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PKHG6_HUMAN
ID   PKHG6_HUMAN             Reviewed;         790 AA.
AC   Q3KR16; Q3SWR1; Q8N1P1; Q8WYY1; Q9H8F4; Q9NVK9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 3.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Pleckstrin homology domain-containing family G member 6;
DE            Short=PH domain-containing family G member 6;
DE   AltName: Full=Myosin-interacting guanine nucleotide exchange factor;
DE            Short=MyoGEF;
GN   Name=PLEKHG6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   THR-35.
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA   Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA   Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT   "Large-scale cDNA transfection screening for genes related to cancer
RT   development and progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-35.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   FUNCTION, INTERACTION WITH MYH10, AND SUBCELLULAR LOCATION.
RX   PubMed=16721066; DOI=10.4161/cc.5.11.2815;
RA   Wu D., Asiedu M., Adelstein R.S., Wei Q.;
RT   "A novel guanine nucleotide exchange factor MyoGEF is required for
RT   cytokinesis.";
RL   Cell Cycle 5:1234-1239(2006).
RN   [7]
RP   FUNCTION, INTERACTION WITH ELMO1 AND EZR, SUBCELLULAR LOCATION, AND
RP   MUTAGENESIS OF ASN-351.
RX   PubMed=17881735; DOI=10.1091/mbc.e06-12-1144;
RA   D'Angelo R., Aresta S., Blangy A., Del Maestro L., Louvard D., Arpin M.;
RT   "Interaction of ezrin with the novel guanine nucleotide exchange factor
RT   PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in
RT   epithelial cells.";
RL   Mol. Biol. Cell 18:4780-4793(2007).
RN   [8]
RP   INTERACTION WITH CSPP1.
RX   PubMed=19129481; DOI=10.1091/mbc.e08-01-0001;
RA   Asiedu M., Wu D., Matsumura F., Wei Q.;
RT   "Centrosome/spindle pole-associated protein regulates cytokinesis via
RT   promoting the recruitment of MyoGEF to the central spindle.";
RL   Mol. Biol. Cell 20:1428-1440(2009).
CC   -!- FUNCTION: Guanine nucleotide exchange factor activating the small
CC       GTPase RHOA, which, in turn, induces myosin filament formation. Also
CC       activates RHOG. Does not activate RAC1, or to a much lower extent than
CC       RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and
CC       RHOA, at the cleavage furrow to advance furrow ingression during
CC       cytokinesis. In epithelial cells, required for the formation of
CC       microvilli and membrane ruffles on the apical pole. Along with EZR,
CC       required for normal macropinocytosis. {ECO:0000269|PubMed:16721066,
CC       ECO:0000269|PubMed:17881735}.
CC   -!- SUBUNIT: Interacts with MYH10. Interacts with ELMO1 and EZR (in an open
CC       conformation). Interacts with CSPP1. {ECO:0000269|PubMed:16721066,
CC       ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:19129481}.
CC   -!- INTERACTION:
CC       Q3KR16; Q53EZ4: CEP55; NbExp=8; IntAct=EBI-10240979, EBI-747776;
CC   -!- SUBCELLULAR LOCATION: Cell projection, microvillus
CC       {ECO:0000269|PubMed:17881735}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000269|PubMed:16721066}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000269|PubMed:16721066}. Cleavage furrow
CC       {ECO:0000269|PubMed:16721066}. Note=During mitosis, localizes to the
CC       spindle pole, central spindle and cleavage furrow (PubMed:16721066). In
CC       epithelial cells, recruited to the apical membrane by EZR where it
CC       participates in macropinocytosis (PubMed:17881735).
CC       {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q3KR16-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3KR16-2; Sequence=VSP_028857;
CC       Name=3;
CC         IsoId=Q3KR16-3; Sequence=VSP_028856, VSP_028858;
CC   -!- TISSUE SPECIFICITY: Highest expression in the placenta. Low levels in
CC       small intestine, lung, liver, kidney, thymus and heart.
