ID   A6_VARV                 Reviewed;         372 AA.
AC   P0DSR2; P33833;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 11.
DE   RecName: Full=Protein A6;
GN   ORFNames=A6L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Shchelkunov S.N., Totmenin A.V., Safronov P.F., Resenchuk S.M.,
RA   Blinov V.M., Sandakhchiev L.S.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in immature virion (IV) to mature
CC       virion (MV) transition. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22579; AAA60858.1; -; Genomic_DNA.
DR   EMBL; X76265; CAA53848.1; -; Genomic_DNA.
DR   PIR; D72164; D72164.
DR   PIR; T28548; T28548.
DR   RefSeq; NP_042154.1; NC_001611.1.
DR   SMR; P0DSR2; -.
DR   GeneID; 1486536; -.
DR   KEGG; vg:1486536; -.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR007008; Poxvirus_A6.
DR   Pfam; PF04924; Pox_A6; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..372
FT                   /note="Protein A6"
FT                   /id="PRO_0000448150"
SQ   SEQUENCE   372 AA;  43149 MW;  9751173CE363452D CRC64;
     MDKLRVLYDE FVTISKDNLE RETGLSASDV DMDFDLNIFM TLVPVLEKKV CVITPTIEDD
     KIVTMMKYCS YQSFSFWFLK SGAVVKSVYN KLDDAEKEKF VATFKDMLLN VQTLISLNSM
     YTRLRQDTED IVSDSKKIME IVSHLRASTT ENAAYQVLQQ NNSFIISTLN KILSDENYLL
     KIIAVFDSKL ISEKETLNEY KQLYTISSES LVYGIRCVSN LDISSVQLSN NKYVLFVKKM
     LPKIILFQNN DINAQQFANV ISKIYTLIYR QLTSNVDVGC LLTDTIESTK TKISVEKFKQ
     TGINNVQSLI KFISDNKKEY KTIISEEYLS KEDRIITILQ NIVNEHDIKY DNNLLNMRDL
     IVTFRERYSY KF