ID   PKHO2_BOVIN             Reviewed;         499 AA.
AC   Q32LQ1; Q0V8J7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Pleckstrin homology domain-containing family O member 2;
DE            Short=PH domain-containing family O member 2;
DE   AltName: Full=Pleckstrin homology domain-containing family Q member 1;
DE            Short=PH domain-containing family Q member 1;
GN   Name=PLEKHO2; Synonyms=PLEKHQ1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-499.
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
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DR   EMBL; BC109475; AAI09476.1; -; mRNA.
DR   EMBL; BT026221; ABG67060.1; -; mRNA.
DR   RefSeq; NP_001069751.1; NM_001076283.2.
DR   AlphaFoldDB; Q32LQ1; -.
DR   SMR; Q32LQ1; -.
DR   STRING; 9913.ENSBTAP00000011069; -.
DR   PaxDb; Q32LQ1; -.
DR   PRIDE; Q32LQ1; -.
DR   GeneID; 613696; -.
DR   KEGG; bta:613696; -.
DR   CTD; 80301; -.
DR   eggNOG; ENOG502QVFF; Eukaryota.
DR   InParanoid; Q32LQ1; -.
DR   OrthoDB; 827145at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0071888; P:macrophage apoptotic process; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR043448; PKHO1/2.
DR   PANTHER; PTHR15871; PTHR15871; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..499
FT                   /note="Pleckstrin homology domain-containing family O
FT                   member 2"
FT                   /id="PRO_0000309482"
FT   DOMAIN          18..119
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          416..492
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        198..212
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..419
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TD55"
FT   MOD_RES         237
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K124"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K124"
FT   MOD_RES         273
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TD55"
FT   MOD_RES         298
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K124"
FT   MOD_RES         311
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TD55"
FT   MOD_RES         399
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TD55"
FT   CONFLICT        243
FT                   /note="G -> E (in Ref. 2; ABG67060)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   499 AA;  54119 MW;  F60F0EA36342BDCC CRC64;
     MEEEGVKEGG QRPRSAQTAD KAGWIKKSSG GFLGLWKDRY LLLCQAQLLV YENEDEQKCV
     ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ APSGEEKESW IKALNEGINR
     GKNKAFDEVK VDKSCVLEHV TRDRVRRDQR RRPPTRVHLK EVANAASDGL SRLDLDVPDS
     GPPVLAPSND VDAAQPRETP RPPMPPAKPS PAPETSSAGD RMETPVGQSA PAPVPASSEA
     HPGSQEDLET PVVEDSDSEQ PPNRILPDKL KVSWENPSPE EAPDSESAEP PQVPGAETSE
     AGPREGGKPP TPPPKILSEK LKASMSGMEA SGPAQSPGAS EASAPGPAEV SVNGVDDSPE
     PLQSSQAAGP PGTPPKAATT STTLPPWDLQ PQLHPRCSSL GDLLGEGPRR RRQPGEQLHR
     AQLEVKVASE KTEKLLNKVL GGESASVNAE TLLSQAVEQL RQATQVLQEI RDLEEMNREA
     PGLREKRREL VTLYRRSVP