ID   PKHB2_CHICK             Reviewed;         224 AA.
AC   Q5F3S2;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Pleckstrin homology domain-containing family B member 2;
DE            Short=PH domain-containing family B member 2;
DE   AltName: Full=Evectin-2;
GN   Name=PLEKHB2; Synonyms=EVT2; ORFNames=RCJMB04_8b5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in retrograde transport of recycling endosomes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250};
CC       Peripheral membrane protein. Note=Specifically detected in
CC       tubulovesicular structures, and colocalizes with TFNR. {ECO:0000250}.
CC   -!- DOMAIN: The PH domain specifically binds phosphatidylserine, which is
CC       enriched in recycling endosome membranes, it doesn't recognize PIPs.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ851578; CAH65212.1; -; mRNA.
DR   RefSeq; NP_001026473.1; NM_001031302.1.
DR   AlphaFoldDB; Q5F3S2; -.
DR   SMR; Q5F3S2; -.
DR   STRING; 9031.ENSGALP00000040702; -.
DR   PaxDb; Q5F3S2; -.
DR   GeneID; 424758; -.
DR   KEGG; gga:424758; -.
DR   CTD; 55041; -.
DR   VEuPathDB; HostDB:geneid_424758; -.
DR   eggNOG; ENOG502R270; Eukaryota.
DR   InParanoid; Q5F3S2; -.
DR   OrthoDB; 1558185at2759; -.
DR   PhylomeDB; Q5F3S2; -.
DR   PRO; PR:Q5F3S2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039680; PLEKHB1/2.
DR   InterPro; IPR039815; PLEKHB2.
DR   PANTHER; PTHR14309; PTHR14309; 1.
DR   PANTHER; PTHR14309:SF8; PTHR14309:SF8; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Reference proteome.
FT   CHAIN           1..224
FT                   /note="Pleckstrin homology domain-containing family B
FT                   member 2"
FT                   /id="PRO_0000253639"
FT   DOMAIN          2..109
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   BINDING         20
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-L-serine"
FT                   /ligand_id="ChEBI:CHEBI:57262"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  25410 MW;  8A7980ABFDB45C60 CRC64;
     MAFVKSGWLL RQSTILRRWK KNWFDLWSDG RLIFYDDQNR HDIEDKIHMR IHCINLRVGN
     ECRDFQPPEG KQRDCLLQIV CRDGKTVNLC AESADDCLAW KIALQDARTN TGYVGSDVMY
     DETAISSAPP PYTAYATPSP EVYGYGYGQY HGAYPTVGPQ VFYASNGQAY DVPYQYPYHG
     PYGQPPANHV IIRERYRDND GDLALGMLAG AATGMALGSL FWVF