ID   PKG3_ADES1              Reviewed;         322 AA.
AC   A9CB88;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   02-JUN-2021, entry version 41.
DE   RecName: Full=Packaging protein 3 {ECO:0000255|HAMAP-Rule:MF_04058};
DE   AltName: Full=L1-52/55 kDa protein {ECO:0000255|HAMAP-Rule:MF_04058};
DE   AltName: Full=Packaging protein 52K {ECO:0000255|HAMAP-Rule:MF_04058};
GN   Name=L1 {ECO:0000255|HAMAP-Rule:MF_04058};
OS   Snake adenovirus serotype 1 (SnAdV-1).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Atadenovirus.
OX   NCBI_TaxID=189830;
OH   NCBI_TaxID=94885; Pantherophis guttatus (Corn snake) (Elaphe guttata).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12237421; DOI=10.1099/0022-1317-83-10-2403;
RA   Farkas S.L., Benko M., Elo P.T., Ursu K., Dan A., Ahne W., Harrach B.;
RT   "Genetic analysis of an adenovirus isolated from corn snake (Elaphe
RT   guttata) implies common origin with the members of the proposed new genus
RT   Atadenovirus.";
RL   J. Gen. Virol. 83:2403-2410(2002).
CC   -!- FUNCTION: Involved in viral genome packaging through its interaction
CC       with packaging proteins 1 and 2. After proteolytic cleavage by
CC       adenovirus protease, L1 52/55k protein is removed from the capsid
CC       during viral maturation. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SUBUNIT: Part of the genome packaging complex composed of packaging
CC       proteins 1, 2 and 3; this complex specifically binds to the packaging
CC       sequence on the left end of viral genomic DNA and performs packaging of
CC       the viral genome. Interacts with hexon-linking protein IIIa; this
CC       interaction is required to promote correct genome packaging.
CC       {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04058}.
CC       Note=Nuclear protein present in empty capsids and assembly
CC       intermediates. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- INDUCTION: Expressed in the early phase and late phase of the viral
CC       replicative cycle. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- PTM: Cleaved at different sites by the viral protease during virion
CC       maturation. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell. {ECO:0000255|HAMAP-Rule:MF_04058}.
CC   -!- SIMILARITY: Belongs to the adenoviridae packaging protein 3 family.
CC       {ECO:0000255|HAMAP-Rule:MF_04058}.
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DR   EMBL; DQ106414; ABA47238.1; -; Genomic_DNA.
DR   RefSeq; YP_001552249.1; NC_009989.1.
DR   GeneID; 10973891; -.
DR   KEGG; vg:10973891; -.
DR   Proteomes; UP000136605; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019073; P:viral DNA genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04058; ADV_PKG3; 1.
DR   InterPro; IPR037536; ADV_PKG3.
DR   InterPro; IPR004292; L1-like.
DR   Pfam; PF03052; Adeno_52K; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Late protein; Phosphoprotein; Reference proteome;
KW   Viral genome packaging; Viral release from host cell.
FT   CHAIN           1..322
FT                   /note="Packaging protein 3"
FT                   /id="PRO_0000425921"
FT   REGION          1..127
FT                   /note="Interaction with packaging protein 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04058"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  36790 MW;  5125CEACC3A071D1 CRC64;
     MHPILKNIRS QPDQGRAEEH NPELHCGIAG TGGLEEQLRS KQREDRFHKA CPPAVDLNRD
     DTQLYGEGER DLRLKSSACV QLDRTPVTPE DFVPDDMGSR AIRQMEAAKL VRNGQHTRDV
     ERWQHDTYCS HLTQLLVRPL TSLGVMYLAD FLNTFVELPP NHTLTMQLVT IINHTSEPTL
     RRLLKDIGEK DAEGHLKNEW LLQLLSIIEM IFKDEPSERA RLTALLTVTN EVALNFSKKA
     SGGNYPTTDR LSKTLTYFRR MIVALLALAE SLGCYTNNYC ARKPEKRCRT QVEPSDESYM
     FSLKGALEAP ESDEEEEEWI RD