PKHB2_HUMAN
ID PKHB2_HUMAN Reviewed; 222 AA.
AC Q96CS7; B4DF08; B4DZ66; B8ZZN1; Q53FF1; Q53TH7; Q86W37; Q9BV75; Q9NWK1;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Pleckstrin homology domain-containing family B member 2;
DE Short=PH domain-containing family B member 2;
DE AltName: Full=Evectin-2;
GN Name=PLEKHB2; Synonyms=EVT2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
RC TISSUE=Cerebellum, Colon, Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Pancreas, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 1-110, FUNCTION, AND SUBCELLULAR
RP LOCATION.
RX PubMed=21911378; DOI=10.1073/pnas.1109101108;
RA Uchida Y., Hasegawa J., Chinnapen D., Inoue T., Okazaki S., Kato R.,
RA Wakatsuki S., Misaki R., Koike M., Uchiyama Y., Iemura S., Natsume T.,
RA Kuwahara R., Nakagawa T., Nishikawa K., Mukai K., Miyoshi E., Taniguchi N.,
RA Sheff D., Lencer W.I., Taguchi T., Arai H.;
RT "Intracellular phosphatidylserine is essential for retrograde membrane
RT traffic through endosomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:15846-15851(2011).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1-110 IN COMPLEX WITH
RP O-PHOSPHOSERINE, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=22281740; DOI=10.1107/s0907444911051626;
RA Okazaki S., Kato R., Uchida Y., Taguchi T., Arai H., Wakatsuki S.;
RT "Structural basis of the strict phospholipid binding specificity of the
RT pleckstrin homology domain of human evectin-2.";
RL Acta Crystallogr. D 68:117-123(2012).
CC -!- FUNCTION: Involved in retrograde transport of recycling endosomes.
CC {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}.
CC -!- INTERACTION:
CC Q96CS7; O14503: BHLHE40; NbExp=3; IntAct=EBI-373552, EBI-711810;
CC Q96CS7; Q6P1W5: C1orf94; NbExp=6; IntAct=EBI-373552, EBI-946029;
CC Q96CS7; P34810: CD68; NbExp=3; IntAct=EBI-373552, EBI-2826276;
CC Q96CS7; P32320: CDA; NbExp=6; IntAct=EBI-373552, EBI-9250559;
CC Q96CS7; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-373552, EBI-12256978;
CC Q96CS7; Q15038: DAZAP2; NbExp=11; IntAct=EBI-373552, EBI-724310;
CC Q96CS7; Q96GG9: DCUN1D1; NbExp=5; IntAct=EBI-373552, EBI-740086;
CC Q96CS7; P54849: EMP1; NbExp=3; IntAct=EBI-373552, EBI-4319440;
CC Q96CS7; P54852: EMP3; NbExp=3; IntAct=EBI-373552, EBI-3907816;
CC Q96CS7; Q9Y6I3: EPN1; NbExp=3; IntAct=EBI-373552, EBI-713198;
CC Q96CS7; O95208-2: EPN2; NbExp=3; IntAct=EBI-373552, EBI-12135243;
CC Q96CS7; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-373552, EBI-11978259;
CC Q96CS7; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-373552, EBI-11961494;
CC Q96CS7; Q9NZ52-2: GGA3; NbExp=3; IntAct=EBI-373552, EBI-12075758;
CC Q96CS7; P29033: GJB2; NbExp=3; IntAct=EBI-373552, EBI-3905204;
CC Q96CS7; Q9BZE0: GLIS2; NbExp=5; IntAct=EBI-373552, EBI-7251368;
CC Q96CS7; Q9Y5J3: HEY1; NbExp=3; IntAct=EBI-373552, EBI-7231130;
CC Q96CS7; Q9NQ87: HEYL; NbExp=3; IntAct=EBI-373552, EBI-751092;
CC Q96CS7; O14964: HGS; NbExp=3; IntAct=EBI-373552, EBI-740220;
CC Q96CS7; Q71SY5: MED25; NbExp=3; IntAct=EBI-373552, EBI-394558;
CC Q96CS7; Q8N3F0: MTURN; NbExp=5; IntAct=EBI-373552, EBI-11980301;