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DR   EMBL; AK001527; BAA91741.1; -; mRNA.
DR   EMBL; AK095373; BAC04539.1; -; mRNA.
DR   EMBL; AF289613; AAL55797.1; -; mRNA.
DR   EMBL; BC104751; AAI04752.1; -; mRNA.
DR   EMBL; BC105961; AAI05962.1; -; mRNA.
DR   EMBL; BC109095; AAI09096.1; -; mRNA.
DR   EMBL; AC006057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471116; EAW88809.1; -; Genomic_DNA.
DR   CCDS; CCDS8541.1; -. [Q3KR16-1]
DR   RefSeq; NP_001138328.1; NM_001144856.1. [Q3KR16-1]
DR   RefSeq; NP_001138329.1; NM_001144857.1.
DR   RefSeq; NP_060643.2; NM_018173.3. [Q3KR16-1]
DR   RefSeq; XP_005253761.1; XM_005253704.4.
DR   AlphaFoldDB; Q3KR16; -.
DR   SMR; Q3KR16; -.
DR   BioGRID; 120497; 44.
DR   IntAct; Q3KR16; 32.
DR   STRING; 9606.ENSP00000380185; -.
DR   iPTMnet; Q3KR16; -.
DR   PhosphoSitePlus; Q3KR16; -.
DR   BioMuta; PLEKHG6; -.
DR   DMDM; 332278231; -.
DR   jPOST; Q3KR16; -.
DR   MassIVE; Q3KR16; -.
DR   PaxDb; Q3KR16; -.
DR   PeptideAtlas; Q3KR16; -.
DR   PRIDE; Q3KR16; -.
DR   ProteomicsDB; 61734; -. [Q3KR16-1]
DR   ProteomicsDB; 61735; -. [Q3KR16-2]
DR   ProteomicsDB; 61736; -. [Q3KR16-3]
DR   Antibodypedia; 49879; 141 antibodies from 21 providers.
DR   DNASU; 55200; -.
DR   Ensembl; ENST00000011684.11; ENSP00000011684.7; ENSG00000008323.16. [Q3KR16-1]
DR   Ensembl; ENST00000304581.8; ENSP00000304640.8; ENSG00000008323.16. [Q3KR16-3]
DR   Ensembl; ENST00000396988.7; ENSP00000380185.3; ENSG00000008323.16. [Q3KR16-1]
DR   Ensembl; ENST00000449001.6; ENSP00000393194.2; ENSG00000008323.16. [Q3KR16-2]
DR   Ensembl; ENST00000684764.1; ENSP00000506982.1; ENSG00000008323.16. [Q3KR16-1]
DR   GeneID; 55200; -.
DR   KEGG; hsa:55200; -.
DR   MANE-Select; ENST00000684764.1; ENSP00000506982.1; NM_001384598.1; NP_001371527.1.
DR   UCSC; uc001qnr.4; human. [Q3KR16-1]
DR   CTD; 55200; -.
DR   DisGeNET; 55200; -.
DR   GeneCards; PLEKHG6; -.
DR   HGNC; HGNC:25562; PLEKHG6.
DR   HPA; ENSG00000008323; Tissue enhanced (esophagus, intestine).
DR   MIM; 611743; gene.
DR   neXtProt; NX_Q3KR16; -.
DR   OpenTargets; ENSG00000008323; -.
DR   PharmGKB; PA142671165; -.
DR   VEuPathDB; HostDB:ENSG00000008323; -.
DR   eggNOG; KOG3521; Eukaryota.
DR   GeneTree; ENSGT00940000161250; -.
DR   HOGENOM; CLU_021968_1_0_1; -.
DR   InParanoid; Q3KR16; -.
DR   OMA; SPWESSE; -.
DR   OrthoDB; 556467at2759; -.
DR   PhylomeDB; Q3KR16; -.
DR   TreeFam; TF316755; -.
DR   PathwayCommons; Q3KR16; -.
DR   Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR   Reactome; R-HSA-9013149; RAC1 GTPase cycle.
