PKHS1_MOUSE
ID PKHS1_MOUSE Reviewed; 474 AA.
AC Q8BW88; E9QMW0; Q5EAT4; Q8BZ18; Q8R5A9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Pleckstrin homology domain-containing family S member 1 {ECO:0000305};
DE Short=PH domain-containing family S member 1;
GN Name=Plekhs1 {ECO:0000312|MGI:MGI:2443041};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Oviduct, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 195-474 (ISOFORM 4).
RC STRAIN=Czech II, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8BW88-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BW88-2; Sequence=VSP_031732, VSP_031735, VSP_031736;
CC Name=3;
CC IsoId=Q8BW88-3; Sequence=VSP_031732, VSP_031733;
CC Name=4;
CC IsoId=Q8BW88-4; Sequence=VSP_031734;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29634.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK036908; BAC29634.1; ALT_INIT; mRNA.
DR EMBL; AK053921; BAC35594.1; -; mRNA.
DR EMBL; AC166746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC023098; AAH23098.1; -; mRNA.
DR EMBL; BC090250; AAH90250.1; -; mRNA.
DR CCDS; CCDS29916.1; -. [Q8BW88-1]
DR CCDS; CCDS57148.1; -. [Q8BW88-3]
DR RefSeq; NP_001157735.1; NM_001164263.1. [Q8BW88-3]
DR RefSeq; NP_766229.2; NM_172641.3. [Q8BW88-1]
DR RefSeq; XP_006527081.1; XM_006527018.2. [Q8BW88-1]
DR AlphaFoldDB; Q8BW88; -.
DR SMR; Q8BW88; -.
DR STRING; 10090.ENSMUSP00000035440; -.
DR iPTMnet; Q8BW88; -.
DR PhosphoSitePlus; Q8BW88; -.
DR PaxDb; Q8BW88; -.
DR PRIDE; Q8BW88; -.
DR ProteomicsDB; 289513; -. [Q8BW88-1]
DR ProteomicsDB; 289514; -. [Q8BW88-2]
DR ProteomicsDB; 289515; -. [Q8BW88-3]
DR ProteomicsDB; 289516; -. [Q8BW88-4]
DR Antibodypedia; 31887; 68 antibodies from 12 providers.
DR DNASU; 226245; -.
DR Ensembl; ENSMUST00000039666; ENSMUSP00000035440; ENSMUSG00000035818. [Q8BW88-1]
DR Ensembl; ENSMUST00000178590; ENSMUSP00000136674; ENSMUSG00000035818. [Q8BW88-3]
DR GeneID; 226245; -.
DR KEGG; mmu:226245; -.
DR UCSC; uc008hyy.2; mouse. [Q8BW88-1]
DR UCSC; uc008hyz.2; mouse. [Q8BW88-3]
DR CTD; 79949; -.
DR MGI; MGI:2443041; Plekhs1.
DR VEuPathDB; HostDB:ENSMUSG00000035818; -.
DR eggNOG; ENOG502RDEC; Eukaryota.
DR GeneTree; ENSGT00390000006729; -.
DR HOGENOM; CLU_049125_1_0_1; -.
DR InParanoid; Q8BW88; -.
DR OMA; RICVARW; -.
DR OrthoDB; 924973at2759; -.
DR TreeFam; TF334193; -.
DR BioGRID-ORCS; 226245; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BW88; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BW88; protein.
DR Bgee; ENSMUSG00000035818; Expressed in prostate gland ventral lobe and 37 other tissues.
DR ExpressionAtlas; Q8BW88; baseline and differential.
DR Genevisible; Q8BW88; MM.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042986; PLEKHS1.
DR PANTHER; PTHR47014; PTHR47014; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..474
FT /note="Pleckstrin homology domain-containing family S
FT member 1"
FT /id="PRO_0000320676"
FT DOMAIN 20..135
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 232..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 76
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031732"
FT VAR_SEQ 145
FT /note="E -> EQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031733"
FT VAR_SEQ 287
FT /note="Q -> QTSPE (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031734"
FT VAR_SEQ 336
FT /note="N -> K (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031735"
FT VAR_SEQ 337..474
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031736"
FT CONFLICT 280
FT /note="N -> D (in Ref. 3; AAH23098)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="D -> G (in Ref. 3; AAH23098)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="E -> G (in Ref. 1; BAC35594)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 53077 MW; 5936196F40EA6FB7 CRC64;
MEARPPKGPG KQFTFDYENE VHKRDYFIKS PPPQLFFSGT SWKKRLFILS QSRGTGLSLS
YYKDHQHRGS IEIDGSSTVE VGINCQEKMQ SVQKMFKCHP DEVMSIRTAN RDYFLIGHDR
EKIKDWVSFM TPYCQGVKAT HQRAEEKLSL GDRRPVSDPS PFLGLCSIPE GIRLASPRAS
LPEHLIQKSL QRFRQAHLHQ DHDFHSEPTQ DTEEEYYLTP RSLEACLELE NIAGPNDSGD
SIESNSPDQG FKRAESNYVS MRSLRTCLLK ESTSASADDN DGQAEFQTES ELGPPHQDSG
TGSDPCLSPP NSKAQTTDDQ KGSASLTVVK LSILLNNIPD ESQVETLNVF LSPRDAIDYL
ALVEAAGQIC VARWEGPPRL GCLFYHGDHI LAVNDLKPQS LEEVSLFLTR CIQKEKVKLS
IGRIPNSEKL HASPCACSLR HQLAESVQRD LPELERTPKR SPAIKKSQKE AAGE