CC Q96CS7; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-373552, EBI-741158;
CC Q96CS7; Q96DC9: OTUB2; NbExp=3; IntAct=EBI-373552, EBI-746259;
CC Q96CS7; Q86T03: PIP4P1; NbExp=3; IntAct=EBI-373552, EBI-6164623;
CC Q96CS7; P78337: PITX1; NbExp=3; IntAct=EBI-373552, EBI-748265;
CC Q96CS7; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-373552, EBI-1389308;
CC Q96CS7; O75360: PROP1; NbExp=3; IntAct=EBI-373552, EBI-9027467;
CC Q96CS7; Q8TEB9: RHBDD1; NbExp=3; IntAct=EBI-373552, EBI-9916444;
CC Q96CS7; P62979: RPS27A; NbExp=3; IntAct=EBI-373552, EBI-357375;
CC Q96CS7; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-373552, EBI-2854842;
CC Q96CS7; P14678-2: SNRPB; NbExp=3; IntAct=EBI-373552, EBI-372475;
CC Q96CS7; O75886: STAM2; NbExp=6; IntAct=EBI-373552, EBI-373258;
CC Q96CS7; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-373552, EBI-12187159;
CC Q96CS7; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-373552, EBI-529518;
CC Q96CS7; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-373552, EBI-11988865;
CC Q96CS7; P62987: UBA52; NbExp=3; IntAct=EBI-373552, EBI-357304;
CC Q96CS7; Q9BSL1: UBAC1; NbExp=3; IntAct=EBI-373552, EBI-749370;
CC Q96CS7; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-373552, EBI-2514383;
CC Q96CS7; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-373552, EBI-7353612;
CC Q96CS7; P0CG47: UBB; NbExp=3; IntAct=EBI-373552, EBI-413034;
CC Q96CS7; P0CG48: UBC; NbExp=3; IntAct=EBI-373552, EBI-3390054;
CC Q96CS7; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-373552, EBI-947187;
CC Q96CS7; Q9BZV1: UBXN6; NbExp=5; IntAct=EBI-373552, EBI-1993899;
CC Q96CS7; Q5VVQ6: YOD1; NbExp=5; IntAct=EBI-373552, EBI-2510804;
CC Q96CS7; Q8N6M9: ZFAND2A; NbExp=3; IntAct=EBI-373552, EBI-3921109;
CC -!- SUBCELLULAR LOCATION: Recycling endosome membrane
CC {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}; Peripheral
CC membrane protein {ECO:0000269|PubMed:21911378,
CC ECO:0000269|PubMed:22281740}. Note=Specifically detected in
CC tubulovesicular structures, and colocalizes with TFNR.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q96CS7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96CS7-2; Sequence=VSP_009783;
CC Name=3;
CC IsoId=Q96CS7-3; Sequence=VSP_009784;
CC Name=4;
CC IsoId=Q96CS7-4; Sequence=VSP_045163;
CC Name=5;
CC IsoId=Q96CS7-5; Sequence=VSP_045164;
CC Name=6;
CC IsoId=Q96CS7-6; Sequence=VSP_047118;
CC -!- DOMAIN: The PH domain specifically binds phosphatidylserine, which is
CC enriched in recycling endosome membranes, it doesn't recognize PIPs.
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DR EMBL; AK000790; BAA91379.1; -; mRNA.
DR EMBL; AK123710; BAG53942.1; -; mRNA.
DR EMBL; AK293880; BAG57269.1; -; mRNA.
DR EMBL; AK302770; BAG63978.1; -; mRNA.
DR EMBL; AK223338; BAD97058.1; -; mRNA.
DR EMBL; AC073869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC009477; AAX93135.1; -; Genomic_DNA.
DR EMBL; CH471250; EAW51261.1; -; Genomic_DNA.
DR EMBL; CH471250; EAW51263.1; -; Genomic_DNA.
DR EMBL; CH471250; EAW51266.1; -; Genomic_DNA.
DR EMBL; BC001428; AAH01428.1; -; mRNA.
DR EMBL; BC013991; AAH13991.1; -; mRNA.
DR EMBL; BC050695; AAH50695.2; -; mRNA.
