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PKHG7_HUMAN
ID   PKHG7_HUMAN             Reviewed;         691 AA.
AC   Q6ZR37; A0A1X7SBZ7; B2RNR7; F5H4P0; Q32Q52;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Pleckstrin homology domain-containing family G member 7 {ECO:0000305};
DE            Short=PH domain-containing family G member 7;
GN   Name=PLEKHG7 {ECO:0000312|HGNC:HGNC:33829};
GN   Synonyms=C12orf74 {ECO:0000312|HGNC:HGNC:33829};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 276-691 (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-691 (ISOFORM 1).
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- INTERACTION:
CC       Q6ZR37; P21549: AGXT; NbExp=3; IntAct=EBI-12891828, EBI-727098;
CC       Q6ZR37; Q92870-2: APBB2; NbExp=3; IntAct=EBI-12891828, EBI-21535880;
CC       Q6ZR37; P54253: ATXN1; NbExp=6; IntAct=EBI-12891828, EBI-930964;
CC       Q6ZR37; P48643: CCT5; NbExp=3; IntAct=EBI-12891828, EBI-355710;
CC       Q6ZR37; G5E9A7: DMWD; NbExp=3; IntAct=EBI-12891828, EBI-10976677;
CC       Q6ZR37; P22607: FGFR3; NbExp=3; IntAct=EBI-12891828, EBI-348399;
CC       Q6ZR37; Q14957: GRIN2C; NbExp=3; IntAct=EBI-12891828, EBI-8285963;
CC       Q6ZR37; P28799: GRN; NbExp=3; IntAct=EBI-12891828, EBI-747754;
CC       Q6ZR37; P06396: GSN; NbExp=3; IntAct=EBI-12891828, EBI-351506;
CC       Q6ZR37; P04792: HSPB1; NbExp=3; IntAct=EBI-12891828, EBI-352682;
CC       Q6ZR37; P42858: HTT; NbExp=12; IntAct=EBI-12891828, EBI-466029;
CC       Q6ZR37; O60333-2: KIF1B; NbExp=3; IntAct=EBI-12891828, EBI-10975473;
CC       Q6ZR37; P35240: NF2; NbExp=3; IntAct=EBI-12891828, EBI-1014472;
CC       Q6ZR37; D3DTS7: PMP22; NbExp=3; IntAct=EBI-12891828, EBI-25882629;
CC       Q6ZR37; P50897: PPT1; NbExp=3; IntAct=EBI-12891828, EBI-1237011;
CC       Q6ZR37; O43741: PRKAB2; NbExp=3; IntAct=EBI-12891828, EBI-1053424;
CC       Q6ZR37; O60260-5: PRKN; NbExp=6; IntAct=EBI-12891828, EBI-21251460;
CC       Q6ZR37; P51149: RAB7A; NbExp=3; IntAct=EBI-12891828, EBI-1056089;
CC       Q6ZR37; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-12891828, EBI-396669;
CC       Q6ZR37; P37840: SNCA; NbExp=3; IntAct=EBI-12891828, EBI-985879;
CC       Q6ZR37; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-12891828, EBI-5235340;
CC       Q6ZR37; O15269-2: SPTLC1; NbExp=3; IntAct=EBI-12891828, EBI-25912901;
CC       Q6ZR37; Q86WV8: TSC1; NbExp=3; IntAct=EBI-12891828, EBI-12806590;
CC       Q6ZR37; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12891828, EBI-741480;
CC       Q6ZR37; O76024: WFS1; NbExp=3; IntAct=EBI-12891828, EBI-720609;
CC       Q6ZR37; Q9Y649; NbExp=3; IntAct=EBI-12891828, EBI-25900580;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6ZR37-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZR37-2; Sequence=VSP_061135, VSP_061136;
CC       Name=3;
CC         IsoId=Q6ZR37-3; Sequence=VSP_061133, VSP_061134;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI37087.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC87483.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC016136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC043363; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC105728; AAI05729.1; -; mRNA.
DR   EMBL; BC107813; AAI07814.1; -; mRNA.
DR   EMBL; BC137086; AAI37087.1; ALT_INIT; mRNA.
DR   EMBL; AK128530; BAC87483.1; ALT_INIT; mRNA.
DR   CCDS; CCDS41819.1; -. [Q6ZR37-2]
DR   CCDS; CCDS53818.1; -. [Q6ZR37-3]
DR   RefSeq; NP_001004330.1; NM_001004330.2.
DR   RefSeq; NP_001032760.1; NM_001037671.3. [Q6ZR37-2]
DR   RefSeq; NP_001171568.1; NM_001178097.2. [Q6ZR37-3]
DR   AlphaFoldDB; Q6ZR37; -.
DR   SMR; Q6ZR37; -.
DR   BioGRID; 130800; 168.
DR   BioGRID; 136300; 25.
DR   IntAct; Q6ZR37; 43.
DR   STRING; 9606.ENSP00000380933; -.
DR   iPTMnet; Q6ZR37; -.
DR   PhosphoSitePlus; Q6ZR37; -.
DR   BioMuta; C12orf74; -.
DR   BioMuta; PLEKHG7; -.
DR   DMDM; 74758773; -.
DR   jPOST; Q6ZR37; -.
DR   PaxDb; Q6ZR37; -.
DR   PeptideAtlas; Q6ZR37; -.
DR   PRIDE; Q6ZR37; -.
