ID   PKHA2_BOVIN             Reviewed;         425 AA.
AC   Q3ZBA3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Pleckstrin homology domain-containing family A member 2;
DE            Short=PH domain-containing family A member 2;
GN   Name=PLEKHA2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to phosphatidylinositol 3,4-diphosphate
CC       (PtdIns3,4P2), but not to other phosphoinositides. May recruit other
CC       proteins to the plasma membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds MPDZ and PTPN13. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Locates to the plasma membrane after treatments
CC       that stimulate the production of PtdIns3,4P2. {ECO:0000250}.
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DR   EMBL; BC103474; AAI03475.1; -; mRNA.
DR   RefSeq; NP_001030460.1; NM_001035383.1.
DR   AlphaFoldDB; Q3ZBA3; -.
DR   SMR; Q3ZBA3; -.
DR   STRING; 9913.ENSBTAP00000031440; -.
DR   PaxDb; Q3ZBA3; -.
DR   PRIDE; Q3ZBA3; -.
DR   Ensembl; ENSBTAT00000078362; ENSBTAP00000068621; ENSBTAG00000003509.
DR   GeneID; 530879; -.
DR   KEGG; bta:530879; -.
DR   CTD; 59339; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003509; -.
DR   VGNC; VGNC:33004; PLEKHA2.
DR   eggNOG; ENOG502QV0M; Eukaryota.
DR   GeneTree; ENSGT00940000158064; -.
DR   HOGENOM; CLU_055135_1_0_1; -.
DR   InParanoid; Q3ZBA3; -.
DR   OMA; QANHLLW; -.
DR   OrthoDB; 1513983at2759; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000003509; Expressed in neutrophil and 102 other tissues.
DR   ExpressionAtlas; Q3ZBA3; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0030165; F:PDZ domain binding; IBA:GO_Central.
DR   GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00169; PH; 2.
DR   SMART; SM00233; PH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Isopeptide bond; Lipid-binding; Membrane;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation.
FT   CHAIN           1..425
FT                   /note="Pleckstrin homology domain-containing family A
FT                   member 2"
FT                   /id="PRO_0000053875"
FT   DOMAIN          7..113
FT                   /note="PH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          198..298
FT                   /note="PH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          374..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         184
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB19"
FT   MOD_RES         314
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB19"
FT   MOD_RES         349
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB19"
FT   CROSSLNK        141
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB19"
SQ   SEQUENCE   425 AA;  47432 MW;  B54FAE4CC8CAEFA3 CRC64;
     MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA IGAGAVGSLQ
     LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD LKDWVEALNQ ASKITVPKAG
     NLPLTTEVLK SLATPLALEK KPQVAYKTEI IGGVVVHTPI NQNGGDGQEV GEPGSHAILR
     RSQSYIPTTG CRGPTGPPLI KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR
     TIFLKDVLKT HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL
     KCHPREMSFS RSISLTRPGS SSLSGGPNSI LCRGRAPGEE RKTLCKAPSL ASSWQPWTPV
     PQAGEKLLPT EETAEDSLFT PRLGESSTSA VLPSSRIRHR SEPQHPKEKP FVFNLDDENI
     RTSDV