DR CCDS; CCDS2166.1; -. [Q96CS7-3]
DR CCDS; CCDS46413.1; -. [Q96CS7-1]
DR CCDS; CCDS58729.1; -. [Q96CS7-5]
DR CCDS; CCDS58730.1; -. [Q96CS7-6]
DR CCDS; CCDS58731.1; -. [Q96CS7-4]
DR RefSeq; NP_001094093.1; NM_001100623.1. [Q96CS7-1]
DR RefSeq; NP_001253991.1; NM_001267062.1.
DR RefSeq; NP_001253992.1; NM_001267063.1.
DR RefSeq; NP_001253993.1; NM_001267064.1.
DR RefSeq; NP_001253994.1; NM_001267065.1. [Q96CS7-6]
DR RefSeq; NP_001253995.1; NM_001267066.1. [Q96CS7-5]
DR RefSeq; NP_001253996.1; NM_001267067.1.
DR RefSeq; NP_001253997.1; NM_001267068.1. [Q96CS7-4]
DR RefSeq; NP_001296377.1; NM_001309448.1.
DR RefSeq; NP_001296379.1; NM_001309450.1.
DR RefSeq; NP_001296380.1; NM_001309451.1.
DR RefSeq; NP_001296381.1; NM_001309452.1.
DR RefSeq; NP_060428.2; NM_017958.2. [Q96CS7-3]
DR RefSeq; XP_016859900.1; XM_017004411.1. [Q96CS7-6]
DR RefSeq; XP_016859901.1; XM_017004412.1. [Q96CS7-1]
DR PDB; 3AJ4; X-ray; 1.00 A; A/B=1-110.
DR PDB; 3VIA; X-ray; 1.75 A; A/B=1-110.
DR PDBsum; 3AJ4; -.
DR PDBsum; 3VIA; -.
DR AlphaFoldDB; Q96CS7; -.
DR SMR; Q96CS7; -.
DR BioGRID; 120370; 72.
DR IntAct; Q96CS7; 58.
DR MINT; Q96CS7; -.
DR STRING; 9606.ENSP00000385892; -.
DR iPTMnet; Q96CS7; -.
DR PhosphoSitePlus; Q96CS7; -.
DR BioMuta; PLEKHB2; -.
DR DMDM; 48474928; -.
DR EPD; Q96CS7; -.
DR jPOST; Q96CS7; -.
DR MassIVE; Q96CS7; -.
DR MaxQB; Q96CS7; -.
DR PaxDb; Q96CS7; -.
DR PeptideAtlas; Q96CS7; -.
DR PRIDE; Q96CS7; -.
DR ProteomicsDB; 3999; -.
DR ProteomicsDB; 5574; -.
DR ProteomicsDB; 7407; -.
DR ProteomicsDB; 76216; -. [Q96CS7-1]
DR ProteomicsDB; 76217; -. [Q96CS7-2]
DR ProteomicsDB; 76218; -. [Q96CS7-3]
DR Antibodypedia; 35075; 74 antibodies from 19 providers.
DR DNASU; 55041; -.
DR Ensembl; ENST00000234115.10; ENSP00000234115.6; ENSG00000115762.17. [Q96CS7-3]
DR Ensembl; ENST00000409158.5; ENSP00000386410.1; ENSG00000115762.17. [Q96CS7-6]
DR Ensembl; ENST00000409279.1; ENSP00000386666.1; ENSG00000115762.17. [Q96CS7-1]
DR Ensembl; ENST00000409612.5; ENSP00000386662.1; ENSG00000115762.17. [Q96CS7-1]
DR Ensembl; ENST00000438882.6; ENSP00000401193.2; ENSG00000115762.17. [Q96CS7-5]
DR Ensembl; ENST00000628582.2; ENSP00000487321.1; ENSG00000115762.17. [Q96CS7-4]
DR Ensembl; ENST00000693505.1; ENSP00000510611.1; ENSG00000115762.17. [Q96CS7-1]
DR GeneID; 55041; -.
DR KEGG; hsa:55041; -.
DR MANE-Select; ENST00000693505.1; ENSP00000510611.1; NM_001100623.2; NP_001094093.1.
DR UCSC; uc002tsf.5; human. [Q96CS7-1]
DR CTD; 55041; -.
DR GeneCards; PLEKHB2; -.
DR HGNC; HGNC:19236; PLEKHB2.
DR HPA; ENSG00000115762; Low tissue specificity.