DR   ProteomicsDB; 26631; -.
DR   ProteomicsDB; 61630; -.
DR   Antibodypedia; 66814; 13 antibodies from 8 providers.
DR   DNASU; 440107; -.
DR   Ensembl; ENST00000344636.6; ENSP00000344961.5; ENSG00000187510.11. [Q6ZR37-1]
DR   Ensembl; ENST00000397833.3; ENSP00000380933.3; ENSG00000187510.11. [Q6ZR37-2]
DR   Ensembl; ENST00000544406.2; ENSP00000446043.2; ENSG00000187510.11. [Q6ZR37-3]
DR   GeneID; 440107; -.
DR   KEGG; hsa:440107; -.
DR   MANE-Select; ENST00000344636.6; ENSP00000344961.5; NM_001377329.1; NP_001364258.1.
DR   UCSC; uc001tcj.3; human. [Q6ZR37-1]
DR   CTD; 440107; -.
DR   GeneCards; PLEKHG7; -.
DR   HGNC; HGNC:33829; PLEKHG7.
DR   HPA; ENSG00000187510; Tissue enhanced (cervix, epididymis, fallopian tube).
DR   neXtProt; NX_Q6ZR37; -.
DR   OpenTargets; ENSG00000187510; -.
DR   PharmGKB; PA162399708; -.
DR   VEuPathDB; HostDB:ENSG00000187510; -.
DR   eggNOG; ENOG502S9PS; Eukaryota.
DR   eggNOG; KOG3521; Eukaryota.
DR   GeneTree; ENSGT00510000046843; -.
DR   HOGENOM; CLU_030833_0_0_1; -.
DR   InParanoid; Q6ZR37; -.
DR   OMA; WDEVMET; -.
DR   OrthoDB; 368523at2759; -.
DR   PhylomeDB; Q6ZR37; -.
DR   TreeFam; TF316247; -.
DR   TreeFam; TF353652; -.
DR   PathwayCommons; Q6ZR37; -.
DR   SignaLink; Q6ZR37; -.
DR   BioGRID-ORCS; 338809; 9 hits in 1027 CRISPR screens.
DR   BioGRID-ORCS; 440107; 9 hits in 1058 CRISPR screens.
DR   ChiTaRS; PLEKHG7; human.
DR   GenomeRNAi; 440107; -.
DR   Pharos; Q6ZR37; Tdark.
DR   PRO; PR:Q6ZR37; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q6ZR37; protein.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR040181; PKHG5/7.
DR   PANTHER; PTHR13217; PTHR13217; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Reference proteome.
FT   CHAIN           1..691
FT                   /note="Pleckstrin homology domain-containing family G
FT                   member 7"
FT                   /id="PRO_0000317287"
FT   DOMAIN          313..488
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          535..668
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        395
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         170..173
FT                   /note="GEEL -> VTQL (in isoform 3)"
FT                   /id="VSP_061133"
FT   VAR_SEQ         174..691
FT                   /note="Missing (in isoform 3)"
FT                   /id="VSP_061134"
FT   VAR_SEQ         178..190
FT                   /note="FYEHRRSSVVLNL -> CVCIYFLRCYDIC (in isoform 2)"
FT                   /id="VSP_061135"
FT   VAR_SEQ         191..691
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_061136"
FT   VARIANT         411
FT                   /note="D -> G (in dbSNP:rs17790310)"
FT                   /id="VAR_050513"
FT   VARIANT         524
FT                   /note="M -> T (in dbSNP:rs924326)"
FT                   /id="VAR_050514"
SQ   SEQUENCE   691 AA;  79526 MW;  384CE88882B6E6D2 CRC64;
     MEKTESFCPE VPPQDCGASP RPSLRSLPKN QGSLLQFDRQ APGRISTSPT LRRLRTRGCG
     TRQDAWQVTT WGSWGAPVGF PCYLSKSLPG SPKDSSHLLS PLRLHSRLTS EPERALNAAD
     SLEPQTRPTD KYLPPELQPV NEGSLHQASL RQQEGHFLPS PTLRHPSPQG EELHPSRFYE
     HRRSSVVLNL PGLEVFPGDL LVSDGAADYL CHPLLLLNSE SKKPRWPFSK RGVGKDKHKH
     ISDLENCLSS VKITSFRGYD FYGLKDKTWD EVLETHHKLP TDQLDLKKQQ EAVWELFTSE
     CTYFLDHLLV LKMIFMNTLR YLQTHEYLLD VDLWRLFANL EELTQTSLGF VNSLFGIIKD
     YVDASEISSS LDFISVLTKY FRGSLCQSHQ TYCLNYSAAI FYLESLRQRD DFGIYLKWCE
     QNEQCRRLHV PELLVAPLQR LTRYPLLLKN IWKRSMDSAE KIMIYSIKEK VEKSIRDLEG
     KVKWLDNFQK FRYLQEIIVW PPLWDRDKRF FIPECLKHIF KEHMAENILS PTSRHLLYEG
     KLTLAESTRF LDVYLFLFND FLLVTKTKCN KKKLGGSDPG LMCPSLTPEL QAVIKEGGSC
     TVLDQPIPLD RLVVKSIEPL HVSVFGLRNA FLIQHENRYR QCIAAFLLQA QTENIKKTWM
     AQITTAISCF TKSQETKKIS LFTLPAESSE I
 
 
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