ID   PKNX2_PONAB             Reviewed;         472 AA.
AC   Q5R6L1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Homeobox protein PKNOX2;
DE   AltName: Full=PBX/knotted homeobox 2;
GN   Name=PKNOX2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
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DR   EMBL; CR860477; CAH92599.1; -; mRNA.
DR   RefSeq; NP_001127567.1; NM_001134095.1.
DR   AlphaFoldDB; Q5R6L1; -.
DR   SMR; Q5R6L1; -.
DR   STRING; 9601.ENSPPYP00000004607; -.
DR   GeneID; 100174645; -.
DR   KEGG; pon:100174645; -.
DR   CTD; 63876; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   InParanoid; Q5R6L1; -.
DR   OrthoDB; 1221551at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Homeobox protein PKNOX2"
FT                   /id="PRO_0000249879"
FT   DOMAIN          96..179
FT                   /note="MEIS N-terminal"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        291..350
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..456
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   472 AA;  52041 MW;  C265116370D4E2B0 CRC64;
     MMQHASPAPA LTMMATQNVP PPPYQDSPQM TATTQPPSKA QAVHISAPSA AASTPVPSAP
     IDPQAQLEAD KRAVYRHPLF PLLTLLFEKC EQATQGSECI TSASFDVDIE NFVHQQEQEH
     KPFFSDDPEL DNLMVKAIQV LRIHLLELEK VNELCKDFCN RYITCLKTKM HSDNLLRNDL
     GGPYSPNQPS INLHSQDLLQ NSPNSMSGVS NNPQGIVVPA SALQQGNIAM TTVNSQVVSG
     GALYQPVTMV TSQGQVVTQA IPQGAIQIQN TQVNLDLTSL LDNEDKKSKN KRGVLPKHAT
     NIMRSWLFQH LMHPYPTEDE KRQIAAQTNL TLLQVNNWFV NARRRILQPM LDASNPDPAP
     KAKKIKSQHR PTQRFWPNSI AAGVLQQQGG APGTNPDGSI NLDNLQSLSS DNATMAMQQA
     MMAAHDDSLD GTEEEDEDEM EEEEEEELEE EVDELQTTNV SDLGLEHSDS LV