ID   PKHH1_DANRE             Reviewed;        1433 AA.
AC   Q00IB7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Pleckstrin homology domain-containing family H member 1;
DE            Short=PH domain-containing family H member 1;
DE   AltName: Full=Protein max-1 homolog;
GN   Name=plekhh1; Synonyms=max1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Kidney marrow;
RX   PubMed=17065323; DOI=10.1073/pnas.0603959103;
RA   Zhong H., Wu X., Huang H., Fan Q., Zhu Z., Lin S.;
RT   "Vertebrate MAX-1 is required for vascular patterning in zebrafish.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:16800-16805(2006).
CC   -!- FUNCTION: Critical component of the guidance pathway underlying
CC       endothelial cell migration and blood vessel patterning. Involved in
CC       mediating membrane localization of ephrin proteins, which have been
CC       shown to provide guidance cues for endothelial cell migration.
CC       {ECO:0000269|PubMed:17065323}.
CC   -!- DEVELOPMENTAL STAGE: Specifically expressed in subsets of neuronal
CC       tissues, epithelial cells, and developing somites through which
CC       vascular endothelial cells migrate from large ventral axial vessels to
CC       form stereotypic intersegmental blood vessels (ISV).
CC       {ECO:0000269|PubMed:17065323}.
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DR   EMBL; DQ501275; ABI31621.1; -; mRNA.
DR   RefSeq; NP_001070987.1; NM_001077519.2.
DR   AlphaFoldDB; Q00IB7; -.
DR   SMR; Q00IB7; -.
DR   STRING; 7955.ENSDARP00000070420; -.
DR   PaxDb; Q00IB7; -.
DR   PRIDE; Q00IB7; -.
DR   GeneID; 565914; -.
DR   KEGG; dre:565914; -.
DR   CTD; 57475; -.
DR   ZFIN; ZDB-GENE-061219-1; plekhh1.
DR   eggNOG; KOG0248; Eukaryota.
DR   InParanoid; Q00IB7; -.
DR   OrthoDB; 75793at2759; -.
DR   PhylomeDB; Q00IB7; -.
DR   PRO; PR:Q00IB7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0048514; P:blood vessel morphogenesis; IMP:ZFIN.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:ZFIN.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; -; 1.
DR   Gene3D; 2.30.29.30; -; 3.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR040105; PKHH1.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR22903:SF4; PTHR22903:SF4; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Reference proteome; Repeat.
FT   CHAIN           1..1433
FT                   /note="Pleckstrin homology domain-containing family H
FT                   member 1"
FT                   /id="PRO_0000310950"
FT   DOMAIN          643..737
FT                   /note="PH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          751..859
FT                   /note="PH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          896..1050
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT   DOMAIN          1061..1392
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          247..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          40..174
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        249..263
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..298
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..346
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..583
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1433 AA;  160045 MW;  24EE621E2B1B8CE3 CRC64;
     MAEVMESVST AVVPNSSVDW QKRCIALETQ LMRFRLQAGN IRHLLAERMQ ELEQRVIEAD
     QRAESAEKQV HIMEEKLKSA NMQPSETENS LYRSYQELSN QIQEKDLIVK RLEGQLEKQN
     LVRAQEAEII EEKAAKIKDW VTFKLREMET ENQQLKKANL KQTEQILMLQ DKLQTLLERP
     MSPAVDTHLV PSSPLHPPSC PGTPPAQEDC WRLPGCRLNS SADSKRKITE GCDSAFHSAS
     LLPMLQDKAD SPKSSQDGVD ATSTVKESAE GVEPSFGVMR DRAMGGASDR DHSSDELNSK
     FRSQCLRSSS SSSSSSSSAY ETPGPGGFDT PTPTPKSPPP VSLSPPLTRL PLSCPFPLAL
     PLGTSMTLPK VRTPLTPRDS IQLVKKHHSQ PQPGLERLHQ VNVSIDIGNC GSPSCHSLVP
     GSAPSHGLEE TDIDEGTPES MEVVVEGSEI TEAQPNDGDL LDGLTKELEM MDPEALKPPT
     PPLHRFPSWE SRIYAVAKLG MRVSEACLGA KTIGRVSTQP QHSTTGPFTH LIYKNISVPV
     YSTLKGKATQ ISSVPLPDDD SGSEDDSSSL ASLHTSTLGP DKKGSTPGSP RAVKRGVSTS
     SISSESDYAI PPDAYSLDSD CSEPEHKVQR TSSYSCESVG PETLEKTGYL LKMGSQVKAW
     KRRWFILRNG EILYYKSPSD VIRKPQGQME LNSSCHIARG EGAQTFQLIT EKKTFYLAAD
     SPNILEDWIR VLQNVLKVQA SGPISMDKEV KPTARGWLTK VKHGHSKLVW CALIGKVFYY
     YRNQEDKFPL GQLRVREARV EEVDRSCDSD EDYEAGGRGF LSSHFTLVVH PKEQSPTYLL
     VGTKQEKDTW LYHLTVAAGS SASLRVGTEF EQLIGKLLDV DGVSDSALWK REVLCFSKEG
     LRYPLTTLPS EALQTEAIKL FKSCQLFINV LVESPSIDYH TSLAQNALQV CLTHPELQNE
     MYCQLIKQTN CRTPHNYALT QCWQLLSLCV ALFLPQHHFL WYLRQYLQRN ADPRTEVGKY
     AVYCQRSVER TLQNGEREAK PSRMEILSIL LRNPYHHSLP FSIPVHFMNN TYEVVGFDGS
     TTVEEFLNTV NQRTGMRKPQ ISGFALFTDD PSGKDLEHCL QPANKICDVI SKWEQALKEL
     HPGKYEGTRT VRLTYKSRLC FRAQAKGETE RERLLLAYQV NDEVLQGHFP VSKELALEVA
     ALMAQVEYGD LDRAAMSPVG SPQPKTQQTL LQVLERFYPK RYKQECSVEQ LRELGERLVA
     TKWSVLRGCT ASECVRIYLT VARKWPLFGA KLFNAKPLPP SSLDRTQVWL AVNEDGLSVL
     DYTMYPLVTY PYQSVITFGG CKEDFMLVVS LIKDQALGKK TVDKLLFAMA KPKILELTLL
     IASYINYWTS SLPGASNQTQ SSTLGAQGDK KLWDIDSRHF PSMTYTTKGP TLL