PKHL1_HUMAN
ID PKHL1_HUMAN Reviewed; 4243 AA.
AC Q86WI1; Q567P2; Q9UF27;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Fibrocystin-L;
DE AltName: Full=Polycystic kidney and hepatic disease 1-like protein 1;
DE Short=PKHD1-like protein 1;
DE Flags: Precursor;
GN Name=PKHD1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT LEU-1965.
RX PubMed=12620974; DOI=10.1093/hmg/ddg068;
RA Hogan M.C., Griffin M.D., Rossetti S., Torres V.E., Ward C.J., Harris P.C.;
RT "PKHDL1, a homolog of the autosomal recessive polycystic kidney disease
RT gene, encodes a receptor with inducible T lymphocyte expression.";
RL Hum. Mol. Genet. 12:685-698(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-268.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3820-4243.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Expressed in spleen and thymus as well
CC as in activated T-cells and B-lymphoblasts.
CC {ECO:0000269|PubMed:12620974}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH93096.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY219181; AAO60072.1; -; mRNA.
DR EMBL; AC021001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093096; AAH93096.1; ALT_SEQ; mRNA.
DR EMBL; AL133640; CAB63761.1; -; mRNA.
DR CCDS; CCDS47911.1; -.
DR PIR; T43498; T43498.
DR RefSeq; NP_803875.2; NM_177531.4.
DR SMR; Q86WI1; -.
DR BioGRID; 124996; 2.
DR DIP; DIP-59023N; -.
DR IntAct; Q86WI1; 2.
DR MINT; Q86WI1; -.
DR STRING; 9606.ENSP00000367655; -.
DR CarbonylDB; Q86WI1; -.
DR GlyGen; Q86WI1; 8 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q86WI1; -.
DR PhosphoSitePlus; Q86WI1; -.
DR BioMuta; PKHD1L1; -.
DR DMDM; 269849629; -.
DR jPOST; Q86WI1; -.
DR MassIVE; Q86WI1; -.
DR PaxDb; Q86WI1; -.
DR PeptideAtlas; Q86WI1; -.
DR PRIDE; Q86WI1; -.
DR ProteomicsDB; 70165; -.
DR Antibodypedia; 26574; 16 antibodies from 9 providers.
DR DNASU; 93035; -.
DR Ensembl; ENST00000378402.10; ENSP00000367655.5; ENSG00000205038.12.
DR GeneID; 93035; -.
DR KEGG; hsa:93035; -.
DR MANE-Select; ENST00000378402.10; ENSP00000367655.5; NM_177531.6; NP_803875.2.
DR UCSC; uc003yne.4; human.
DR CTD; 93035; -.
DR DisGeNET; 93035; -.
DR GeneCards; PKHD1L1; -.
DR HGNC; HGNC:20313; PKHD1L1.
DR HPA; ENSG00000205038; Tissue enriched (thyroid).
DR MIM; 607843; gene.
DR neXtProt; NX_Q86WI1; -.
DR OpenTargets; ENSG00000205038; -.
DR PharmGKB; PA134950222; -.
DR VEuPathDB; HostDB:ENSG00000205038; -.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT00940000157594; -.
DR HOGENOM; CLU_000057_1_0_1; -.
DR InParanoid; Q86WI1; -.
DR OMA; RSFPQKM; -.
DR OrthoDB; 323806at2759; -.
DR PhylomeDB; Q86WI1; -.
DR TreeFam; TF329582; -.
DR PathwayCommons; Q86WI1; -.
DR SignaLink; Q86WI1; -.
DR BioGRID-ORCS; 93035; 10 hits in 1069 CRISPR screens.
DR ChiTaRS; PKHD1L1; human.
DR GenomeRNAi; 93035; -.
DR Pharos; Q86WI1; Tdark.
DR PRO; PR:Q86WI1; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q86WI1; protein.
DR Bgee; ENSG00000205038; Expressed in right uterine tube and 119 other tissues.
DR ExpressionAtlas; Q86WI1; baseline and differential.
DR Genevisible; Q86WI1; HS.
DR GO; GO:0005829; C:cytosol; TAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0120234; C:stereocilium coat; IEA:Ensembl.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; NAS:UniProtKB.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR Gene3D; 2.160.20.10; -; 1.
DR Gene3D; 2.60.40.10; -; 14.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR029927; PKHDL1.
DR PANTHER; PTHR46769:SF4; PTHR46769:SF4; 3.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 14.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 14.
DR SMART; SM00758; PA14; 1.
DR SMART; SM00710; PbH1; 10.
DR SUPFAM; SSF49503; SSF49503; 1.
DR SUPFAM; SSF51126; SSF51126; 1.
DR SUPFAM; SSF81296; SSF81296; 14.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..4243
FT /note="Fibrocystin-L"
FT /id="PRO_0000318572"
FT TOPO_DOM 21..4210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4211..4231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 4232..4243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..129
FT /note="IPT/TIG 1"
FT DOMAIN 146..255
FT /note="IPT/TIG 2"
FT DOMAIN 270..361
FT /note="IPT/TIG 3"
FT DOMAIN 337..492
FT /note="PA14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01164"
FT DOMAIN 1067..1151
FT /note="IPT/TIG 4"
FT DOMAIN 1155..1234
FT /note="IPT/TIG 5"
FT DOMAIN 1240..1322
FT /note="IPT/TIG 6"
FT DOMAIN 1330..1469
FT /note="IPT/TIG 7"
FT DOMAIN 1566..1649
FT /note="IPT/TIG 8"
FT DOMAIN 1659..1743
FT /note="IPT/TIG 9"
FT DOMAIN 1749..1828
FT /note="IPT/TIG 10"
FT DOMAIN 1831..1910
FT /note="IPT/TIG 11"
FT DOMAIN 1916..1997
FT /note="IPT/TIG 12"
FT DOMAIN 1999..2085
FT /note="IPT/TIG 13"
FT DOMAIN 2091..2176
FT /note="IPT/TIG 14"
FT DOMAIN 2184..2304
FT /note="G8 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00817"
FT REPEAT 2508..2530
FT /note="PbH1 1"
FT REPEAT 2566..2588
FT /note="PbH1 2"
FT REPEAT 2665..2687
FT /note="PbH1 3"
FT REPEAT 2733..2756
FT /note="PbH1 4"
FT DOMAIN 3036..3174
FT /note="G8 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00817"
FT REPEAT 3293..3315
FT /note="PbH1 5"
FT REPEAT 3355..3377
FT /note="PbH1 6"
FT REPEAT 3416..3438
FT /note="PbH1 7"
FT REPEAT 3471..3493
FT /note="PbH1 8"
FT REPEAT 3527..3548
FT /note="PbH1 9"
FT CARBOHYD 122
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 445
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1803
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1839
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2320
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3736
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT VARIANT 373
FT /note="W -> C (in dbSNP:rs16879428)"
FT /id="VAR_038760"
FT VARIANT 440
FT /note="Y -> H (in dbSNP:rs964307)"
FT /id="VAR_038761"
FT VARIANT 923
FT /note="H -> R (in dbSNP:rs4735133)"
FT /id="VAR_038762"
FT VARIANT 943
FT /note="Y -> H (in dbSNP:rs16879534)"
FT /id="VAR_038763"
FT VARIANT 957
FT /note="A -> E (in dbSNP:rs35375999)"
FT /id="VAR_038764"
FT VARIANT 1192
FT /note="T -> A (in dbSNP:rs10093885)"
FT /id="VAR_038765"
FT VARIANT 1514
FT /note="R -> S (in dbSNP:rs1673408)"
FT /id="VAR_038766"
FT VARIANT 1539
FT /note="T -> R (in dbSNP:rs7820062)"
FT /id="VAR_038767"
FT VARIANT 1965
FT /note="V -> L (in dbSNP:rs1673407)"
FT /evidence="ECO:0000269|PubMed:12620974"
FT /id="VAR_038768"
FT VARIANT 3050
