ID   PKHH3_RAT               Reviewed;         791 AA.
AC   Q3B7L1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Pleckstrin homology domain-containing family H member 3;
DE            Short=PH domain-containing family H member 3;
DE   Flags: Precursor;
GN   Name=Plekhh3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC107561; AAI07562.1; -; mRNA.
DR   RefSeq; NP_001032279.1; NM_001037202.1.
DR   AlphaFoldDB; Q3B7L1; -.
DR   SMR; Q3B7L1; -.
DR   STRING; 10116.ENSRNOP00000027452; -.
DR   PaxDb; Q3B7L1; -.
DR   PRIDE; Q3B7L1; -.
DR   GeneID; 360634; -.
DR   KEGG; rno:360634; -.
DR   UCSC; RGD:1304854; rat.
DR   CTD; 79990; -.
DR   RGD; 1304854; Plekhh3.
DR   VEuPathDB; HostDB:ENSRNOG00000020238; -.
DR   eggNOG; KOG4229; Eukaryota.
DR   HOGENOM; CLU_001626_4_0_1; -.
DR   InParanoid; Q3B7L1; -.
DR   OMA; QDSKNTF; -.
DR   OrthoDB; 478730at2759; -.
DR   PhylomeDB; Q3B7L1; -.
DR   PRO; PR:Q3B7L1; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000020238; Expressed in quadriceps femoris and 18 other tissues.
DR   Genevisible; Q3B7L1; RN.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; -; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Methylation; Phosphoprotein; Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..791
FT                   /note="Pleckstrin homology domain-containing family H
FT                   member 3"
FT                   /id="PRO_0000311110"
FT   DOMAIN          95..199
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          237..399
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT   DOMAIN          404..755
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          29..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          549..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          593..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..577
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..791
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z736"
FT   MOD_RES         636
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z736"
SQ   SEQUENCE   791 AA;  85169 MW;  9A02A9860FCB7653 CRC64;
     MPLPGGLWWL LCCRRGFTLL HRDYGDGELS GDGDEDEDDE TFELRSPSPA GGGRGSLDVT
     LTQPTRNGPI TDRLQSWEET WSLIPDKGLP EDDPDVIVKG WLYREPRGGG ARPWLLPRRA
     WFVLTRDSLD QFSSSGKGAR RLGSLVLTSL CSVTGPERRP KETGLWSVTV SGRKHSIRLC
     SPRQAEAERW GVALREVIAS KAPLETPTQL LLRDIQESGG DPEAVALIYR RNPILRHTSS
     ALYAPLLPLP YEVSAPGPGY APLREEAVRL FLALQALEGA RRPGPLMQGV LQTCRDLPAL
     QDELFLQLAK QTSGPAGPPG LPATQDPAAL RYWQLLTCMS CTFRPGGAVR GHLLGHLERT
     EQALPDSELA EYARFIRKAL GRTRGRELVP SLAEISALSR RQELLCTVHC PGAGACPVSI
     DSHTTAGEVA RELVGRLGLA RSRNAFALYE QRGAQERALA GGTLVADVLT SLTSEEVGLE
     DSPDSGWRLC LRLHGPLHPE GLSPEGHELP FLFEQAHALL LRGRPPPPDD TLRALAALRL
     QSLHRDFSPR GPLPLLDRLM PPPAPPREQP SRPARRPPPS AALLAGALWS PGLAKRRAER
     ARRIGTGRST ESTAQVGGGG GGSTTAAVLG GWKRLRGMGQ AEAMAAYLAL AAQCPGFGAA
     RYDVLELSTE PGGGAPQKLC LGLGAKAMSL SRPGESEPIH SVSYGHVAAC QLIGPHTLAL
     RVGDSQLLLQ SPQVEEIMEL VNAYLANPSP ERPCSSSGPP SQDLSDTSPP SQHQVLEKPQ
     GQSGCLRQLQ D