ID   PKHB2_PONAB             Reviewed;         222 AA.
AC   Q5R4K6;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Pleckstrin homology domain-containing family B member 2;
DE            Short=PH domain-containing family B member 2;
DE   AltName: Full=Evectin-2;
GN   Name=PLEKHB2; Synonyms=EVT2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in retrograde transport of recycling endosomes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250};
CC       Peripheral membrane protein. Note=Specifically detected in
CC       tubulovesicular structures, and colocalizes with TFNR. {ECO:0000250}.
CC   -!- DOMAIN: The PH domain specifically binds phosphatidylserine, which is
CC       enriched in recycling endosome membranes, it doesn't recognize PIPs.
CC       {ECO:0000250}.
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DR   EMBL; CR860290; CAH92430.1; -; mRNA.
DR   EMBL; CR861240; CAH93310.1; -; mRNA.
DR   RefSeq; NP_001126433.1; NM_001132961.1.
DR   RefSeq; XP_009235868.1; XM_009237593.1.
DR   AlphaFoldDB; Q5R4K6; -.
DR   SMR; Q5R4K6; -.
DR   STRING; 9601.ENSPPYP00000014216; -.
DR   PRIDE; Q5R4K6; -.
DR   GeneID; 100173417; -.
DR   KEGG; pon:100173417; -.
DR   CTD; 55041; -.
DR   eggNOG; ENOG502S9ZQ; Eukaryota.
DR   HOGENOM; CLU_102020_0_0_1; -.
DR   InParanoid; Q5R4K6; -.
DR   OMA; LEDKIHM; -.
DR   TreeFam; TF331787; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039680; PLEKHB1/2.
DR   InterPro; IPR039815; PLEKHB2.
DR   PANTHER; PTHR14309; PTHR14309; 1.
DR   PANTHER; PTHR14309:SF8; PTHR14309:SF8; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Reference proteome.
FT   CHAIN           1..222
FT                   /note="Pleckstrin homology domain-containing family B
FT                   member 2"
FT                   /id="PRO_0000253638"
FT   DOMAIN          2..109
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   BINDING         20
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-L-serine"
FT                   /ligand_id="ChEBI:CHEBI:57262"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   222 AA;  24748 MW;  793F1741073D26DD CRC64;
     MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP VDCINIRTGQ
     ECRDIQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT
     DETSMVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY
     GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF