PKHJ1_MOUSE
ID PKHJ1_MOUSE Reviewed; 164 AA.
AC Q9D240; Q8BQ13; Q9EPF0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Pleckstrin homology domain-containing family J member 1;
DE Short=PH domain-containing family J member 1;
DE AltName: Full=Guanine nucleotide-releasing protein x;
GN Name=Plekhj1; Synonyms=Gnrpx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Spinal ganglion, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-121.
RC STRAIN=129;
RX PubMed=11602354; DOI=10.1016/s0378-1119(01)00690-4;
RA Dresser D.W., Jamin S.P., Atkins C.J., Guerrier D.;
RT "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2
RT (SAP62) immediately upstream of AMH.";
RL Gene 277:163-173(2001).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34743.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK020621; BAB32152.1; -; mRNA.
DR EMBL; AK051734; BAC34743.1; ALT_FRAME; mRNA.
DR EMBL; AK150144; BAE29339.1; -; mRNA.
DR EMBL; BC005565; AAH05565.1; -; mRNA.
DR EMBL; X83733; CAC10448.1; -; Genomic_DNA.
DR CCDS; CCDS48640.1; -.
DR RefSeq; NP_076389.2; NM_023900.2.
DR AlphaFoldDB; Q9D240; -.
DR SMR; Q9D240; -.
DR STRING; 10090.ENSMUSP00000042334; -.
DR iPTMnet; Q9D240; -.
DR PhosphoSitePlus; Q9D240; -.
DR EPD; Q9D240; -.
DR MaxQB; Q9D240; -.
DR PaxDb; Q9D240; -.
DR PRIDE; Q9D240; -.
DR ProteomicsDB; 289910; -.
DR Antibodypedia; 22945; 140 antibodies from 25 providers.
DR DNASU; 78670; -.
DR Ensembl; ENSMUST00000036805; ENSMUSP00000042334; ENSMUSG00000035278.
DR GeneID; 78670; -.
DR KEGG; mmu:78670; -.
DR UCSC; uc007ger.1; mouse.
DR CTD; 55111; -.
DR MGI; MGI:1925920; Plekhj1.
DR VEuPathDB; HostDB:ENSMUSG00000035278; -.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT00390000005235; -.
DR HOGENOM; CLU_141382_0_0_1; -.
DR InParanoid; Q9D240; -.
DR OMA; EEQCKEW; -.
DR OrthoDB; 1068073at2759; -.
DR PhylomeDB; Q9D240; -.
DR TreeFam; TF331914; -.
DR BioGRID-ORCS; 78670; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Plekhj1; mouse.
DR PRO; PR:Q9D240; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9D240; protein.
DR Bgee; ENSMUSG00000035278; Expressed in spermatocyte and 221 other tissues.
DR ExpressionAtlas; Q9D240; baseline and differential.
DR Genevisible; Q9D240; MM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; PTHR22902; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..164
FT /note="Pleckstrin homology domain-containing family J
FT member 1"
FT /id="PRO_0000309231"
FT DOMAIN 15..108
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ SEQUENCE 164 AA; 19029 MW; BC12184105EBE585 CRC64;
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVAKRRLVKL VVNFLFYFRP DEAEPLGALL
LERCRVAQEE PGGFSISFVE DLSRKYHFEC CSQEQCQDWM EALQRASYEY MRQSLIFYRN
EIRKMTGKDP LEQFGISEEA RFQLNSLPKD GRTTCIGSQL NVLD
