ID   PKG3_ADECR              Reviewed;         389 AA.
AC   P68973; Q65948; Q96683;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   23-FEB-2022, entry version 44.
DE   RecName: Full=Packaging protein 3 {ECO:0000255|HAMAP-Rule:MF_04058};
DE   AltName: Full=L1-52/55 kDa protein {ECO:0000255|HAMAP-Rule:MF_04058};
DE   AltName: Full=Packaging protein 52K {ECO:0000255|HAMAP-Rule:MF_04058};
GN   Name=L1 {ECO:0000255|HAMAP-Rule:MF_04058};
OS   Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1
OS   (strain RI261)).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Canine mastadenovirus A.
OX   NCBI_TaxID=69151;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9129661; DOI=10.1099/0022-1317-78-4-873;
RA   Morrison M.D., Onions D.E., Nicolson L.;
RT   "Complete DNA sequence of canine adenovirus type 1.";
RL   J. Gen. Virol. 78:873-878(1997).
CC   -!- FUNCTION: Involved in viral genome packaging through its interaction
CC       with packaging proteins 1 and 2. After proteolytic cleavage by
CC       adenovirus protease, L1 52/55k protein is removed from the capsid
CC       during viral maturation. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SUBUNIT: Part of the genome packaging complex composed of packaging
CC       proteins 1, 2 and 3; this complex specifically binds to the packaging
CC       sequence on the left end of viral genomic DNA and performs packaging of
CC       the viral genome. Interacts with hexon-linking protein IIIa; this
CC       interaction is required to promote correct genome packaging.
CC       {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04058}.
CC       Note=Nuclear protein present in empty capsids and assembly
CC       intermediates. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- INDUCTION: Expressed in the early phase and late phase of the viral
CC       replicative cycle. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- PTM: Cleaved at different sites by the viral protease during virion
CC       maturation. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SIMILARITY: Belongs to the adenoviridae packaging protein 3 family.
CC       {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA69059.1; Type=Erroneous initiation;
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DR   EMBL; Y07760; CAA69059.1; ALT_INIT; Genomic_DNA.
DR   SMR; P68973; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019073; P:viral DNA genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04058; ADV_PKG3; 1.
DR   InterPro; IPR037536; ADV_PKG3.
DR   InterPro; IPR004292; L1-like.
DR   Pfam; PF03052; Adeno_52K; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Late protein; Phosphoprotein; Viral genome packaging;
KW   Viral release from host cell.
FT   CHAIN           1..389
FT                   /note="Packaging protein 3"
FT                   /id="PRO_0000221870"
FT   REGION          1..131
FT                   /note="Interaction with packaging protein 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04058"
FT   REGION          350..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  43901 MW;  C1AEDE19F279261D CRC64;
     MHPVLRQMKP LPASVVKLEA ESEGLARLQG GAAPEVHPRV QMKQEAAEAY IPASNVFRDN
     EGEEAEGLRH LKYESGRMLR KDHPSKRVLD ERDFEKSPEN GISAAEAHLK SADLVTAYEH
     TVKAEVNFQT TFNNNVRTLI AREEVVIGLM HLWDFVEAFL ENPVSKALTA QLFLIVQHCR
     DEGVLRESLL NIAEPESRWL VDLLNLLQTI VVQERSLAVG EKVAAINYSV ITLSKHYARK
     IFNSVFVPID KEAKINTFYM RTVVQILVLS DDLGMYRNER IERAVSGARQ RELNDRELMY
     RLREALTSNG LSEIEGGEDS ARVRSKENWG AGAGVGAASA RYPHLLDYEE KENPDGSVSF
     QQHERGTQSH ENGGHAEPAY SRRQLGRFY