ID   PKG3_ADE07              Reviewed;          27 AA.
AC   P05663;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   02-JUN-2021, entry version 59.
DE   RecName: Full=Packaging protein 3;
DE   AltName: Full=L1-52/55 kDa protein;
DE   AltName: Full=Packaging protein 52K;
DE   Flags: Fragment;
GN   ORFNames=L1;
OS   Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=10519;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Gomen;
RX   PubMed=6301944; DOI=10.1016/0378-1119(83)90156-7;
RA   Engler J.A., Hoppe M.S., van Bree M.P.;
RT   "The nucleotide sequence of the genes encoded in early region 2b of human
RT   adenovirus type 7.";
RL   Gene 21:145-159(1983).
CC   -!- FUNCTION: Involved in viral genome packaging through its interaction
CC       with packaging proteins 1 and 2. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the genome packaging complex composed of packaging
CC       proteins 1, 2 and 3; this complex specifically binds to the packaging
CC       sequence on the left end of viral genomic DNA and performs packaging of
CC       the viral genome. Interacts with hexon-linking protein IIIa; this
CC       interaction is required to promote correct genome packaging.
CC       {ECO:0000250|UniProtKB:P04496}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P03262}.
CC       Note=Nuclear protein present in empty capsids and assembly
CC       intermediates. {ECO:0000250|UniProtKB:P03262}.
CC   -!- INDUCTION: Expressed in the early phase and late phase of the viral
CC       replicative cycle.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae packaging protein 3 family.
CC       {ECO:0000305}.
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DR   EMBL; X03000; CAA26776.1; -; Genomic_DNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Late protein; Viral genome packaging;
KW   Viral release from host cell.
FT   CHAIN           1..>27
FT                   /note="Packaging protein 3"
FT                   /id="PRO_0000221867"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         27
SQ   SEQUENCE   27 AA;  3108 MW;  E5A8288B117BB533 CRC64;
     MHPVLRQMRP QQQAPSQQQP QKALLAP