ID   PKHO1_CHICK             Reviewed;         423 AA.
AC   Q5F3C8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Pleckstrin homology domain-containing family O member 1;
DE            Short=PH domain-containing family O member 1;
GN   Name=PLEKHO1; ORFNames=RCJMB04_21c20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Plays a role in the regulation of the actin cytoskeleton
CC       through its interactions with actin capping protein (CP).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- PTM: C-terminal fragments could be released during apoptosis via
CC       caspase-3-dependent cleavage. {ECO:0000250}.
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DR   EMBL; AJ851722; CAH65356.1; -; mRNA.
DR   RefSeq; NP_001026527.1; NM_001031356.1.
DR   AlphaFoldDB; Q5F3C8; -.
DR   STRING; 9031.ENSGALP00000043014; -.
DR   PaxDb; Q5F3C8; -.
DR   GeneID; 426108; -.
DR   KEGG; gga:426108; -.
DR   CTD; 51177; -.
DR   VEuPathDB; HostDB:geneid_426108; -.
DR   eggNOG; ENOG502QSPU; Eukaryota.
DR   InParanoid; Q5F3C8; -.
DR   OrthoDB; 929437at2759; -.
DR   PhylomeDB; Q5F3C8; -.
DR   PRO; PR:Q5F3C8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0036195; C:muscle cell projection membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032587; C:ruffle membrane; IBA:GO_Central.
DR   GO; GO:1901739; P:regulation of myoblast fusion; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR028452; CKIP-1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR043448; PKHO1/2.
DR   PANTHER; PTHR15871; PTHR15871; 1.
DR   PANTHER; PTHR15871:SF1; PTHR15871:SF1; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..423
FT                   /note="Pleckstrin homology domain-containing family O
FT                   member 1"
FT                   /id="PRO_0000310426"
FT   DOMAIN          20..131
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  48152 MW;  505B2DB9E8CE79A2 CRC64;
     MEKNNSAKRG QQDGNQQSAQ PEKVGWVRKF CGKGIFREIW KNRYVVLKGD QLYISEKEVK
     DEKNVQEAFD LSDYEKCEEL RKSKSRSKKN HSKFTLAHSR QPGNMAPNLI FLAVSPEEKE
     SWINALNSAI TRAKNRILDE VTVEEDSYLA HPTRDRAKIQ HSRRPPTRGH LMAVASTSTS
     DGMLTLDLIQ EEDASPEEHS TCEESFRVDL DKSVAQLAAG RRRSDSENVK LSEKGRSGTL
     PRHEVTSWDK PTQRKDSLDK GTVYTPQVPK KLSHSEKNKC ASMEEILSRR DSAHRAVLRR
     GLEAHCTAAE PEQLSRLQEL VALKLEKTQE LLTEVKGYGE GKRKVKDCAT STTTSSSSSS
     SRSDCERILQ ESERLLGEAS STWSQARRVL QEVRELRDLY RQIELQQVDC NPKQSSQYRK
     SMM