PKHA4_RAT
ID PKHA4_RAT Reviewed; 779 AA.
AC P60669;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Pleckstrin homology domain-containing family A member 4;
DE Short=PH domain-containing family A member 4;
DE AltName: Full=Phosphoinositol 3-phosphate-binding protein 1;
DE Short=PEPP-1;
GN Name=Plekha4; Synonyms=Pepp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds specifically to phosphatidylinositol 3-phosphate
CC (PtdIns3P), but not to other phosphoinositides. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}.
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DR EMBL; BC061738; AAH61738.1; -; mRNA.
DR RefSeq; NP_954532.1; NM_199101.1.
DR AlphaFoldDB; P60669; -.
DR SMR; P60669; -.
DR STRING; 10116.ENSRNOP00000028423; -.
DR iPTMnet; P60669; -.
DR PhosphoSitePlus; P60669; -.
DR PaxDb; P60669; -.
DR PRIDE; P60669; -.
DR Ensembl; ENSRNOT00000028423; ENSRNOP00000028423; ENSRNOG00000020942.
DR GeneID; 308584; -.
DR KEGG; rno:308584; -.
DR UCSC; RGD:735133; rat.
DR CTD; 57664; -.
DR RGD; 735133; Plekha4.
DR eggNOG; ENOG502RI1J; Eukaryota.
DR GeneTree; ENSGT00940000161121; -.
DR HOGENOM; CLU_020168_0_0_1; -.
DR InParanoid; P60669; -.
DR OMA; WGPAWDA; -.
DR OrthoDB; 71844at2759; -.
DR PhylomeDB; P60669; -.
DR Reactome; R-RNO-1660499; Synthesis of PIPs at the plasma membrane.
DR PRO; PR:P60669; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000020942; Expressed in esophagus and 19 other tissues.
DR Genevisible; P60669; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISO:RGD.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; ISO:RGD.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISO:RGD.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISO:RGD.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISO:RGD.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:2000096; P:positive regulation of Wnt signaling pathway, planar cell polarity pathway; ISO:RGD.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lipid-binding; Membrane; Phosphoprotein; Reference proteome.
FT CHAIN 1..779
FT /note="Pleckstrin homology domain-containing family A
FT member 4"
FT /id="PRO_0000053882"
FT DOMAIN 54..153
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 152..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H4M7"
FT MOD_RES 562
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H4M7"
SQ SEQUENCE 779 AA; 85642 MW; 091A4BC54096447C CRC64;
MEQGRPRSSL SLTSSASTVS SLSSLSAKKP TRVVHKVHAF GKRNNALRRD PNLPVHIRGW
LHKQDSSGLR LWKRRWFVLS GHCLFYYKDS REESVLGSVL LPSYSVRPDG PGAPRGRRFT
FTAEHPGMRT YVLAADTLED LRGWLRALGK ASRAEGEDCG LPRSPARPRP GEGPGGPGGP
PEVNRREEGR TSESPEVAPL SRGPGRHEMH APGSSADLQP DTWSRRTRSP EPFSPLSRPP
SPLSLPRPRS APVRRPPLSA GDISFPARPH TPLSRIDVRP PLDWGPQRQT LSRPPIPRRG
PFSEAGGGRP PRSPQLRTPE HRTQSTQVSS GSSTYLQLPP RPPGTQASMI LLPGPPVDST
LHQSLETDTL LTKLCGQDRL LRQLQEDLDK RQEEKEQLEA ALELTRQQLG QATREAAASG
KAWGRQRLLQ DRLVNVRAAL CHLTQERERV WDTYSGLEQD LGTLRETLEY LLHLGSPQDR
ASAQQQLWMV EDTLAGLGGP QKQPPHTEPK SPSPAPQREE SSERESLSES LELSSPQSPE
VDWGQPPGGD RALSSSQSGV GSPRVSRASS PECRQQSSPL LRTKAPLARP RMSAQEQLER
MRRNQACGLS LPRPTSPRLL TLGRTLSPVP RQPDMEQRPI VGAAKWLRSS GSWSSPRHST
TYSPVSGGHR ERVLSLSQAL ATEASQWHRL MTASPERNLD TRGDCLQPSP QPPSEELPQV
TSSPTSHKAN SATTGFSCQG SGRGLAPWEP RWDPGKAPPA LAQEEGAWPL RVTLLQSSF