FT /note="H -> Q (in dbSNP:rs1783147)"
FT /id="VAR_038769"
FT VARIANT 3080
FT /note="V -> I (in dbSNP:rs10441509)"
FT /id="VAR_038770"
FT VARIANT 3411
FT /note="I -> V (in dbSNP:rs16879659)"
FT /id="VAR_038771"
FT VARIANT 3607
FT /note="D -> E (in dbSNP:rs9774677)"
FT /id="VAR_038772"
FT VARIANT 3862
FT /note="L -> F (in dbSNP:rs16879693)"
FT /id="VAR_038773"
FT VARIANT 4220
FT /note="V -> I (in dbSNP:rs1783174)"
FT /id="VAR_038774"
FT CONFLICT 4061
FT /note="K -> N (in Ref. 4; CAB63761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 4243 AA; 465734 MW; A3A50CA85C5DA500 CRC64;
MGHLWLLGIW GLCGLLLCAA DPSTDGSQII PKVTEIIPKY GSINGATRLT IRGEGFSQAN
QFNYGVDNAE LGNSVQLISS FQSITCDVEK DASHSTQITC YTRAMPEDSY TVRVSVDGVP
VTENNTCKGH INSWECTFNA KSFRTPTIRS ITPLSGTPGT LITIQGRIFT DVYGSNIALS
SNGKNVRILR VYIGGMPCEL LIPQSDNLYG LKLDHPNGDM GSMVCKTTGT FIGHHNVSFI
LDNDYGRSFP QKMAYFVSSL NKIAMFQTYA EVTMIFPSQG SIRGGTTLTI SGRFFDQTDF
PVRVLVGGEP CDILNVTENS ICCKTPPKPH ILKTVYPGGR GLKLEVWNNS RPIRLEEILE
YNEKTPGYMG ASWVDSASYI WLMEQDTFVA RFSGFLVAPD SDVYRFYIKG DDRYAIYFSQ
TGLPEDKVRI AYHSANANSY FSSPTQRSDD IHLQKGKEYY IEILLQEYRL SAFVDVGLYQ
YRNVYTEQQT GDAVNEEQVI KSQSTILQEV QVITLENWET TNAINEVQKI KVTSPCVEAN
SCSLYQYRLI YNMEKTVFLP ADASEFILQS ALNDLWSIKP DTVQVIRTQN PQSYVYMVTF
ISTRGDFDLL GYEVVEGNNV TLDITEQTKG KPNLETFTLN WDGIASKPLT LWSSEAEFQG
AVEEMVSTKC PPQIANFEEG FVVKYFRDYE TDFNLEHINR GQKTAETDAY CGRYSLKNPA
VLFDSADVKP NRRPYGDILL FPYNQLCLAY KGFLANYIGL KFQYQDNSKI TRSTDTQFTY
NFAYGNNWTY TCIDLLDLVR TKYTGTNVSL QRISLHKASE SQSFYVDVVY IGHTSTISTL
DEMPKRRLPA LANKGIFLEH FQVNQTKTNG PTMTNQYSVT MTSYNCSYNI PMMAVSFGQI
ITHETENEFV YRGNNWPGES KIHIQRIQAA SPPLSGSFDI QAYGHILKGL PAAVSAADLQ
FALQSLEGMG RISVTREGTC AGYAWNIKWR STCGKQNLLQ INDSNIIGEK ANMTVTRIKE
GGLFRQHVLG DLLRTPSQQP QVEVYVNGIP AKCSGDCGFT WDSNITPLVL AISPSQGSYE
EGTILTIVGS GFSPSSAVTV SVGPVGCSLL SVDEKELKCQ ILNGSAGHAP VAVSMADVGL
AQNVGGEEFY FVYQSQISHI WPDSGSIAGG TLLTLSGFGF NENSKVLVGN ETCNVIEGDL
NRITCRTPKK TEGTVDISVT TNGFQATARD AFSYNCLQTP IITDFSPKVR TILGEVNLTI
KGYNFGNELT QNMAVYVGGK TCQILHWNFT DIRCLLPKLS PGKHDIYVEV RNWGFASTRD
KLNSSIQYVL EVTSMFPQRG SLFGGTEITI RGFGFSTIPA ENTVLLGSIP CNVTSSSENV
IKCILHSTGN IFRITNNGKD SVHGLGYAWS PPVLNVSVGD TVAWHWQTHP FLRGIGYRIF
SVSSPGSVIY DGKGFTSGRQ KSTSGSFSYQ FTSPGIHYYS SGYVDEAHSI FLQGVINVLP
AETRHIPLHL FVGRSEATYA YGGPENLHLG SSVAGCLATE PLCSLNNTRV KNSKRLLFEV
SSCFSPSISN ITPSTGTVNE LITIIGHGFS NLPWANKVTI GSYPCVVEES SEDSITCHID
PQNSMDVGIR ETVTLTVYNL GTAINTLSNE FDRRFVLLPN IDLVLPNAGS TTGMTSVTIK
GSGFAVSSAG VKVLMGHFPC KVLSVNYTAI ECETSPAAQQ LVDVDLLIHG VPAQCQGNCT
FSYLESITPY ITGVFPNSVI GSVKVLIEGE GLGTVLEDIA VFIGNQQFRA IEVNENNITA
LVTPLPVGHH SVSVVVGSKG LALGNLTVSS PPVASLSPTS GSIGGGTTLV ITGNGFYPGN
TTVTIGDEPC QIISINPNEV YCRTPAGTTG MVDVKIFVNT IAYPPLLFTY ALEDTPFLRG
IIPSRGPPGT EIEITGSNFG FEILEISVMI NNIQCNVTMA NDSVVQCIVG DHAGGTFPVM
MHHKTKGSAM STVVFEYPLN IQNINPSQGS FGGGQTMTVT GTGFNPQNSI ILVCGSECAI
DRLRSDYTTL LCEIPSNNGT GAEQACEVSV VNGKDLSQSM TPFTYAVSLT PLITAVSPKR
GSTAGGTRLT VVGSGFSENM EDVHITIAEA KCDVEYSNKT HIICMTDAHT LSGWAPVCVH
IRGVGMAKLD NADFLYVDAW SSNFSWGGKS PPEEGSLVVI TKGQTILLDQ STPILKMLLI
QGGTLIFDEA DIELQAENIL ITDGGVLQIG TETSPFQHKA VITLHGHLRS PELPVYGAKT
LAVREGILDL HGVPVPVTWT RLAHTAKAGE RILILQEAVT WKPGDNIVIA STGHRHSQGE
NEKMTIASVS ADGINITLSN PLNYTHLGIT VTLPDGTLFE ARAEVGILTR NILIRGSDNV
EWNNKIPACP DGFDTGEFAT QTCLQGKFGE EIGSDQFGGC VMFHAPVPGA NMVTGRIEYV
EVFHAGQAFR LGRYPIHWHL LGDLQFKSYV RGCAIHQAYN RAVTIHNTHH LLVERNIIYD
IKGGAFFIED GIEHGNILQY NLAVFVQQST SLLNDDVTPA AFWVTNPNNT IRHNAVAGGT
HFGFWYRMNN HPDGPSYDRN ICQKRVPLGE FFNNTVHSQG WFGMWIFEEY FPMQTGSCTS
TVPAPAIFNS LTTWNCQKGA EWVNGGALQF HNFVMVNNYE AGIETKRILA PYVGGWGETN
GAVIKNAKIV GHLDELGMGS AFCTAKGLVL PFSEGLTVSS VHFMNFDRPN CVALGVTSIS
GVCNDRCGGW SAKFVDVQYS HTPNKAGFRW EHEMVMIDVD GSLTGHKGHT VIPHSSLLDP
SHCTQEAEWS IGFPGSVCDA SVSFHRLAFN QPSPVSLLEK DVVLSDSFGT SIIPFQKKRL
THMSGWMALI PNANHINWYF KGVDHITNIS YTSTFYGFKE EDYVIISHNF TQNPDMFNII
DMRNGSSNPL NWNTSKNGDW HLEANTSTLY YLVSGRNDLH QSQLISGNLD PDVKDVVINF
QAYCCILQDC FPVHPPSRKP IPKKRPATYN LWSNDSFWQS SRENNYTVPH PGANVIIPEG
TWIVADIDMP SMERLIIWGV LELEDKYNVG AAESSYREVV LNATYISLQG GRLIGGWEDN
PFKGDLKIVL RGNHTTQDWA LPEGPNQGAK VLGVFGELDL HGIPHSIYKT KLSETAFAGS
KVLSLMDAVD WQEGEEIVIT TTSYDFHQTE TRSIVKILHD HKILILNDSL SYTHFAEKYH
VPGTGESYTL AADVGILSRN IKIVGEDYPG WSEDSFGARV LVGSFTENMM TFKGNARISN
VEFYHSGQEG FRDSTDPRYA VTFLNLGQIQ EHGSSYIRGC AFHHGFSPAI GVFGTDGLDI
DDNIIHFTVG EGIRIWGNAN RVRGNLIALS VWPGTYQNRK DLSSTLWHAA IEINRGTNTV
LQNNVVAGFG RAGYRIDGEP CPGQFNPVEK WFDNEAHGGL YGIYMNQDGL PGCSLIQGFT
IWTCWDYGIY FQTTESVHIY NVTLVDNGMA IFPMIYMPAA ISHKISSKNV QIKSSLIVGS
SPGFNCSDVL TNDDPNIELT AAHRSPRSPS GGRSGICWPT FASAHNMAPR KPHAGIMSYN
AISGLLDISG STFVGFKNVC SGETNVIFIT NPLNEDLQHP IHVKNIKLVD TTEQSKIFIH
RPDISKVNPS DCVDMVCDAK RKSFLRDIDG SFLGNAGSVI PQAEYEWDGN SQVGIGDYRI
PKAMLTFLNG SRIPVTEKAP HKGIIRDSTC KYLPEWQSYQ CFGMEYAMMV IESLDPDTET
RRLSPVAIMG NGYVDLINGP QDHGWCAGYT CQRRLSLFHS IVALNKSYEV YFTGTSPQNL
RLMLLNVDHN KAVLVGIFFS TLQRLDVYVN NLLVCPKTTI WNAQQKHCEL NNHLYKDQFL
PNLDSTVLGE NYFDGTYQML YLLVKGTIPV EIHTATVIFV SFQLSVATED DFYTSHNLVK
NLALFLKIPS DKIRISKIRG KSLRRKRSMG FIIEIEIGDP PIQFISNGTT GQMQLSELQE
IAGSLGQAVI LGNISSILGF NISSMSITNP LPSPSDSGWI KVTAQPVERS AFPVHHVAFV
SSLLVITQPV AAQPGQPFPQ QPSVKATDSD GNCVSVGITA LTLRAILKDS NNNQVNGLSG
NTTIPFSSCW ANYTDLTPLR TGKNYKIEFI LDNVVGVESR TFSLLAESVS SSGSSSSSNS
KASTVGTYAQ IMTVVISCLV GRMWLLEIFM AAVSTLNITL RSY
