ID   PKHB1_RAT               Reviewed;         223 AA.
AC   Q9WU68;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Pleckstrin homology domain-containing family B member 1;
DE            Short=PH domain-containing family B member 1;
DE   AltName: Full=Evectin-1;
GN   Name=Plekhb1; Synonyms=Evt1, Kpl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Schwann cell;
RX   PubMed=10200314; DOI=10.1073/pnas.96.8.4633;
RA   Krappa R., Nguyen A., Burrola P., Deretic D., Lemke G.;
RT   "Evectins: vesicular proteins that carry a pleckstrin homology domain and
RT   localize to post-Golgi membranes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:4633-4638(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Tracheal epithelium;
RX   PubMed=10923244; DOI=10.1080/019021400404537;
RA   Andrews K.L., Potdar P.D., Nettesheim P., Ostrowski L.E.;
RT   "KPL1, which encodes a novel PH domain-containing protein, is induced
RT   during ciliated cell differentiation of rat tracheal epithelial cells.";
RL   Exp. Lung Res. 26:257-271(2000).
CC   -!- SUBUNIT: Homodimer. Interacts (via PH domain) with MYO1C. Interacts
CC       (via PH domain) with MYO7A (By similarity). Binds transducins (By
CC       similarity). {ECO:0000250|UniProtKB:Q9QYE9,
CC       ECO:0000250|UniProtKB:Q9UF11}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10200314}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9QYE9}. Note=Localizes to the apical juxta-
CC       nuclear Golgi region of the cytoplasm (By similarity). Membrane-
CC       associated. Highly expressed in the outer segments of photoreceptor
CC       cells, both in rods and cones (By similarity).
CC       {ECO:0000250|UniProtKB:Q9QYE9, ECO:0000250|UniProtKB:Q9UF11}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in photoreceptor cells,
CC       oligodendrocytes and throughout the myelinated parts of the central
CC       nervous system. Detected in brain, liver, kidney, spleen and trachea.
CC       {ECO:0000269|PubMed:10200314, ECO:0000269|PubMed:10923244}.
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DR   EMBL; AF118562; AAD23762.1; -; mRNA.
DR   EMBL; AF081582; AAF21785.1; -; mRNA.
DR   RefSeq; NP_742030.1; NM_172033.2.
DR   AlphaFoldDB; Q9WU68; -.
DR   SMR; Q9WU68; -.
DR   STRING; 10116.ENSRNOP00000025245; -.
DR   iPTMnet; Q9WU68; -.
DR   PhosphoSitePlus; Q9WU68; -.
DR   PaxDb; Q9WU68; -.
DR   Ensembl; ENSRNOT00000025245; ENSRNOP00000025245; ENSRNOG00000018627.
DR   GeneID; 64471; -.
DR   KEGG; rno:64471; -.
DR   UCSC; RGD:621614; rat.
DR   CTD; 58473; -.
DR   RGD; 621614; Plekhb1.
DR   eggNOG; ENOG502RQ6P; Eukaryota.
DR   GeneTree; ENSGT00390000013989; -.
DR   HOGENOM; CLU_102020_0_0_1; -.
DR   InParanoid; Q9WU68; -.
DR   OMA; HFNVRDV; -.
DR   OrthoDB; 1558185at2759; -.
DR   PhylomeDB; Q9WU68; -.
DR   PRO; PR:Q9WU68; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000018627; Expressed in Ammon's horn and 19 other tissues.
DR   ExpressionAtlas; Q9WU68; baseline and differential.
DR   Genevisible; Q9WU68; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR   GO; GO:0008022; F:protein C-terminus binding; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0045595; P:regulation of cell differentiation; IEP:RGD.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039816; PLEKHB1.
DR   InterPro; IPR039680; PLEKHB1/2.
DR   PANTHER; PTHR14309; PTHR14309; 1.
DR   PANTHER; PTHR14309:SF7; PTHR14309:SF7; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Membrane; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Pleckstrin homology domain-containing family B
FT                   member 1"
FT                   /id="PRO_0000053888"
FT   DOMAIN          2..109
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   223 AA;  25244 MW;  758C985C669BEDC9 CRC64;
     MALVRGGWLW RQSSILRRWK RNWFALWLDG TLGYYHDETA QDEEDRVVIH FNVRDIKVGQ
     ECQDVQPPEG RSRDGLLTVN LREGSRLHLC AETRDDAIAW KTALMEANST PAPAGATVPP
     RSRRVCPKVR CTSLSWKPCK VERRIWVRVY SPYQDYYEVV PPNAHEATYV RSYYGPPYGP
     GVTHVIVRED PCYSSGAPLA MGMLAGAATG AALGSLMWSP CWF