PKHA7_DANRE
ID PKHA7_DANRE Reviewed; 1197 AA.
AC B6RSP1; A3KQE1;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Pleckstrin homology domain-containing family A member 7;
DE Short=PH domain-containing family A member 7;
DE AltName: Full=Heart adapter protein 1;
GN Name=plekha7; Synonyms=hadp1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AB;
RA Wythe J.D., Urness L.D., Jones C.A., Jurynec M., Grunwald D.J.,
RA MacRae C.A., Li D.Y.;
RT "HADP1, a novel pleckstrin homology domain protein, is required for cardiac
RT contractility in zebrafish.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for zonula adherens biogenesis and maintenance.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM47001.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EU380770; ACB38002.1; -; mRNA.
DR EMBL; BX640463; CAM47001.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CR936464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR391988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001129715.1; NM_001136243.1.
DR AlphaFoldDB; B6RSP1; -.
DR SMR; B6RSP1; -.
DR STRING; 7955.ENSDARP00000080529; -.
DR PaxDb; B6RSP1; -.
DR PRIDE; B6RSP1; -.
DR GeneID; 571486; -.
DR KEGG; dre:571486; -.
DR CTD; 571486; -.
DR ZFIN; ZDB-GENE-050419-75; plekha7a.
DR eggNOG; KOG0940; Eukaryota.
DR InParanoid; B6RSP1; -.
DR OrthoDB; 71844at2759; -.
DR PhylomeDB; B6RSP1; -.
DR Reactome; R-DRE-1660499; Synthesis of PIPs at the plasma membrane.
DR PRO; PR:B6RSP1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005915; C:zonula adherens; ISS:UniProtKB.
DR GO; GO:0070097; F:delta-catenin binding; ISS:UniProtKB.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IMP:ZFIN.
DR GO; GO:0090136; P:epithelial cell-cell adhesion; ISS:UniProtKB.
DR GO; GO:0008016; P:regulation of heart contraction; IMP:ZFIN.
DR GO; GO:0045218; P:zonula adherens maintenance; ISS:UniProtKB.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; SSF51045; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Cell junction; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome;
KW Repeat.
FT CHAIN 1..1197
FT /note="Pleckstrin homology domain-containing family A
FT member 7"
FT /id="PRO_0000395802"
FT DOMAIN 8..41
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 53..86
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 158..257
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 98..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 678..799
FT /evidence="ECO:0000255"
FT COILED 1016..1044
FT /evidence="ECO:0000255"
FT COMPBIAS 105..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..562
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..897
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 514
FT /note="S -> F (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 535
FT /note="S -> P (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 624
FT /note="H -> R (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 638
FT /note="D -> G (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 756
FT /note="R -> G (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 791
FT /note="I -> M (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 853
FT /note="P -> S (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 1072
FT /note="Y -> H (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 1090
FT /note="L -> S (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
FT CONFLICT 1126
FT /note="L -> P (in Ref. 1; ACB38002)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1197 AA; 135554 MW; C808D5D9140C035F CRC64;
MAAPLRRDTL PDNGSYGVCR DGRVFFIDDE ARATTWLHPR TGQPVNSGHM IRSDLPSGWE
EGFTKEGASF FIDHNQRTTT FIHPVTGQIS TENSDFRLQD QPGGRMLKQP SSTISEASTT
VTTSTVDSTS GSKGSRSSGR VHSFGKRDHA IKRNPSVPVV VRGWLYKQDS SGMRLWKRKW
FVLADFCLFY YKDSREESVL GSIPLPSYTI APVGPEDHIS RKYAFKAEHT GMRTYYFSAD
TQEDMNGWVR AMNQAALMQT HTVKRDECGH PDHVNVSEKL KKQAVPQTNH INSYVIPKPE
VIQSDGLPED KREGFVGEVE IQVTPREMEQ ARGKSPASRV VEVEVLAPGS TPPSRVASRA
PSRAVSTPPV VQRNGTPIEQ NGMPGCQRGA TPSAQTPVQV QRRSTLEQVE NWVKVQKEER
HGLVSTESTV PRRTPPIHPK YGTMDKYQSL PKTSRQSPPA PHHQLPSEYK YSHDRLNHFQ
KIHGHTKRPT THDNTVWQLF EWQQRQQFRH GSPSAPVYTP APDYSTAVSS TRNNSDVSRS
VSVPPTLADI PPPGPPGARL MSPRRPHTPA ERVTVRPLED RPIVEVPPSN SPHRLRSYKS
ATIERRSMPP SAYITHTVSA PSLHGKTADD TYMHLKKDLE YLDLKVSGTE ALKGRPAKPV
KVAESDVDVT LSRLCEQDKI LQELEFRLSG LKDDKDKLES VLDVSHQQME QYKDQPSHTD
KIAYQQRLLQ EDLVHIRADI SRVSTEMERA WDDYSRMEQS VEQLRDVLQT QMTLCTSPQE
KNQLKRELWR IEDVMTGLSS TKETFKITVD SVKNPERKLV PSVIESTVPS RCMTPSAAEV
RSPQRSLTSS PLPLPLDNED LRNRHPVPNW EEDDAPPRPP LPLLYDEDTP PVVPPLPKET
SVIRHTSVRG LKRQSDERKR DRESSYSNGD YRLELRSYLS EPELPVSAHG ADHVDPGYLT
LQRRGLSGSS SRINQYGVAS CSLRRDLELS TMERPKSALE RLCSGEPQLE QQSQPQRVRM
SVEEQLERMK RHQRALVRER KRNLSQGERH HSRASTRPVN SDPGSALFVE PYRPASDEWL
TVRARPVMEL ELEPLDFEFD ITRELSTPQK VWIPQRLIDD ESDEDLSPEE KETRSRTVAK
IKTLLSKSSM RSSEQMDFSD LDLALQQQER IMSVPRALAT EASIKRRQVT AKAMSEG