DR   SignaLink; Q3KR16; -.
DR   SIGNOR; Q3KR16; -.
DR   BioGRID-ORCS; 55200; 16 hits in 1072 CRISPR screens.
DR   ChiTaRS; PLEKHG6; human.
DR   GenomeRNAi; 55200; -.
DR   Pharos; Q3KR16; Tbio.
DR   PRO; PR:Q3KR16; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q3KR16; protein.
DR   Bgee; ENSG00000008323; Expressed in mucosa of transverse colon and 125 other tissues.
DR   ExpressionAtlas; Q3KR16; baseline and differential.
DR   Genevisible; Q3KR16; HS.
DR   GO; GO:0030054; C:cell junction; IDA:HPA.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR042918; PLEKHG6.
DR   PANTHER; PTHR47671; PTHR47671; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..790
FT                   /note="Pleckstrin homology domain-containing family G
FT                   member 6"
FT                   /id="PRO_0000307912"
FT   DOMAIN          161..353
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          409..509
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          63..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          690..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..559
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..606
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..766
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..470
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15498874"
FT                   /id="VSP_028856"
FT   VAR_SEQ         1..46
FT                   /note="MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVL -> MG
FT                   CRLHAPGEKAAH (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_028857"
FT   VAR_SEQ         471..508
FT                   /note="SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQ -> MCPREGGRAS
FT                   TIHQKTEKAFGQLLCQPLGEPKIQHPLK (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15498874"
FT                   /id="VSP_028858"
FT   VARIANT         35
FT                   /note="A -> T (in dbSNP:rs740842)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_036710"
FT   MUTAGEN         351
FT                   /note="N->A: Loss of exchange activity."
FT                   /evidence="ECO:0000269|PubMed:17881735"
FT   CONFLICT        384
FT                   /note="E -> G (in Ref. 5; AAI04752)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        459
FT                   /note="E -> D (in Ref. 1; BAA91741)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   790 AA;  88960 MW;  34A2555DEF431EF4 CRC64;
     MKAFGPPHEG PLQGLVASRI ETYGGRHRAS AQSTAGRLYP RGYPVLDPSR RRLQQYVPFA
     RGSGQARGLS PMRLRDPEPE KRHGGHVGAG LLHSPKLKEL TKAHELEVRL HTFSMFGMPR
     LPPEDRRHWE IGEGGDSGLT IEKSWRELVP GHKEMSQELC HQQEALWELL TTELIYVRKL
     KIMTDLLAAG LLNLQRVGLL MEVSAETLFG NVPSLIRTHR SFWDEVLGPT LEETRASGQP
     LDPIGLQSGF LTFGQRFHPY VQYCLRVKQT MAYAREQQET NPLFHAFVQW CEKHKRSGRQ
     MLCDLLIKPH QRITKYPLLL HAVLKRSPEA RAQEALNAMI EAVESFLRHI NGQVRQGEEQ
     ESLAAAAQRI GPYEVLEPPS DEVEKNLRPF STLDLTSPML GVASEHTRQL LLEGPVRVKE
     GREGKLDVYL FLFSDVLLVT KPQRKADKAK VIRPPLMLEK LVCQPLRDPN SFLLIHLTEF
     QCVSSALLVH CPSPTDRAQW LEKTQQAQAA LQKLKAEEYV QQKRELLTLY RDQDRESPST
     RPSTPSLEGS QSSAEGRTPE FSTIIPHLVV TEDTDEDAPL VPDDTSDSGY GTLIPGTPTG
     SRSPLSRLRQ RALRRDPRLT FSTLELRDIP LRPHPPDPQA PQRRSAPELP EGILKGGSLP
     QEDPPTWSEE EDGASERGNV VVETLHRARL RGQLPSSPTH ADSAGESPWE SSGEEEEEGP
     LFLKAGHTSL RPMRAEDMLR EIREELASQR IEGAEEPRDS RPRKLTRAQL QRMRGPHIIQ
     LDTPLSASEV
 
 
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