DR MIM; 618452; gene.
DR neXtProt; NX_Q96CS7; -.
DR OpenTargets; ENSG00000115762; -.
DR PharmGKB; PA134885873; -.
DR VEuPathDB; HostDB:ENSG00000115762; -.
DR eggNOG; ENOG502S9ZQ; Eukaryota.
DR GeneTree; ENSGT00390000013989; -.
DR HOGENOM; CLU_1510070_0_0_1; -.
DR InParanoid; Q96CS7; -.
DR OMA; LEDKIHM; -.
DR OrthoDB; 1558185at2759; -.
DR PhylomeDB; Q96CS7; -.
DR TreeFam; TF331787; -.
DR PathwayCommons; Q96CS7; -.
DR SignaLink; Q96CS7; -.
DR BioGRID-ORCS; 55041; 8 hits in 1077 CRISPR screens.
DR ChiTaRS; PLEKHB2; human.
DR GeneWiki; PLEKHB2; -.
DR GenomeRNAi; 55041; -.
DR Pharos; Q96CS7; Tbio.
DR PRO; PR:Q96CS7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96CS7; protein.
DR Bgee; ENSG00000115762; Expressed in pons and 207 other tissues.
DR ExpressionAtlas; Q96CS7; baseline and differential.
DR Genevisible; Q96CS7; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:GO_Central.
DR GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039680; PLEKHB1/2.
DR InterPro; IPR039815; PLEKHB2.
DR PANTHER; PTHR14309; PTHR14309; 1.
DR PANTHER; PTHR14309:SF8; PTHR14309:SF8; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Endosome; Membrane; Reference proteome.
FT CHAIN 1..222
FT /note="Pleckstrin homology domain-containing family B
FT member 2"
FT /id="PRO_0000053889"
FT DOMAIN 2..109
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT BINDING 20
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-L-serine"
FT /ligand_id="ChEBI:CHEBI:57262"
FT VAR_SEQ 99..222
FT /note="AWKFTLQDSRTNTAYVGSAVMTDETSVVSSPPPYTAYAAPAPEQAYGYGPYG
FT GAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRERYRDNDSDLALGMLAGA
FT ATGMALGSLFWVF -> LMAMGHTVVRTRQELKLSTLRMGRRMPCPTSTHMQDFMDSSL
FT LTKSSFESAIETTTATWHWACWQEQPRAWP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045163"
FT VAR_SEQ 141
FT /note="E -> EVGRTLSLQ (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_047118"
FT VAR_SEQ 142..222
FT /note="QAYGYGPYGGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRER
FT YRDNDSDLALGMLAGAATGMALGSLFWVF -> ELHSKGPKIHTTTSAKTQAVLPTRCF
FT FPSESPIRRSVQISVLLPAVNIRRRIKLTFPQPARPRAPRSLCLWQTWFAGKRAPSLPT
FT AATAPALPSCPSPPAPSKALPPSLAGWRSPSSAPLPPEQALAPRSFQLSKHQARPRPHR
FT PGTPPVPAWPGVPPPPPARPPALR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009783"
FT VAR_SEQ 142..222
FT /note="QAYGYGPYGGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRER
FT YRDNDSDLALGMLAGAATGMALGSLFWVF -> DFMDSSLLTKSSFESAIETTTATWHW
FT ACWQEQPRAWP (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045164"
FT VAR_SEQ 142
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_009784"
FT CONFLICT 172
FT /note="Y -> H (in Ref. 1; BAA91379)"
FT /evidence="ECO:0000305"
FT STRAND 4..12
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 14..16
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 19..26
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 30..37
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 42..48
FT /evidence="ECO:0007829|PDB:3AJ4"
FT HELIX 49..52
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:3AJ4"
FT HELIX 59..61
FT /evidence="ECO:0007829|PDB:3AJ4"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 76..81
FT /evidence="ECO:0007829|PDB:3AJ4"
FT STRAND 86..90
FT /evidence="ECO:0007829|PDB:3AJ4"
FT HELIX 94..108
FT /evidence="ECO:0007829|PDB:3AJ4"
SQ SEQUENCE 222 AA; 24736 MW; 8924F61890D416A5 CRC64;
MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ
ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT
DETSVVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY
GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF
