ID   PKHM3_XENLA             Reviewed;         748 AA.
AC   Q08AW4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Pleckstrin homology domain-containing family M member 3;
DE            Short=PH domain-containing family M member 3;
GN   Name=plekhm3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role during muscle differentiation.
CC       {ECO:0000250|UniProtKB:Q8BM47}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BM47}. Golgi
CC       apparatus {ECO:0000250|UniProtKB:Q8BM47}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q8BM47}.
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DR   EMBL; BC124982; AAI24983.1; -; mRNA.
DR   RefSeq; NP_001121317.1; NM_001127845.1.
DR   RefSeq; XP_018089434.1; XM_018233945.1.
DR   RefSeq; XP_018089435.1; XM_018233946.1.
DR   AlphaFoldDB; Q08AW4; -.
DR   SMR; Q08AW4; -.
DR   GeneID; 100158401; -.
DR   KEGG; xla:100158401; -.
DR   CTD; 100158401; -.
DR   Xenbase; XB-GENE-5825077; plekhm3.L.
DR   OMA; CELCHNG; -.
DR   OrthoDB; 177737at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100158401; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045445; P:myoblast differentiation; ISS:UniProtKB.
DR   CDD; cd14674; PH_PLEKHM3_1; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037812; PLEKHM3_PH_1.
DR   InterPro; IPR025258; Zf-RING_9.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF13901; zf-RING_9; 1.
DR   SMART; SM01175; DUF4206; 1.
DR   SMART; SM00233; PH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Golgi apparatus; Membrane; Metal-binding;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..748
FT                   /note="Pleckstrin homology domain-containing family M
FT                   member 3"
FT                   /id="PRO_0000326036"
FT   DOMAIN          200..297
FT                   /note="PH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          348..443
FT                   /note="PH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   ZN_FING         656..709
FT                   /note="Phorbol-ester/DAG-type"
FT   REGION          88..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  85614 MW;  AF02A6A2B9132B5C CRC64;
     MEALEVDDIS PALEVTEDFF NSFDKLENGV HQSHVFGIHQ VPEFLGNEIS NKMKEQADGQ
     NANTSQRSII WERCKSSLFD AKTMNGIHAK EQNESTKRTY SDDPLLSEKE KGTSTFNLLR
     RLDRPHSVND SLDHLEDAPK FKPGHNRSRS DVSHIDWKNI RKPAPLQRSS SQGMHCTSPF
     SEPRNKNMEA NNEVRSSFTN ILKKGFLETR ITPESFWKGC YAEISQYELH IYGSDYSGNH
     NATDTYHLSH IESITITGSH ETKLVNVIMT DDRYLQLKAD SAWEAIDWGQ KLWEAICALN
     LVPNYRSIHQ DILKKQNNFS DGIRGCMENN VNKLTPSAMN ISNGNQKNII KTGTLYRLTI
     QSNWKAFTFV LSNSHFAAYQ PSCLDEDPLL SYNIDACIAV QMDMLDGYDS CFQVIFPQDV
     LRLRTETRQR AQEWMDAIIS AANSARKSDQ SLLVPLRKKS KENQSVKDLQ RSKRQSVTTS
     FLSLLTSLAL ERGLTAQSFK CAGCQRPIGL SNEKAKVCSY SGWYYCSTCH VDDGFIIPAR
     LIHNWDTSKH KVSKQAKEFL EYVYEEPLID VHQENPLLYR HVDALAHVVR LRQQLKSLRA
     YLFSCRAVVA EDLRRRIFPR EYLFQQIHLY SLSDLQQVVE GKLAPFLLKI IKFATSHVYS
     CSLCSQKGFI CEICNNGEIL YPFEENSTSR CENCGAVFHS DCKVRTVPCP KCVRKELQKK
     QKSFWQQLDM DGSLDEACSM FELSYQST