ID   A6_VAR67                Reviewed;         372 AA.
AC   P0DSR1; P33833;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 7.
DE   RecName: Full=Protein A6;
GN   ORFNames=A6L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Plays an essential role in immature virion (IV) to mature
CC       virion (MV) transition. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A6 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49051.1; -; Genomic_DNA.
DR   EMBL; X67116; CAA47514.1; -; Genomic_DNA.
DR   PIR; G36848; G36848.
DR   RefSeq; NP_042154.1; NC_001611.1.
DR   SMR; P0DSR1; -.
DR   GeneID; 1486536; -.
DR   KEGG; vg:1486536; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR007008; Poxvirus_A6.
DR   Pfam; PF04924; Pox_A6; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Virion.
FT   CHAIN           1..372
FT                   /note="Protein A6"
FT                   /id="PRO_0000099223"
SQ   SEQUENCE   372 AA;  43149 MW;  9751173CE363452D CRC64;
     MDKLRVLYDE FVTISKDNLE RETGLSASDV DMDFDLNIFM TLVPVLEKKV CVITPTIEDD
     KIVTMMKYCS YQSFSFWFLK SGAVVKSVYN KLDDAEKEKF VATFKDMLLN VQTLISLNSM
     YTRLRQDTED IVSDSKKIME IVSHLRASTT ENAAYQVLQQ NNSFIISTLN KILSDENYLL
     KIIAVFDSKL ISEKETLNEY KQLYTISSES LVYGIRCVSN LDISSVQLSN NKYVLFVKKM
     LPKIILFQNN DINAQQFANV ISKIYTLIYR QLTSNVDVGC LLTDTIESTK TKISVEKFKQ
     TGINNVQSLI KFISDNKKEY KTIISEEYLS KEDRIITILQ NIVNEHDIKY DNNLLNMRDL
     IVTFRERYSY KF