PKNX1_BOVIN
ID PKNX1_BOVIN Reviewed; 436 AA.
AC Q2HJ84;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Homeobox protein PKNOX1;
DE AltName: Full=PBX/knotted homeobox 1;
GN Name=PKNOX1 {ECO:0000250|UniProtKB:P55347};
GN Synonyms=PREP1 {ECO:0000250|UniProtKB:P55347};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates transcription in the presence of PBX1A and HOXA1.
CC {ECO:0000250|UniProtKB:O70477}.
CC -!- SUBUNIT: Interacts with MN1. {ECO:0000250|UniProtKB:P55347}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
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DR EMBL; BC113256; AAI13257.1; -; mRNA.
DR RefSeq; NP_001039815.1; NM_001046350.1.
DR AlphaFoldDB; Q2HJ84; -.
DR SMR; Q2HJ84; -.
DR STRING; 9913.ENSBTAP00000018809; -.
DR PaxDb; Q2HJ84; -.
DR PRIDE; Q2HJ84; -.
DR Ensembl; ENSBTAT00000018809; ENSBTAP00000018809; ENSBTAG00000014153.
DR GeneID; 533382; -.
DR KEGG; bta:533382; -.
DR CTD; 5316; -.
DR VEuPathDB; HostDB:ENSBTAG00000014153; -.
DR VGNC; VGNC:32948; PKNOX1.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000159505; -.
DR HOGENOM; CLU_023139_0_2_1; -.
DR InParanoid; Q2HJ84; -.
DR OMA; QHVTMPD; -.
DR OrthoDB; 1221551at2759; -.
DR TreeFam; TF318093; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000014153; Expressed in spermatid and 105 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..436
FT /note="Homeobox protein PKNOX1"
FT /id="PRO_0000249878"
FT DOMAIN 80..163
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000255"
FT DNA_BIND 259..321
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 24..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70477"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P55347"
SQ SEQUENCE 436 AA; 47204 MW; 0D1C0BC838786EB1 CRC64;
MMATQTLSID SYPDGQQMQV VTELKTEQDP NCSEPDVEGV SPPPVGSQTP MDADKQAIYR
HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK
AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI
TGTLSPQGIV VPASALQQGN VTMATVAGGT VYQPVTVVTP QGQVVTQALS PGTIRIQNSQ
LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN
LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI ASGAAQPAAS
ELTVSEGAVV TITAPVSMNV DSLQSLSSDG ATLAVQQVMM AEQSEDDSVD STGDGGAALA
PGHLGGLVLE NSDSLQ