ID   PKIA_DICDI              Reviewed;         127 AA.
AC   Q23921; Q54HI7; Q9NL64;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Protein pkiA;
DE   AltName: Full=Protein DD-1;
GN   Name=pkiA; ORFNames=DDB_G0289391;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX2;
RX   PubMed=10795321; DOI=10.1093/pcp/41.2.239;
RA   Yoshida M., Sendai Y., Sakuragi N., Hotta Y.;
RT   "Analysis of a mod B mutant in Dictyostelium discoideum using mRNA
RT   differential display.";
RL   Plant Cell Physiol. 41:239-243(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AX4;
RX   PubMed=8643615; DOI=10.1073/pnas.93.11.5562;
RA   Kuspa A., Loomis W.F.;
RT   "Ordered yeast artificial chromosome clones representing the Dictyostelium
RT   discoideum genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16512674; DOI=10.1021/pr050350q;
RA   Reinders Y., Schulz I., Graef R., Sickmann A.;
RT   "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT   by comparative proteomic approaches.";
RL   J. Proteome Res. 5:589-598(2006).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB03669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB029922; BAA89663.1; -; mRNA.
DR   EMBL; U61986; AAB03669.1; ALT_INIT; mRNA.
DR   EMBL; AAFI02000140; EAL62723.1; -; Genomic_DNA.
DR   RefSeq; XP_636246.1; XM_631154.1.
DR   AlphaFoldDB; Q23921; -.
DR   SMR; Q23921; -.
DR   IntAct; Q23921; 1.
DR   STRING; 44689.DDB0216234; -.
DR   PaxDb; Q23921; -.
DR   EnsemblProtists; EAL62723; EAL62723; DDB_G0289391.
DR   GeneID; 8627136; -.
DR   KEGG; ddi:DDB_G0289391; -.
DR   dictyBase; DDB_G0289391; pkiA.
DR   eggNOG; KOG3275; Eukaryota.
DR   HOGENOM; CLU_056776_8_1_1; -.
DR   InParanoid; Q23921; -.
DR   OMA; YHLHAHL; -.
DR   PhylomeDB; Q23921; -.
DR   PRO; PR:Q23921; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR   Gene3D; 3.30.428.10; -; 1.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR23089; PTHR23089; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..127
FT                   /note="Protein pkiA"
FT                   /id="PRO_0000109805"
FT   DOMAIN          16..127
FT                   /note="HIT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00464"
FT   CONFLICT        117..127
FT                   /note="LGGRQMNWPPG -> PWW (in Ref. 2; AAB03669)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   127 AA;  14055 MW;  845C43FD16759C07 CRC64;
     MSESVGNIRI DPRDTIFAKI ISGAIPSKKF YDDEYCIAIE DINPQAPVHL LVIPKLAVGG
     LSDVANVDLE KYKESMGHIM SKIHHIASLK GADSYRLVIN EGVLGQQSVR WLHIHILGGR
     QMNWPPG