PKHJ1_HUMAN
ID PKHJ1_HUMAN Reviewed; 149 AA.
AC Q9NW61; B3KUQ9; D6W604;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Pleckstrin homology domain-containing family J member 1;
DE Short=PH domain-containing family J member 1;
DE AltName: Full=Guanine nucleotide-releasing protein x;
GN Name=PLEKHJ1; Synonyms=GNRPX;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=11602354; DOI=10.1016/s0378-1119(01)00690-4;
RA Dresser D.W., Jamin S.P., Atkins C.J., Guerrier D.;
RT "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2
RT (SAP62) immediately upstream of AMH.";
RL Gene 277:163-173(2001).
CC -!- INTERACTION:
CC Q9NW61; Q14657: LAGE3; NbExp=3; IntAct=EBI-1057560, EBI-1052105;
CC Q9NW61; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-1057560, EBI-741158;
CC Q9NW61; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-1057560, EBI-14131832;
CC Q9NW61; Q6ICB4: PHETA2; NbExp=4; IntAct=EBI-1057560, EBI-11081747;
CC Q9NW61; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-1057560, EBI-10232538;
CC -!- TISSUE SPECIFICITY: Expressed in testis and liver.
CC {ECO:0000269|PubMed:11602354}.
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DR EMBL; AK001159; BAA91525.1; -; mRNA.
DR EMBL; AK097723; BAG53521.1; -; mRNA.
DR EMBL; CR457253; CAG33534.1; -; mRNA.
DR EMBL; CH471139; EAW69405.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69406.1; -; Genomic_DNA.
DR EMBL; BC003084; AAH03084.1; -; mRNA.
DR EMBL; BC008966; AAH08966.1; -; mRNA.
DR CCDS; CCDS12083.1; -.
DR RefSeq; NP_060519.1; NM_018049.2.
DR AlphaFoldDB; Q9NW61; -.
DR SMR; Q9NW61; -.
DR BioGRID; 120421; 29.
DR IntAct; Q9NW61; 11.
DR MINT; Q9NW61; -.
DR STRING; 9606.ENSP00000464955; -.
DR iPTMnet; Q9NW61; -.
DR PhosphoSitePlus; Q9NW61; -.
DR BioMuta; PLEKHJ1; -.
DR DMDM; 74753007; -.
DR EPD; Q9NW61; -.
DR MassIVE; Q9NW61; -.
DR MaxQB; Q9NW61; -.
DR PaxDb; Q9NW61; -.
DR PeptideAtlas; Q9NW61; -.
DR PRIDE; Q9NW61; -.
DR ProteomicsDB; 82896; -.
DR Antibodypedia; 22945; 140 antibodies from 25 providers.
DR DNASU; 55111; -.
DR Ensembl; ENST00000326631.7; ENSP00000318075.2; ENSG00000104886.12.
DR Ensembl; ENST00000589097.6; ENSP00000465391.1; ENSG00000104886.12.
DR GeneID; 55111; -.
DR KEGG; hsa:55111; -.
DR MANE-Select; ENST00000326631.7; ENSP00000318075.2; NM_018049.3; NP_060519.1.
DR UCSC; uc002lvf.2; human.
DR CTD; 55111; -.
DR GeneCards; PLEKHJ1; -.
DR HGNC; HGNC:18211; PLEKHJ1.
DR HPA; ENSG00000104886; Low tissue specificity.
DR MIM; 617834; gene.
DR neXtProt; NX_Q9NW61; -.
DR PharmGKB; PA134936152; -.
DR VEuPathDB; HostDB:ENSG00000104886; -.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT00390000005235; -.
DR HOGENOM; CLU_141382_0_0_1; -.
DR InParanoid; Q9NW61; -.
DR OMA; EEQCKEW; -.
DR PhylomeDB; Q9NW61; -.
DR PathwayCommons; Q9NW61; -.
DR SignaLink; Q9NW61; -.
DR BioGRID-ORCS; 55111; 33 hits in 1076 CRISPR screens.
DR ChiTaRS; PLEKHJ1; human.
DR GenomeRNAi; 55111; -.
DR Pharos; Q9NW61; Tdark.
DR PRO; PR:Q9NW61; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NW61; protein.
DR Bgee; ENSG00000104886; Expressed in mucosa of transverse colon and 96 other tissues.
DR ExpressionAtlas; Q9NW61; baseline and differential.
DR Genevisible; Q9NW61; HS.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; PTHR22902; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..149
FT /note="Pleckstrin homology domain-containing family J
FT member 1"
FT /id="PRO_0000309230"
FT DOMAIN 15..108
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ SEQUENCE 149 AA; 17551 MW; 14FB8E77A88C4C7E CRC64;
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT DEAEPVGALL
LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM EALRRASYEF MRRSLIFYRN
EIRKVTGKDP LEQFGISEEA RFQLSGLQA
