ID   PKP1_BOVIN              Reviewed;         727 AA.
AC   Q28161;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Plakophilin-1;
DE   AltName: Full=Band-6 protein;
DE            Short=B6P;
GN   Name=PKP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7890138; DOI=10.1046/j.1432-0436.1995.5820113.x;
RA   Heid H.W., Schmidt A., Zimbelmann R., Schaefer S., Winter-Simanowski S.,
RA   Stumpp S., Keith M., Figge U., Schnolzer M., Franke W.W.;
RT   "Cell type-specific desmosomal plaque proteins of the plakoglobin family:
RT   plakophilin 1 (band 6 protein).";
RL   Differentiation 58:113-131(1994).
CC   -!- FUNCTION: Seems to play a role in junctional plaques. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell junction, desmosome
CC       {ECO:0000250}. Note=Nuclear and associated with desmosomes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; Z37975; CAA86029.1; -; mRNA.
DR   RefSeq; NP_776570.1; NM_174145.2.
DR   AlphaFoldDB; Q28161; -.
DR   SMR; Q28161; -.
DR   STRING; 9913.ENSBTAP00000055583; -.
DR   PeptideAtlas; Q28161; -.
DR   PRIDE; Q28161; -.
DR   GeneID; 281405; -.
DR   KEGG; bta:281405; -.
DR   CTD; 5317; -.
DR   InParanoid; Q28161; -.
DR   OrthoDB; 765704at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR028432; Plakophilin-1.
DR   InterPro; IPR028435; Plakophilin/d_Catenin.
DR   PANTHER; PTHR10372; PTHR10372; 1.
DR   PANTHER; PTHR10372:SF3; PTHR10372:SF3; 1.
DR   Pfam; PF00514; Arm; 1.
DR   SMART; SM00185; ARM; 7.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   CHAIN           1..727
FT                   /note="Plakophilin-1"
FT                   /id="PRO_0000064283"
FT   REPEAT          244..275
FT                   /note="ARM 1"
FT   REPEAT          276..317
FT                   /note="ARM 2"
FT   REPEAT          318..360
FT                   /note="ARM 3"
FT   REPEAT          361..412
FT                   /note="ARM 4"
FT   REPEAT          413..443
FT                   /note="ARM 5"
FT   REPEAT          505..536
FT                   /note="ARM 6"
FT   REPEAT          537..583
FT                   /note="ARM 7"
FT   REPEAT          584..629
FT                   /note="ARM 8"
FT   REPEAT          630..693
FT                   /note="ARM 9"
FT   REGION          48..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P97350"
FT   MOD_RES         143
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P97350"
SQ   SEQUENCE   727 AA;  80180 MW;  3A27979279BCCEDF CRC64;
     MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS
     TLSHSNRGSM YDGLADSYNN YGTSSRSSFY SKFQAGSGSW GYPIYNGTLK READNRRFSS
     YSQMESWGRQ YPRGGCTAAG AGSDICFMQK IKASRSEPDL YCDPRGTLRK GTLGGKGHKT
     TQNRYSFYST CSGQKAVKKY PGRPPSCTSR QDPVCVPPTS CTKDLSFSHS RASSKICSED
     IECSGLTIPK AVQYLSSQDE KCQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP
     NQNVQQAAAG ALRNLVFRST TNKLETRRQN GIREAVSLLR RTGSTEIQKQ LTGLLWNLSS
     TDELKEELIA EALPVLADRV IIPFSGWCDG NSNLSREPVD PEVFFNATGC LRNLSSADVG
     RQTMRNYTGL IDSLMAYVQN CVAANRCDDK SVENCMCVLH NLSYRLDAEV PTRYRQLEYN
     ARNAYTDKSS TGCFSNKSDR MTNNNYDCPL PEEEPNPKGS SWLYHSDAVR TYLNLMGKSK
     KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPHI ARLLQSGNSD VVRSGASLLS
     NMSRHPALHR VMGTQVFPEV TRLLTSHTGN TSNSEDILAS ACYTVRNLMA SLPGMAKQHF
     SSSMVNNIIN LCRSSTSPKA AEAARLLLSD MWSSRELQGL LRQQGFDRSM LGTLAGANSL
     RNFTSRF