Protein A6"
FT                   /id="PRO_0000099222"
FT   CONFLICT        75
FT                   /note="L -> S (in Ref. 2; AAO89404)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="D -> VY (in Ref. 2; AAO89404)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93..95
FT                   /note="DVE -> YVK (in Ref. 2; AAO89404)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        318
FT                   /note="E -> K (in Ref. 2; AAO89404)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   371 AA;  43007 MW;  013A21BD94612AC6 CRC64;
     MDKLRVLYDE FVTISKDNLE RETGLSASDV DMDFDLNIFM TLVPVLEKKV CAITPTIEDD
     KIVTMMKYCS YQSFLFWFLK SGAVVKSDNK LDDVEKEKFV ATFRDMLLNV QTLISLNSMY
     TRLRQDTEDI VSDSKKIMEI VSHLRASTTE NAAYQVLQQN NSFIISTLNK ILSDENYLLK
     IIAVFDSKLI SEKETLNEYK QLYTISSESL VYGIRCVSNL DISSVQLSNN KYVLFVKKML
     PKIILFQNND INAQQFANVI SKIYTLIYRQ LTSNVDVGCL LTDTIESAKT KISVEKIKQT
     GINNVQSLIK FISDNKKEYK TIISEEYLSK EDRIITILQD IVNEHDIKYD NKLLNMRDLI
     VTFRERYSYK F