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PKNX2_MOUSE
ID   PKNX2_MOUSE             Reviewed;         474 AA.
AC   Q8BG99; Q8R4B0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Homeobox protein PKNOX2;
DE   AltName: Full=Homeobox protein PREP-2;
DE   AltName: Full=PBX/knotted homeobox 2;
GN   Name=Pknox2; Synonyms=Prep2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=FVB/N;
RX   PubMed=12412021; DOI=10.1002/dvdy.10167;
RA   Haller K., Rambaldi I., Kovacs E.N., Daniels E., Featherstone M.;
RT   "Prep2: cloning and expression of a new prep family member.";
RL   Dev. Dyn. 225:358-364(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yamagishi A., Shinya M., Takeda H., Kuroiwa A.;
RT   "Prep2, a novel Pbx partner expressed in the distinctive domains during
RT   vertebrate embryogenesis.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM18702.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF487460; AAM18702.1; ALT_INIT; mRNA.
DR   EMBL; AB086817; BAC20215.1; -; mRNA.
DR   EMBL; AK082952; BAC38705.1; -; mRNA.
DR   EMBL; BC050865; AAH50865.2; -; mRNA.
DR   CCDS; CCDS22974.1; -.
DR   RefSeq; NP_001025009.1; NM_001029838.2.
DR   RefSeq; NP_683752.2; NM_148950.3.
DR   RefSeq; XP_006510187.1; XM_006510124.3.
DR   RefSeq; XP_006510188.1; XM_006510125.3.
DR   RefSeq; XP_006510189.1; XM_006510126.3.
DR   RefSeq; XP_006510190.1; XM_006510127.3.
DR   RefSeq; XP_017168744.1; XM_017313255.1.
DR   AlphaFoldDB; Q8BG99; -.
DR   SMR; Q8BG99; -.
DR   BioGRID; 228942; 6.
DR   IntAct; Q8BG99; 6.
DR   STRING; 10090.ENSMUSP00000035806; -.
DR   iPTMnet; Q8BG99; -.
DR   PhosphoSitePlus; Q8BG99; -.
DR   MaxQB; Q8BG99; -.
DR   PaxDb; Q8BG99; -.
DR   PeptideAtlas; Q8BG99; -.
DR   PRIDE; Q8BG99; -.
DR   ProteomicsDB; 289753; -.
DR   Antibodypedia; 9279; 201 antibodies from 28 providers.
DR   DNASU; 208076; -.
DR   Ensembl; ENSMUST00000039674; ENSMUSP00000035806; ENSMUSG00000035934.
DR   Ensembl; ENSMUST00000080754; ENSMUSP00000079578; ENSMUSG00000035934.
DR   Ensembl; ENSMUST00000177218; ENSMUSP00000135581; ENSMUSG00000035934.
DR   GeneID; 208076; -.
DR   KEGG; mmu:208076; -.
DR   UCSC; uc009oue.3; mouse.
DR   CTD; 63876; -.
DR   MGI; MGI:2445415; Pknox2.
DR   VEuPathDB; HostDB:ENSMUSG00000035934; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   GeneTree; ENSGT00940000158793; -.
DR   HOGENOM; CLU_023139_0_2_1; -.
DR   InParanoid; Q8BG99; -.
DR   OMA; CAPVNDM; -.
DR   OrthoDB; 1221551at2759; -.
DR   PhylomeDB; Q8BG99; -.
DR   TreeFam; TF318093; -.
DR   BioGRID-ORCS; 208076; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Pknox2; mouse.
DR   PRO; PR:Q8BG99; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BG99; protein.
DR   Bgee; ENSMUSG00000035934; Expressed in floor plate of midbrain and 183 other tissues.
DR   ExpressionAtlas; Q8BG99; baseline and differential.
DR   Genevisible; Q8BG99; MM.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0045171; C:intercellular bridge; ISO:MGI.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0051015; F:actin filament binding; IDA:MGI.
DR   GO; GO:0003785; F:actin monomer binding; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IGI:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..474
FT                   /note="Homeobox protein PKNOX2"
FT                   /id="PRO_0000249880"
FT   DOMAIN          96..179
FT                   /note="MEIS N-terminal"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        291..350
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..458
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  52331 MW;  B2B160A7D13E7579 CRC64;
     MMQHASPAPA LTMMATQNVP PPPYQDSPQM TATAQPPSKA QAVHISAPSA TASTPVPSAP
     IDPQAQLEAD KRAVYRHPLF PLLTLLFEKC EQATQGSECI TSASFDVDIE NFVHQQEQEH
     KPFFSDDPEL DNLMVKAIQV LRIHLLELEK VNELCKDFCN RYITCLKTKM HSDNLLRNDL
     GGPYSPNQPS INLHSQDLLQ NSPNSMSGVS NNPQGIVVPA SALQQGNIAM TTVNSQVVSG
     GALYQPVTMV TSQGQVVTQA IPQGAIQIQN TQVNLDLTSL LDNEDKKSKN KRGVLPKHAT
     NIMRSWLFQH LMHPYPTEDE KRQIAAQTNL TLLQVNNWFI NARRRILQPM LDASNPDPAP
     KAKKIKSQHR PTQRFWPNSI AAGVLQQQGG TPGTNPDGSI NLDNLQSLSS DNATMAMQQA
     MMAAHDDSLD GTEEEDEDDM EEEEEEEEEL EEEADELQTT NVSDLGLEHS DSLE
 
 
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