PK81F_PSEFD
ID PK81F_PSEFD Reviewed; 572 AA.
AC M2YMU2;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=MFS-type transporter MYCFIDRAFT_190113 {ECO:0000303|PubMed:30735556};
DE AltName: Full=PKS8-1 gene cluster protein MYCFIDRAFT_190113 {ECO:0000303|PubMed:30735556};
GN ORFNames=MYCFIDRAFT_190113;
OS Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease
OS fungus) (Mycosphaerella fijiensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=383855;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIRAD86;
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=27388157; DOI=10.1371/journal.pone.0158471;
RA Noar R.D., Daub M.E.;
RT "Bioinformatics prediction of polyketide synthase gene clusters from
RT Mycosphaerella fijiensis.";
RL PLoS ONE 11:e0158471-e0158471(2016).
RN [3]
RP FUNCTION.
RX PubMed=30735556; DOI=10.1371/journal.pone.0212229;
RA Noar R.D., Thomas E., Daub M.E.;
RT "A novel polyketide synthase gene cluster in the plant pathogenic fungus
RT Pseudocercospora fijiensis.";
RL PLoS ONE 14:e0212229-e0212229(2019).
CC -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC the biosynthesis of an emodin derivative that may be involved in black
CC Sigatoka disease of banana. {ECO:0000269|PubMed:27388157,
CC ECO:0000269|PubMed:30735556}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; KB446562; EME79060.1; -; Genomic_DNA.
DR RefSeq; XP_007929884.1; XM_007931693.1.
DR AlphaFoldDB; M2YMU2; -.
DR SMR; M2YMU2; -.
DR STRING; 83344.XP_007929884.1; -.
DR EnsemblFungi; EME79060; EME79060; MYCFIDRAFT_190113.
DR GeneID; 19335128; -.
DR KEGG; pfj:MYCFIDRAFT_190113; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_22_1_1; -.
DR OrthoDB; 627633at2759; -.
DR Proteomes; UP000016932; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..572
FT /note="MFS-type transporter MYCFIDRAFT_190113"
FT /id="PRO_0000451123"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 539..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 61559 MW; 2562EE8417FD1160 CRC64;
MEFTLQQDKV RALDDDMLVV KSESGGAGLD RGDDESQYPH GLKLAVLMTC VFIGMFLVAL
DKLIISTATP AITNEFHAYS DVGWYGTAYL LTNCATILLF GKLYTFLDVK ATFLSAVLLF
EVGSAVCGAA PNSIAFIVGR AIAGLGAGGI QEGVLVIIVC AIPLSKRPAY QGLFGAVYGV
SSVIGPLLGG AFTTHVSWRW CFYINLPFGG LVALAVFFLL KVPGGGAMKS SWKHKVKELN
IEGLVALLPG VISLCLALQW GGFTYSWSNW RIILCLTLGL VLLIAFIFIQ VWRPKTATVP
PHIFCQRSIF TGFWVSALLG AHQTIIIYFL PIWFQAIKGD SAVQSGIHLL PFVIAIVVSS
ILTGVGTTKT GYYTPFLIIG TVTAAIGAGL FLLLQPHTTT GQWIGYQIVY GFGLGGCYQA
PNVAAQTVLS KDEAPVGTAL ILFATTLFGA IFVSVGQNVL DQQLATKLAG LAGFDITPQQ
INTAGVTGLF QMVPQGLHNA VLYAYNSALR RTFLVGLILA CLTILGSLGM EWRSVKKEQQ
KQQEKAMENE QEEAAKTQKH KYALDTDENF GV
